Evaluation of Coronary Calcium Score by Multidetector Computed Tomography in Relation to Endothelial Function and Inflammatory Markers in Asymptomatic Individuals

Ramadan, Mahmoud M.; Mahfouz, Essam M.; Gomaa, Gamal F.; El-Diasty, Tarek; Alldawi, Louie; Ikrar, Taruna; Ding, Limin; Kodama, Makoto; Aizawa, Yoshifusa

doi:10.1253/circj.72.778

Cited by 37 publications

(29 citation statements)

References 42 publications

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“…Although we did not investigate the vascular calcification markers in subjects, the impairment of NMD in PD patients seemed to imply that vascular calcification or vessel stiffness played a role in the development of ED in this study [35,[40][41][42].…”

Section: Discussionmentioning

confidence: 73%

Association of inflammation and protein-energy wasting with endothelial dysfunction in peritoneal dialysis patients

Choi

Lee

Han

et al. 2009

Nephrology Dialysis Transplantation

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Background. Cardiovascular disease is the main cause of mortality in end-stage renal disease (ESRD) patients. Recent studies have indicated that non-traditional risk factors such as endothelial dysfunction (ED), chronic inflammation and protein-energy wasting (PEW) may contribute significantly to the increased cardiovascular mortality among dialysis patients. To further ascertain this association, we carried out a cross-sectional assessment of nutritional status, inflammatory markers and endothelial dysfunction in peritoneal dialysis (PD) patients. Methods. We measured ED functionally by flow-mediated vasodilatation (FMD) using doppler ultrasonography and biochemically by soluble intercellular adhesion molecule-1 (sICAM-1) in 105 stable PD patients and 32 age-and sex-matched healthy controls. We also simultaneously measured inflammatory markers and performed a subjective global assessment (SGA) of their nutritional status using a seven-point scoring scale. Subjects were subgrouped according to their nutritional and inflammatory status. Results. In PD patients, FMD was markedly lower (9.9± 4.8% vs. 16.4±4.8%, P<0.05), and sICAM-1 was significantly higher than those in controls. The malnourished patients had significantly lower FMD (8.4±4.6% vs. 10.8±4.7%, P<0.05) and higher sICAM-1 than the nourished patients. The inflamed group had significantly lower FMD (7.1 ± 3.8 vs.11.1 ± 4.6%, P < 0.05) and higher sI-CAM-1 than the non-inflamed group. In all PD patients, lean body mass/body weight %, albumin and SGA correlated positively with FMD (r = +0.207, r = +0.224, r = +0.285, P<0.05). However, age, log high sensitivity C-reactive protein (hsCRP), log IL-6 and sICAM-1 were negatively correlated with FMD (r= −0.275, r = −0.361, r = −0.360, r = −0.271, P<0.05). A multiple regression analysis showed that log hsCRP was an independent factor affecting FMD. Endothelial function, demonstrated as FMD and sICAM-1 in the nourished PD patients without inflammation, was well preserved compared to other subgroups. Conclusion. Our data suggest that chronic inflammation and PEW are closely linked to ED in PD patients.

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Section: Discussionmentioning

confidence: 73%

Association of inflammation and protein-energy wasting with endothelial dysfunction in peritoneal dialysis patients

Choi

Lee

Han

et al. 2009

Nephrology Dialysis Transplantation

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“…Indeed, in our study the patients with CAD showed different EAT radiodensities as compared with their healthy counterparts and EAT radiodensity also correlated with CAC score, a well-validated quantitative measure of atherosclerotic burden, and a correlate of endothelial dysfunction. 33, 34 Both of the associations persisted after adjustment for conventional cardiovascular risk factors. Coronary atherosclerosis was associated with greater EAT radiodensity, which may suggest a greater ratio of hyperdense 'nonfatty' to hypodense 'fatty' components within the EAT of patients with CAD.…”

Section: Discussionmentioning

confidence: 97%

Epicardial Adipose Tissue Radiodensity Is Independently Related to Coronary Atherosclerosis - A Multidetector Computed Tomography Study -

Pracoń¹,

Kruk²,

Kępka³

et al. 2011

Circ J

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“…Liu et al [15] reported that blood pressure variability was an independent risk factor for deep CMB development and progression. Endothelium-dependent vasodilation was also reported to be impaired in patients with arterial calcification [16]. Through these presumed mechanisms, cerebral arterial calcification might contribute to the vascular injury to the brain.…”

Section: Discussionmentioning

confidence: 99%

Carotid Artery Calcification Is Associated with Deep Cerebral Microbleeds

et al. 2014

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Background/Aims: The aim of the present study was to determine the association between arterial calcification and cerebral microbleeds (CMB) relative to their distribution. Methods: We identified 834 consecutive patients with acute ischemic stroke or transient ischemic attack who underwent CT angiography and susceptibility-weighted imaging. Results: Internal carotid artery (ICA) calcification and CMB were found in 660 patients (79.1%) and 335 patients (40.2%), respectively. ICA calcification was independently associated with CMB of any location (odds ratio, OR, 2.86, 95% CI 2.01-4.08, p < 0.0001). The association between calcification and deep CMB was stronger (OR 3.51, 95% CI 2.39-5.14, p < 0.0001). However, ICA calcification was not associated with CMB in a strictly lobar area. Conclusion: ICA calcification is an independent risk factor for deep CMB but not for a strictly lobar CMB. Our findings might contribute to the elucidation of the pathogenesis of cerebral small vessel disease.

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Evaluation of Coronary Calcium Score by Multidetector Computed Tomography in Relation to Endothelial Function and Inflammatory Markers in Asymptomatic Individuals

Cited by 37 publications

References 42 publications

Association of inflammation and protein-energy wasting with endothelial dysfunction in peritoneal dialysis patients

Association of inflammation and protein-energy wasting with endothelial dysfunction in peritoneal dialysis patients

Epicardial Adipose Tissue Radiodensity Is Independently Related to Coronary Atherosclerosis - A Multidetector Computed Tomography Study -

Carotid Artery Calcification Is Associated with Deep Cerebral Microbleeds

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