Evaluation of commercial skin prick test solutions for selected occupational allergens

Kampen, V. van; Blay, F. De; Folletti, Ilenia; Kobierski, P.; Moscato, Gianna; Olivieri, Mario; Quirce, Santiago; Sastre, Joaquı́n; Walusiak‐Skorupa, Jolanta; Kotschy-Lang, N.; Müsken, H.; Mahler, Vera; Schliemann, Sibylle; Ochmann, Uta; Sültz, J.; Worm, Margitta; Sander, I.; Zahradnik, Eva; Brüning, Thomas; Merget, R.; Raulf‐Heimsoth, Monika

doi:10.1111/all.12116

Cited by 75 publications

(41 citation statements)

References 23 publications

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“…Common allergens used in SPT were: house dust mite Dermatophagoides pteronyssinus, animal dander mix I, grass/cereals pollen mix, tree pollen mix I, tree pollen mix II and weed pollen mix (Allergopharma, Germany). The farm work-specific allergens included storage mites Acarus siro, Lepidoglyphus destructor, Tyrophagus putrescentiae, cow epithelium, pig epithelium, horse epithelium and hay dust (Allergopharma), as well as grain dust, straw dust, and hay dust (Biomed, Poland), in line with previous research [10] and availability of commercial allergen preparations at the time of the study [11]. Each school was visited once, a follow-up was not attempted as the participants were last-year vocational students who were about to leave the schools through which they were recruited.…”

Section: Methodssupporting

confidence: 72%

Risk factors for work-related eczema and urticaria among vocational students of agriculture

Śpiewak¹,

Góra-Florek²,

Horoch³

et al. 2017

Ann Agric Environ Med.

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Introduction and objective. Farmers are at high risk of occupational skin diseases which may start already during vocational training. This study was aimed at identification of risk factors for work-related skin diseases among vocational students of agriculture. Materials and method. The study involved 440 students (245 males, 195 females aged 17-21 years) in 11 vocational schools which were at least 100 km from each other. The protocol included a physician-managed questionnaire and medical examination, skin prick tests, patch tests, total IgE and Phadiatop. Logistic regression model was used for the identification of relevant risk factors. Results. Work-related dermatoses were diagnosed in 29 study participants (6.6%, 95%CI: 4.3-8.9%): eczema in 22, urticaria in 14, and co-existence of both in 7 students. Significant risk factors for work-related eczema were: history of respiratory allergy (OR=10.10; p<0.001), history of eczema (itchy rash) provoked by wet work and detergents before entering the school (OR=5.85; p<0.001), as well as history of contact dermatitis to metals, rubber or cosmetics prior to inscription (OR=2.84; p=0.016), and family history of any skin disease (OR=2.99; p=0.013). Significant risk factors for work-related urticaria were: history of allergic rhinitis and asthma prior to inscription (OR=7.29; p=0.006), positive skin prick tests to work place allergens (OR=4.65; p=0.002) and to environmental allergens (OR=3.79; p=0.009), and positive Phadiatop test (OR=3.61; p=0.013). Conclusions. Work-related skin diseases are common among vocational students of agriculture. Atopy, past history of asthma, allergic rhinitis, and eczema (either atopic, allergic or irritant) are relevant risk factors for work-related eczema and urticaria in young farmers, along with family history of any skin disease. Positive skin prick tests seem relevant, especially in the case of urticaria. Asking simple, aimed questions during health checks while enrolling students into agricultural schools would suffice to identify students at risk for work-related eczema and urticaria, giving them the chance for selecting a safer profession, and hopefully avoiding an occupational disease in the future.

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Section: Methodssupporting

confidence: 72%

Risk factors for work-related eczema and urticaria among vocational students of agriculture

Śpiewak¹,

Góra-Florek²,

Horoch³

et al. 2017

Ann Agric Environ Med.

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“…This retrospective study includes all bakers who had been previously examined within a European multicentre study for the standardization of the diagnosis for occupational allergy (STADOCA) with the aim to improve the diagnosis of occupational allergy [19]. During the STADOCA project, allergologists collected sera and data from all patients who were examined within the scope of claims for compensation due to occupational asthma in the 15 participating European allergy centres.…”

Section: Methodsmentioning

confidence: 99%

IgE Sensitization to Lupine in Bakers - Cross-Reactivity or Co-Sensitization to Wheat Flour?

Kampen

Sander

Quirce

et al. 2015

Int Arch Allergy Immunol

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Background: Food allergy to lupine has frequently been reported in patients allergic to peanut or soy, and cross-reactivity between these legumes is known. Moreover, respiratory allergy to lupine has been described after inhalation, mostly at workplaces. Our aim was to study the frequency of lupine sensitization in European bakers with suspected bakers' allergy. Furthermore, associations between sensitizations to lupine and other plant allergens were investigated. Methods: One hundred and sixteen bakers with work-related allergic symptoms but without known food allergies were examined. Specific IgE (sIgE) antibodies to wheat flour, rye flour, lupine, peanut, soy and the recombinant single birch protein rBet v 1 were quantified. Selected sera were tested for cross-reactivity using ImmunoCAP inhibition and ISAC microarrays. Results: Whereas 67% of bakers were sensitized to wheat and/or rye flour, 35% showed sIgE to peanut and 33% to lupine. All lupine-positive bakers also had sIgE to either wheat flour (89%) and/or peanut (92%), and lupine sIgE correlated significantly with sIgE to peanut, soy, wheat and rye flour. Used as an inhibitor, wheat flour inhibited IgE binding to lupine in 4 out of 8 sera, indicating cross-reactivity. In microarrays, these sera showed IgE binding to lipid transfer proteins, profilins and/or cross-reactive carbohydrate determinants. Further inhibition experiments suggest that these single allergens are involved in cross-reactivity. Conclusion: One third of 116 symptomatic bakers showed sIgE to lupine. At least some of these sensitizations were based on cross-reactivity between lupine and wheat flour. However, the considerable sensitization rate could also be a sign that the use of lupine flour in bakeries may be of occupational relevance.

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“…Determination of skin and serum-specific immunoglobulin E (sIgE) antibodies demonstrates the sensitization to allergens; however, commercially available standardized tests are prepared only for a few occupational allergens [48, 49]. Detection of sIgE has the highest specificity of 79% in diagnosing OA induced by HMW-A and confirmed by SIC [50].…”

Section: Assessment Of Biomarkers In Skin and Blood Samplesmentioning

confidence: 99%

Usefulness of Biomarkers in Work-Related Airway Disease

Lipińska‐Ojrzanowska

Marcinkiewicz

Walusiak‐Skorupa

2017

Curr Treat Options Allergy

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Opinion statementDetermination of biomarkers may be useful in the surveillance of occupational exposure and workers’ health. The possibility of predicting development/clinical course of specific disorders or current disease, diagnosing in early steps, and health condition monitoring is a real necessity. Various agents present in the workplace environment (or their metabolites) can be measured in samples possessed from human body (blood and urine, saliva, etc.). On the other hand, inhalant exposure may induce specific or non-specific, local or systemic, acute or chronic biological response expressed by synthesis or releasing specific or non-specific substances/mediators that also can be determined in blood, nasal and bronchial lavage or sputum, tear fluid, exhaled breath, etc. The least is known about genetic markers which may predict individual susceptibility to develop some work-related disorders under the influence of occupational exposure. Due to common exposure to inhalant agents at workplace, researches on biomarkers that allow to inspect the impact of exposure to humans’ health are still needed. The authors of this article summarize the utility of biomarkers’ determination in work-related airway diseases in a recent clinical approach.

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Evaluation of commercial skin prick test solutions for selected occupational allergens

Abstract: There is a wide variability of SPT solutions for occupational allergens, and the sensitivity of several solutions is low. Thus, improvement and standardization of SPT solutions for occupational allergens is essential.

Cited by 75 publications

References 23 publications

Risk factors for work-related eczema and urticaria among vocational students of agriculture

Risk factors for work-related eczema and urticaria among vocational students of agriculture

IgE Sensitization to Lupine in Bakers - Cross-Reactivity or Co-Sensitization to Wheat Flour?

Usefulness of Biomarkers in Work-Related Airway Disease

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