Evaluation of column extraction: A new procedure for the analysis of drugs in body fluids

Determination of several psychiatric drugs in whole blood using capillary gas–liquid chromatography with nitrogen phosphorus detection: comparison of two solid phase extraction procedures

“…The aqueous sample is added to the top of the column, adsorbed, and distributed into a film over the diatomaceous earth, which is an hydrophilic packing porous material which acts as support for the aqueous phase. The high surface area of the inert diatomaceous earth ensures that the organic eluents remain immiscible with the aqueous matrix, eliminating emulsion problems, and facilitating efficient interaction between the sample and the organic solvent [24,25]. However, for STA purposes where acidic, neutral, and basic substances may be present, this type of SPE must be carried out with at least two columns: one for the acidic and neutral substances and one for basic and neutral substances and often large volumes of hazardous organic solvents are required [2].…”

Determination of phosphatidylethanol 16:0/18:1 in whole blood by 96‐well supported liquid extraction and UHPLC‐MS/MS

“…Recently, Andreassen et al described a high throughput UHPLC‐MS/MS method for determination of PEth 16:0/18:1 in whole blood using 96‐well PPT with 2‐propanol as organic solvent. Supported liquid extraction (SLE) is another technique that that is fast and easy which can be used for isolation of different compounds from biological samples, and a technique that often generates cleaner extracts than what is obtained by PPT . By 96‐well SLE, the sample preparation time and the need for manual interventions can be significantly reduced compared to single vial LLE, SPE, SLE, and PPT .…”

Zum screening der benzo- und thienodiazepine im urin mit dem emit ST und der DC im rahmen eines suchtestes auf medikamentenmi�brauch

“…Als Suchprogramm fiir die Erkennung eines Medikamentenmigbrauchs hat sich die Diinnschichtchromatografie bew~ihrt [1][2][3][4]. Deshalb ist dem Nachweis yon Benzodiazepinen im Rahmen eines Screeningprogramms zur Diagnostik yon Vergiftungen besondere Beachtung zu widmen.…”