Evaluation of Contraceptive Potential of Isolated Fractions from Dendrophthoe falcata Stem Methanol Extract in Male Albino Rats

Phenolic Profiling and Evaluation of Contraceptive Effect of the Ethanolic Extract of Salsola imbricata Forssk. in Male Albino Rats

“…Since extreme abnormalities in sperms shapes and motility were noticed in the treated groups, these effects could be related to the ability of quercitrin to inhibit P-glycoprotein noncompetitively, thus rendering the sperms less protected against xenobiotics and toxins during spermatogenesis. Moreover, our findings are in agreement with those reported by Kachhawa et al [ 36 ] who confirmed the contraceptive potential of certain fractions of the methanolic extract of the stem of Dendrophthoe falcata , in male albino rats; the major constituent in D. falcata was identified as quercitrin. Furthermore, phenolic acids especially caffeic, coumaric, benzoic, and salicylic acids, which were also detected in the currently investigated extract, have well documented antifertility activities [ 32 , 44 – 46 ] and may thus contribute to the antifertility effect of the plant.…”

“…Taking in consideration all the previous findings, the observed antifertility effect of S. imbricata on male rats could be attributed to its phenolic constituents, especially quercitrin. As a matter of fact, these metabolites have been proven to produce antiandrogenic activity and to affect fertility in both male dogs and albino rats [ 31 , 36 , 37 ]. The flavonol glycoside quercitrin was prevailing (12.692%) among phenolics detected by HPLC in the methanolic extract.…”

Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

“…Compounds 2 , 3 , and 4 were all previously isolated from DF ( Nair and Krishnakumary, 1990 ; Mallavadhani et al, 2006 ; Kachhawa J. et al, 2011 ) and DP ( Artanti et al, 2006 ; Nguyen et al, 2010 ; Rahmawati et al, 2014 ; Sembiring et al, 2022 ). Furthermore, quercetagetin ( 5 ), meratin ( 6 ), hyperoside ( 7 ), kaempferol ( 8 ), and apigenin-8-C- β -D-(2″- O - β -D-glucopyranosyl)-glucopyranoside ( 9 ), were previously isolated only from DF ( Nair and Krishnakumary, 1990 ; Gangwar and Saxena, 2010 ; Kachhawa J. et al, 2011 ; Khatoon et al, 2011 ). Quercetin 4′- O - β -glucopyranoside ( 10 ) and hesperidin ( 11 ) were previously separated only from DP ( Nguyen et al, 2010 ; Rahmawati et al, 2014 ).…”

“…Common flavonoids such as quercetin ( 1 ), quercitrin ( 2 ), rutin ( 3 ), and kaempferol 3- O - α -L-rhamnopyranoside ( 4 ) have been yielded from DF and DP. Among them, compound 1 was previously yielded from DF ( Nair and Krishnakumary, 1990 ; Kachhawa J. et al, 2011 ) and DP ( Artanti et al, 2006 ; Rahmawati et al, 2014 ). Compounds 2 , 3 , and 4 were all previously isolated from DF ( Nair and Krishnakumary, 1990 ; Mallavadhani et al, 2006 ; Kachhawa J. et al, 2011 ) and DP ( Artanti et al, 2006 ; Nguyen et al, 2010 ; Rahmawati et al, 2014 ; Sembiring et al, 2022 ).…”

“…Among them, compound 1 was previously yielded from DF ( Nair and Krishnakumary, 1990 ; Kachhawa J. et al, 2011 ) and DP ( Artanti et al, 2006 ; Rahmawati et al, 2014 ). Compounds 2 , 3 , and 4 were all previously isolated from DF ( Nair and Krishnakumary, 1990 ; Mallavadhani et al, 2006 ; Kachhawa J. et al, 2011 ) and DP ( Artanti et al, 2006 ; Nguyen et al, 2010 ; Rahmawati et al, 2014 ; Sembiring et al, 2022 ). Furthermore, quercetagetin ( 5 ), meratin ( 6 ), hyperoside ( 7 ), kaempferol ( 8 ), and apigenin-8-C- β -D-(2″- O - β -D-glucopyranosyl)-glucopyranoside ( 9 ), were previously isolated only from DF ( Nair and Krishnakumary, 1990 ; Gangwar and Saxena, 2010 ; Kachhawa J. et al, 2011 ; Khatoon et al, 2011 ).…”