Evaluation of Corneal Biomechanical Properties in Patients With Thyroid Eye Disease Using Ocular Response Analyzer

Moghimi, Sasan; Safizadeh, Mona; Mazloumi, Mehdi; Hosseini, Hamid; Vahedian, Zakieh; Rajabi, Mohammad Taher

doi:10.1097/ijg.0000000000000254

Cited by 24 publications

(17 citation statements)

References 26 publications

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“…Moghimi et al evaluated TED patients and reported the same findings as in the previous study. 14 These findings and our study results suggest that there is a strong relation between the autoimmune thyroid diseases -HT and GD. The etiology of HT and GD involves common pathways in which thyroid-reactive T cells escape tolerance and infiltrate the thyroid, and unique pathways in which these thyroid-reactive T cells either cause thyroid cell death (in HT) or stimulation (in GD).…”

Section: Discussionsupporting

confidence: 76%

“…[10][11][12] Because of the fact that one of the most important manifestations of TED is corneal and ocular surface involvement, investigators have studied alterations in corneal biomechanical properties in TED patients. 13,14 There are also some studies about corneal microstructural changes using corneal pachymetry and confocal biomicroscopy in GD. 15,16 To the best of our knowledge, alterations in corneal biomechanical properties in patients with HT have not been studied in detail before.…”

Section: Introductionmentioning

confidence: 99%

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Corneal biomechanical properties in patients with Hashimoto’s thyroiditis

et al. 2018

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Background. Hashimoto's thyroiditis (HT) is an autoimmune endocrine disorder that results from a dysregulation of the immune system leading to an immune attack on the thyroid gland. It has potential effects on different organs and tissues. Objectives. The aim of the study was to investigate the effect of HT on corneal biomechanical properties using the ocular response analyzer (ORA). Material and methods. A total of 48 patients with HT and 49 healthy subjects were enrolled in the study. The mean age of the patients and healthy subjects was 42.33 ±11.96 and 40.20 ±12.60 years, respectively (p = 0.39). All of the subjects underwent a full ophthalmological examination, including visual acuity, corneal pachymetry with topography, biomicroscopy, and funduscopy. Corneal biomechanical properties, including corneal hysteresis (CH) and corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal compensated IOP (IOPcc) were measured with the ORA. Results. Central corneal thickness (CCT) in the patient group and the control group were not significantly different (p = 0.65). Corneal hysteresis of the HT patients was significantly lower than that of the control group (p = 0.005). There were no statistically significant differences in CRF between the 2 groups (p = 0.53). Goldmann-correlated IOP and IOPcc were higher in the HT patients, but only IOPcc showed a statistically significant difference (p = 0.001). Conclusions. In conclusion, our data shows that HT affects corneal biomechanical properties by decreasing CH. Thus, IOPcc measured with the ORA should be taken into account when determining accurate IOP values in patients with HT.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Corneal biomechanical properties in patients with Hashimoto’s thyroiditis

et al. 2018

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“…This results were similar to those of ORA-based studies in which the CH level was lower in patients with TED than the control subjects. [ 17 18 19 ] The CH level was lower in ectatic corneal disorders,[ 20 21 ] and the lower CH level was realized as an independent risk factor for the glaucoma progression. [ 22 ] The inflammatory process in TED reduced the corneal damping ability[ 19 ] and could cause changes to the CH and HCDA.…”

Section: Discussionmentioning

confidence: 99%

“…However, the effects of the thyroid gland status on corneal biomechanical properties were not considered in previous reports in TED. [ 17 18 19 ]…”

Section: Discussionmentioning

confidence: 99%

Treatment-seeking behaviors of families for under five children in field practice area of jawaharlal nehru medical college, Wardha

Razeghinejad

Farsiani

Salout

et al. 2021

J Datta Meghe Inst Med Sci Univ

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PURPOSE: The purpose of this study is to compare the corneal biomechanical properties of hyperthyroids without ophthalmopathy (HWO), thyroid eye disease (TED), and euthyroid participants. METHODS: In this prospective comparative study, one eye per patient included in the analysis and according to exclusion criteria, 38 eyes of 40 HWO patients, 31 eyes of 40 TED patients, and 150 eyes of 160 age- and sex-matched euthyroid participants were enrolled. All participants were evaluated by an endocrinologist and oculoplastic surgeon for evaluation of thyroid function and orbitopathy, respectively. Measurements of corneal biomechanical properties were performed using ocular response analyzer and Corvis ST tonometers. RESULTS: In the HWO group, applanation-1 length (A1 L), applanation-2 velocity (A2V) ( P < 0.001), and corneal resistant factor ( P = 0.043) were higher than the control group and corneal hysteresis (CH) was lower ( P = 0.018). In the TED group, A1 L, A2V ( P < 0.001), and highest concavity radius (HCR) ( P = 0.027) were higher than the control group, and the CH ( P = 0.007) and highest concavity deformation amplitude (HCDA) ( P = 0.001) were lower. Furthermore, the level HCDA in the TED group was lower than HWO group ( P = 0.011). The level of upper scleral show and palpebral fissure had a negative correlation with CH and HCDA. The amount of exophthalmos level had a positive correlation with HCR. CONCLUSION: Corneal biomechanical properties in the HWO and TED groups were different from the normal euthyroid individuals and may be taken into account in managing situation like glaucoma and refractive surgeries.

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“…In the HKC, patients with keratoconus were included. The HKC includes also patients without obvious corneal abnormalities but with dysfunction of the thyroid gland, as thyroid disorders are suspected of leading to corneal biomechanical changes [ 7 ]. The diagnostic methods and goals of the HKC have been previously described in detail [ 8 – 10 ].…”

Section: Methodsmentioning

confidence: 99%

Complementary Keratoconus Indices Based on Topographical Interpretation of Biomechanical Waveform Parameters: A Supplement to Established Keratoconus Indices

Goebels

Eppig

Wagenpfeil

et al. 2017

Computational and Mathematical Methods in Medicine

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Purpose. To build new models with the Ocular Response Analyzer (ORA) waveform parameters to create new indices analogous to established topographic keratoconus indices. Method. Biomechanical, tomographic, and topographic measurements of 505 eyes from the Homburger Keratoconus Centre were included. Thirty-seven waveform parameters (WF) were derived from the biomechanical measurement with the ORA. Area under curve (ROC, receiver operating characteristic) was used to quantify the screening performance. A logistic regression analysis was used to create two new keratoconus prediction models based on these waveform parameters to resample the clinically established keratoconus indices from Pentacam and TMS-5. Results. ROC curves show the best results for the waveform parameters p1area, p2area, h1, h2, dive1, mslew1, aspect1, aplhf, and dslope1. The new keratoconus prediction model to resample the Pentacam topographic keratoconus index (TKC) was WFTKC = −4.068 + 0.002 × p2area − 0.005 × dive1 − 0.01 × h1 − 2.501 × aplhf, which achieves a sensitivity of 90.3% and specificity of 89.4%; to resample the TMS-5 keratoconus classification index (KCI) it was WFKCI = −3.606 + 0.002 × p2area, which achieves a sensitivity of 75.4% and a specificity of 81.8%. Conclusion. In addition to the biomechanically provided Keratoconus Index two new indices which were based on the topographic gold standards (either Pentacam or TMS-5) were created. Of course, these do not replace the original topographic measurement.

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Evaluation of Corneal Biomechanical Properties in Patients With Thyroid Eye Disease Using Ocular Response Analyzer

Abstract: In TED patients, CH seems to be lower than in normal subjects. GAT might underestimate the IOP due to differences in corneal properties of cornea in TED patients.

Cited by 24 publications

References 26 publications

Corneal biomechanical properties in patients with Hashimoto’s thyroiditis

Corneal biomechanical properties in patients with Hashimoto’s thyroiditis

Treatment-seeking behaviors of families for under five children in field practice area of jawaharlal nehru medical college, Wardha

Complementary Keratoconus Indices Based on Topographical Interpretation of Biomechanical Waveform Parameters: A Supplement to Established Keratoconus Indices

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