Evaluation of commercially available biodegradable tetracycline fiber therapy in chronic periodontitis

Abstract

Background:Chronic periodontitis is an inflammatory disorder caused by dental plaque having mixed microbial flora. The different treatment modalities available to treat this disease are aimed at removal of micro-organisms from both hard and soft tissues. Systemic as well as local anti-microbial agents are helpful adjuncts in reducing microbes especially in inaccessible areas along with mechanical debridement therapy.Materials and Methods:The study was conducted in a split mouth design. Thirty-five patients having at least two non-adjacent sites in different quadrants with periodontal pockets ≥5 mm and with bleeding on probing at initial visit were selected. The selected sites were treated with both scaling and root planing plus tetracycline fibers or with scaling and root planing alone. Baseline and follow-up measurements included plaque index, gingival index, probing pocket depth, and clinical attachment level.Result:Both treatment modalities were affective in improving clinical parameters over three months’ observation period. The combined antimicrobial and mechanical debridement therapy has shown better results as compared with scaling and root planing alone.Conclusion:Application of tetracycline in modified collagen matrix following scaling and root planing might be beneficial in treatment of chronic periodontitis and improving periodontal parameters for 3-month duration.

Tetracycline as local drug delivery in treatment of chronic periodontitis: A systematic review and meta-analysis

“…[ 2 9 10 11 13 17 18 19 20 ] Seven articles were retrieved after electronic search of medical database and included for reading full text[ 2 11 12 14 19 20 21 ] and four articles were included after hand search. [ 9 10 13 18 ] Unpublished data of two studies were obtained from approval letter available at center for drug evaluation and research, USA. [ 17 ] Three articles were excluded for the reason as no random concealed allocation or blinding done,[ 14 ] cases of aggressive periodontitis were also included[ 12 ] and results of control group not available [ Figure 1 ].…”

“…Two out of ten included studies were conducted in USA[ 17 ] and one in Brazil;[ 18 ] others were conducted in India. [ 2 9 10 11 13 19 20 ] The number of sites in studies ranged from 13 to 140. The age of the subjects included ranged from 20 to 75 years.…”

“…Of ten included studies, only one had used doxycycline as LDD,[ 20 ] six studies had used 2% minocycline gel[ 2 13 17 18 19 ] where remaining three had used 8% tetracycline fibers. [ 9 10 11 ] Follow-up period varies from 3 to 9 months [ Table 2 ]. Seven studies evaluated PD after 3 months, five did follow-up for 6 months and four followed up the participants for 9 months.…”

“…Recent trials[ 2 9 10 11 12 13 14 15 ] evaluated sustained release system incorporating tetracycline gave promising results except one study,[ 2 ] but pooling of data of such trials and its quality assessment is required before implementing in clinical practice.…”

Comparação entre dois métodos de descontaminação da superfície de implantes na re-osseointegração após a periimplantite induzida por ligadura. Estudo histomorfométrico e microbiológico em cães

“…A maior parte desses agentes são utilizados na superfície radicular devido às suas propriedade quelantes, de remoção da smear layer e exposição das fibras colágenas dentinárias (Wikesjo et al, 1986), o uso em implantodontia justifica-se devido a propriedade de remoção de debris remanescentes da limpeza mecânica. O cloridrato de tetraciclina, em particular, apresenta substantividade antimicrobiana (Stabholz et al, 1993a, Stabholz et al, 1993b, sendo usado, por vezes, como antimicrobiano local (Sachdeva and Agarwal, 2011).…”