Evaluation of corpus callosum morphometry in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Fırat, Ayşegül; Tascioglu, A. Beliz; Demiryürek, Mehmet; Saygı, Serap; Oğuz, Kader K.; Tezer, F. İrsel; Hayran, M.

doi:10.1007/s00276-013-1144-y

Cited by 9 publications

(20 citation statements)

References 23 publications

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“…Therefore, it is unclear whether gender is a factor affecting the CC size in patients with TLE. The differences between the patients and control group were statistically significant for the isthmus and splenium of the CC 4. In our study, we compared the CC sizes and TBV in females and males within each group: the control group, and the TLE group.…”

Section: Discussionmentioning

confidence: 85%

“…No detailed research has been carried out to determine the size of the CC in the brain and decrease in amount of CC. In different studies, CC neuronal cortical atrophy has been observed in epilepsy patients 4,13,15. However, these studies do not clearly express whether this atrophy affects the whole brain.…”

Section: Discussionmentioning

confidence: 95%

“…Hutchinson et al24 reported no difference in the callosal volumes of children with new-onset epilepsy, and age-matched controls. Fırat et al4 and O’Dwyer et al15 found that in TLE patients, there is a constant decrease in the CC volume with an increased duration of epilepsy. A significant CC volume reduction was reported by Hermann et al22 for early-onset TLE patients as compared with late-onset patients and controls.…”

Section: Discussionmentioning

confidence: 99%

“…There are inconsistent reports concerning the volume of the CC in patients with epilepsy. Firat et al4 and Pulsipher et al16 reported that it was decreased, and O’Kusky et al17 reported that there was no difference in the CC volumes of patients with epilepsy when compared with the CC of healthy subjects. Differences in the CC volumes of individuals with epilepsy may be due to methodological differences in the studies.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown us that a slimming of the CC is seen in patients with epilepsy. The CC is the largest commissural pathway that interconnects the 2 hemispheres of the brain 4. In the literature, the CC is recognized as especially related to age, gender, brain functions, and neurologic diseases 5.…”

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confidence: 99%

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Planimetry investigation of the corpus callosum in temporal lobe epilepsy patients

Çağlar

Selen

Demir

et al. 2016

NSJ

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Objective:To evaluate the effects of temporal lobe epilepsy (TLE) on corpus callosum (CC) morphometry in patients with TLE.Methods:This retrospective study was conducted at the Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey between November 2010 and December 2013. The epileptic syndrome diagnosis was based on International League Against Epilepsy criteria, and this study was conducted on the MRIs of 25 epilepsy patients and 25 control subjects. We classified the patients according to their duration of epilepsy <10 and ≥10 years. The projection area length (PAL) of the CC was also estimated. Total brain volumes (TBV) were measured on CT images.Results:The mean values of TBV for patients with TLE and the control group were not statistically different, but the CC PAL values were statistically different. The mean CC PAL values of under and over 25 years of age in patients with TLE were statistically different. The mean values of TBV of under and over 10 years duration of TLE were small statistically, but the CC PAL values were statistically different.Conclusion:The results indicate a clear influence of TLE on the structure of the CC rather than TBV.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Planimetry investigation of the corpus callosum in temporal lobe epilepsy patients

Çağlar

Selen

Demir

et al. 2016

NSJ

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DTI-based response-driven modeling of mTLE laterality

Nazem-Zadeh

Elisevich

Air

et al. 2016

NeuroImage: Clinical

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PurposeTo develop lateralization models for distinguishing between unilateral and bilateral mesial temporal lobe epilepsy (mTLE) and determining laterality in cases of unilateral mTLE.BackgroundmTLE is the most common form of medically refractory focal epilepsy. Many mTLE patients fail to demonstrate an unambiguous unilateral ictal onset. Intracranial EEG (icEEG) monitoring can be performed to establish whether the ictal origin is unilateral or truly bilateral with independent bitemporal ictal origin. However, because of the expense and risk of intracranial electrode placement, much research has been done to determine if the need for icEEG can be obviated with noninvasive neuroimaging methods, such as diffusion tensor imaging (DTI).MethodsFractional anisotropy (FA) was used to quantify microstructural changes reflected in the diffusivity properties of the corpus callosum, cingulum, and fornix, in a retrospective cohort of 31 patients confirmed to have unilateral (n = 24) or bilateral (n = 7) mTLE. All unilateral mTLE patients underwent resection with an Engel class I outcome. Eleven were reported to have hippocampal sclerosis on pathological analysis; nine had undergone prior icEEG. The bilateral mTLE patients had undergone icEEG demonstrating independent epileptiform activity in both right and left hemispheres. Twenty-three nonepileptic subjects were included as controls.ResultsIn cases of right mTLE, FA showed significant differences from control in all callosal subregions, in both left and right superior cingulate subregions, and in forniceal crura. Comparison of right and left mTLE cases showed significant differences in FA of callosal genu, rostral body, and splenium and the right posteroinferior and superior cingulate subregions. In cases of left mTLE, FA showed significant differences from control only in the callosal isthmus. Significant differences in FA were identified when cases of right mTLE were compared with bilateral mTLE cases in the rostral and midbody callosal subregions and isthmus. Based on 11 FA measurements in the cingulate, callosal and forniceal subregions, a response-driven lateralization model successfully differentiated all cases (n = 54) into groups of unilateral right (n = 12), unilateral left (n = 12), and bilateral mTLE (n = 7), and nonepileptic control (23).ConclusionThe proposed response-driven DTI biomarker is intended to lessen diagnostic ambiguity of laterality in cases of mTLE and help optimize selection of surgical candidates. Application of this model shows promise in reducing the need for invasive icEEG in prospective cases.

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Asymmetry and Interhemispheric Connections

Clark

Boutros

Mendez

The Brain and Behavior

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Evaluation of corpus callosum morphometry in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

Cited by 9 publications

References 23 publications

Planimetry investigation of the corpus callosum in temporal lobe epilepsy patients

Planimetry investigation of the corpus callosum in temporal lobe epilepsy patients

DTI-based response-driven modeling of mTLE laterality

Asymmetry and Interhemispheric Connections

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