Purpose. The aim of this study was to assess the activity and toxicity of primary carboplatin-based chemoradiotherapy (CarboRT) Implications for Practice: Cisplatin-based chemoradiotherapy (CisRT) has been regarded as the standard treatment for patients with locally advanced cervical cancer. Cisplatin, however, can cause nephrotoxicity, has highly emetogenic effects, and creates the need for a large amount of hydration. Carboplatin-based chemoradiotherapy was better tolerated than CisRT without compromising tumor response and survival in patients with locally advanced cervical cancer and poor general condition.