Evaluation of copper nanoparticles on growth, organs histology and DNA damage in Japanese quails (
            <i>Coturnix coturnix japonica)</i>

Naz, Shabana; Raza, Naveed; Alhidary, Ibrahim; Satti, Sania; Rafique, Azhar; Batool, Sajida; Shamsi, Shamsuddin; Sifa, Dai; Khan, Rifat Ullah

doi:10.1080/15569543.2023.2298909

Cited by 3 publications

(1 citation statement)

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“…Nanoparticles provide an opportunity to provide enhanced bioavailability and therapeutic agents thorough high surface availability and size of the particles (Naz et al. 2024 ). Experiments have proved that nanoparticles showed better transport, uptake and absorption capacity (Aslam et al.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of biological selenium nanoparticles on growth performance, histopathology of vital organs and genotoxicity in Japanese quails ( coturnix coturnix japonica)

Naz,

Bibi,

Nadeem

et al. 2024

Veterinary Quarterly

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Research on the effects of selenium nanoparticles (Se-NPs), particularly in Japanese quails, is lacking, especially regarding the potential for DNA damage. Therefore, this study aimed to investigate the impact of administering 0.2 and 0.4 mg/kg of Se-NPs on the growth performance, DNA integrity, and histopathological alterations of the liver, lung, kidney, and heart in quails. A total of 480 one-day-old Japanese quails were divided into three experimental groups as follows: Group 1 served as the control and received only basic feed, while Group 2 and 3 received 0.2 mg/kg and 0.4 mg/kg of Se-NPs via oral gavage. Our results suggested that, birds fed with Se-NPs at both levels significantly ( p < .01) reduced feed intake, however, weight gain was significantly ( p < .01) increased in quails supplemented with 0.2 mg/kg. Similarly, feed conversion ratio (FCR) was significantly ( p < .01) reduced in group supplemented with 0.2 mg/kg Se-NPs. White blood cells increased significantly (P0.01) in 0.4 mg/kg while haemoglobin and red cell distribution width decreased ( p < .01) in the same group. Both treatment regimens resulted in DNA damage and histopathological alterations; however, the adverse effects were more prominent in the group receiving the higher dose of 0.4 mg/kg. These findings indicate that the lower dose of 0.2 mg/kg may have beneficial effects on growth. However, the higher dose of 0.4 mg/kg not only negatively impacts growth but also leads to histopathological alterations in major organs of the body and DNA damage as well.

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Section: Discussionmentioning

confidence: 99%