Evaluation of cognitive functions of juvenile myoclonic epileptic patients by magnetic resonance spectroscopy and neuropsychiatric cognitive tests concurrently

Cevik, Nesrin; Koksal, Ayhan; Dogan, Vasfiye Burcu; Dırıcan, Ayten Ceyhan; Bayramoğlu, Sibel; Öztürk, Musa; Baybaş, Sevim

doi:10.1007/s10072-015-2425-5

Cited by 13 publications

(12 citation statements)

References 7 publications

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“…In our cohort, neuropsychological evaluation profiles often shown mild widespread malfunctioning and executive dysfunction, in concordance with previous reports that people with JME have executive and attention issues characterized by deficits in mental flexibility, planning, concept formation, inhibitory control, attentional processes, memory, visuospatial function and verbal fluency [28][29][30][31] . In our sample, there were no group differences on neuropsychological evaluation.…”

Section: Discussionsupporting

confidence: 92%

Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center

Cação

Parra

Mannan

et al. 2018

Epilepsy & Behavior

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Section: Discussionsupporting

confidence: 92%

Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center

Cação

Parra

Mannan

et al. 2018

Epilepsy & Behavior

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“…Although most MRS studies of JME have demonstrated reduced NAA concentrations or NAA/Cr ratios in the thalamus, the methods applied have varied between single- and multi-voxel measurements, as well as between short and long echo times ( 9 , 10 , 15 , 20 - 24 ) . We also found NAA values to be lower in JME patients than in controls, although the difference did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 99%

“…When using short echo times, most authors have shown significantly lower NAA concentrations in the frontal lobe or thalamus of patients with JME ( 8 , 9 , 15 , 17 , 20 , 21 , 24 ) . Araújo Filho et al ( 10 ) found a lower NAA/Cr ratio in the thalamus.…”

Section: Discussionmentioning

confidence: 99%

Proton spectroscopy of the thalamus in a homogeneous sample of patients with easy-to-control juvenile myoclonic epilepsy

et al. 2017

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ObjectiveJuvenile myoclonic epilepsy (JME) is a subtype of genetically determined generalized epilepsy that does not present abnormalities on conventional magnetic resonance imaging. The aim of this study was to identify metabolic alterations in the thalamus in a clinically homogeneous sample of patients with easy-to-control JME, using short-echo time proton magnetic resonance spectroscopy (MRS).Materials and MethodsWe performed single-voxel (2 cm × 2 cm × 2 cm), short-echo time (TE = 35 ms) proton MRS of the thalamus in 21 patients with JME and in 14 healthy age-matched controls. We quantified N-acetylaspartate (NAA), total NAA, creatine (Cr), choline, and myo-inositol (MI), as well as the sum of glutamate and glutamine signals, all scaled to internal water content, and we calculated metabolite ratios using Cr as a reference. Values of p < 0.05 were considered significant.ResultsThe MI level and the MI/Cr ratio were significantly lower in the thalami of patients diagnosed with JME than in those of the controls. Other metabolites and their ratios did not differ significantly between the two groups.ConclusionIn our sample of 21 JME patients, we identified lower levels of MI in the thalamus. No significant abnormalities were observed in the concentrations or ratios of other metabolites.

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“…9,10 One of the hallmarks of this idiopathic syndrome is that brain structural abnormalities are not found on routine magnetic resonance imaging (MRI) studies. 11 However, when brain integrity is investigated with quantitative techniques, a diversity of abnormalities has been reported in, for example, brain structure, metabolism, connectivity, and function, 4,[11][12][13] with several of these abnormalities linked to disrupted cognition, 4,6,[13][14][15] attesting to their clinical significance. There are very few prospective investigations of cognitive and brain developmental course in youth with new-or recent-onset JME.…”

Section: Introductionmentioning

confidence: 99%

Progressive dissociation of cortical and subcortical network development in children with new‐onset juvenile myoclonic epilepsy

Garcia‐Ramos

Dabbs²,

Lin

et al. 2018

Epilepsia

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Objectives: Structural and functional MRI studies have consistently documented cortical and subcortical abnormalities in patients with Juvenile Myoclonic Epilepsy (JME). However, little is known about how these structural abnormalities emerge from the time of epilepsy onset and how network interactions between and within cortical and subcortical regions may diverge in youth with JME compared to typically developing children. Methods: We examined prospective co-variations of volumetric differences derived from high resolution structural MRI during the first two years of epilepsy diagnosis in a group of youth with JME (n=21) compared to healthy controls (n=22). We indexed developmental brain changes using graph theory by computing network metrics based on the correlation of the cortical and subcortical structural covariance near the time of epilepsy and two years later. Results: Over two years, normally developing children showed modular cortical development and network integration between cortical and subcortical regions. In contrast, children with JME developed a highly correlated and less modular cortical network, which was atypically dissociated from subcortical structures. Furthermore, the JME group also presented higher clustering and lower modularity indices than controls, indicating weaker modules or communities. The local efficiency in JME was higher than controls across the majority of cortical nodes. Regarding network hubs, controls presented a higher number than youth with JME that were spread across the brain with ample representation from the different modules. In contrast, children with JME showed a lower number of hubs that were mainly from one module and were comprised mostly of subcortical structures. Significance: Youth with JME prospectively developed a network of highly correlated cortical regions dissociated from subcortical structures during the first 2 years of epilepsy onset. The cortical-subcortical network dissociation provides converging insights on the disparate literature of cortical and subcortical abnormalities found in previous studies.

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Evaluation of cognitive functions of juvenile myoclonic epileptic patients by magnetic resonance spectroscopy and neuropsychiatric cognitive tests concurrently

Cited by 13 publications

References 7 publications

Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center

Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center

Proton spectroscopy of the thalamus in a homogeneous sample of patients with easy-to-control juvenile myoclonic epilepsy

Progressive dissociation of cortical and subcortical network development in children with new‐onset juvenile myoclonic epilepsy

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