Evaluation of Combined Topical Ozone and Steroid Therapy in Management of Oral Lichen Planus

Abstract

AIM:The present study aims to assess the therapeutic effect of the combination of topical ozone and steroid therapy in comparison to topical ozone alone versus topical steroid as a control in the management of atrophic - erosive oral lichen planus (OLP).METHODS:Sixty-six patients are having atrophic-erosive OLP were included in the study. They were randomly divided into three equal groups to be treated with topical corticosteroids alone (steroid group) as control, topical ozone alone (ozone group) or combination of topical steroids and ozone (combined group). Assessment of pain and sign scores was done before and after each treatment modality.RESULTS:The results revealed that the greatest significant percentage of change and subsequent improvement in pain and sign scores were recorded in the combined group.CONCLUSION:Reported data in this study using the combination of ozone and steroid therapy could provide a new promising safe and effective adjunct therapy for management of OLP.

Clinical Management Protocol for Dental Implants Inserted in Patients with Active Lichen Planus. Part II 4‐Year Follow‐Up

“…Reticular type is the most common type, and has characteristic interlacing white lines called Wickham striae . Reticular/keratotic, plaque, and papular are known as white keratotic or nonerosive oral lichen planus (NEOLP), also known as reticular‐papular type . Erosive/atrophic, ulcerative and bullous are known as white and red lesions, or as erosive oral lichen planus (EOLP), also known as predominantly red form .…”

“…Reticular/keratotic, plaque, and papular are known as white keratotic or nonerosive oral lichen planus (NEOLP), also known as reticular‐papular type . Erosive/atrophic, ulcerative and bullous are known as white and red lesions, or as erosive oral lichen planus (EOLP), also known as predominantly red form . Sometimes more than one type may occur in the same patient.…”

“…CD4 helper T cells are activated by an unknown antigen, which secrets cytokines and interleukins that recruit Langerhans and CD8 cytotoxic T cells . Cytotoxic T cells trigger apoptosis of the basal cells (target cells) …”

“…Corticosteroids are the main treatment for symptomatic OLP . Topical steroids are considered first‐line treatment because they are more effective treating superficial inflammation, specially in EOLP .…”

“…The therapeutic potential of photodynamic therapy, lasers, and cold atmospheric plasma (CAP) are currently being evaluated . Ozone therapy is also being used to treat OLP due to its strong antimicrobial activity …”