Evaluation of Cord Function in Cervical Spondylosis by a Combined Method Using Segmental and Conductive Spinal Evoked Potentials (SEP)

Kotani, H.; Hattori, Satoshi; Senzoku, F.; Kawai, Shinya; Saiki, K.; Yamasaki, Hironobu; Omote, Kanjiro

doi:10.1007/978-3-642-70687-5_34

Cited by 3 publications

(1 citation statement)

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“…The lateral half of the dorsal horn is also negative, whereas most of the ventral horn is electrically positive [149]. The mechanical distortion of the spinal cord followed by release of neurochemicals influence conduction of impulses due to altered synaptic transmission within the cord [44,[150][151][152][153][154][155]. Thus, changes in spinal cord conduction are not only the result of immediate mechanical disruption of tracts and "neuronal shock" but secondary injury factors and release of neurochemicals also play important roles [see 64,101,156,157].…”

Section: Spinal Cord Conduction and Cell Injury Following Scimentioning

confidence: 99%

Pathophysiology of Blood-Spinal Cord Barrier in Traumatic Injury and Repair

Sharma¹

2005

CPD

157

218

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Blood-spinal cord barrier (BSCB) plays an important role in the regulation of the fluid microenvironment of the spinal cord. Trauma to the spinal cord impairs the BSCB permeability to proteins leading to vasogenic edema formation. Several endogenous neurochemical mediators and growth factors contribute to trauma induced BSCB disruption. Studies carried out in our laboratory suggest that those drugs and neurotrophic factors capable to attenuate the BSCB dysfunction following trauma are neuroprotective in nature. Whereas, agents that do not exert any influence on the BSCB disruption failed to reduce cell injury. These observations are in line with the idea that BSCB disruption plays an important role in the pathophysiology of spinal cord injuries. The probable mechanism(s) of trauma induced BSCB dysfunction and its contribution to cell injuries are discussed.

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