Evaluation of Cognitive Functioning Before and After Cochlear Implantation in Adults Aged 55 Years and Older at Risk for Mild Cognitive Impairment

Andries, Ellen; Bosmans, Joyce; Engelborghs, Sebastiaan; Cras, Patrick; Vanderveken, Olivier M.; Lammers, Marc J. W.; Heyning, P.H. Van de; Rompaey, Vincent Van; Mertens, Griet

doi:10.1001/jamaoto.2022.5046

Cited by 10 publications

(13 citation statements)

References 40 publications

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“…According to current findings, central inflammatory response can disrupt neurocytes to cause the occurrence of POCD, which resembles the case of degenerative diseases. Meanwhile, POCD also presents with oxidative stress damage, aging iron deposition, etc 3,4 . Reactive astrocytes (RAs) play an important role in regulating central nervous system diseases, which are fairly heterogeneous 5 and can be classified into different types 6 .…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, POCD also presents with oxidative stress damage, aging iron deposition, etc. 3 , 4 Reactive astrocytes (RAs) play an important role in regulating central nervous system diseases, which are fairly heterogeneous 5 and can be classified into different types. 6 In neuroinflammation, RAs can be divided into A1 and A2 phenotypes.…”

Section: Introductionmentioning

confidence: 99%

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TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3‐mediated A1 differentiation of astrocytes

et al. 2023

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AimWe investigated the mechanism, whereby tumor necrosis factor‐like ligand 1A (TL1A) mediates the A1 differentiation of astrocytes in postoperative cognitive dysfunction (POCD).MethodsThe cognitive and behavioral abilities of mice were assessed by Morris water maze and open field tests, while the levels of key A1 and A2 astrocyte factors were detected by RT‐qPCR. Immunohistochemical (IHC) staining was used to examine the expression of GFAP, western blot was used to assay the levels of related proteins, and enzyme‐linked immunosorbent assay (ELISA) was used to detect the levels of inflammatory cytokines.ResultsThe results showed that TL1A could promote the progression of cognitive dysfunction in mice. Astrocytes differentiated into A1 phenotype, while unobvious changes were noted in astrocyte A2 biomarkers. Knockout of NLRP3 or intervention with NLRP3 inhibitor could inhibit the effect of TL1A, improving the cognitive dysfunction and suppressing the A1 differentiation.ConclusionOur results demonstrate that TL1A plays an important role in POCD in mice, which promotes the A1 differentiation of astrocytes through NLRP3, thereby exacerbating the progression of cognitive dysfunction.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3‐mediated A1 differentiation of astrocytes

et al. 2023

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“…It is therefore important to question hearing aid use and include it as a variable in the study protocol. Even though wearing hearing aids or a cochlear implant seems to have positive effects on cognitive performance and thus decreasing the risk of developing dementia,4 28–30 there is currently no cure or disease-modifying therapy available to prevent SNHL, BV and cognitive decline in patients with DFNA9.…”

Section: Discussionmentioning

confidence: 99%

“…While there is still no cure for dementia, it is important to adequately treat its modifiable risk factors, such as hearing loss. By doing so, the risk of developing dementia can be decreased by 9.1% 4 28–30. While treatment is currently focused on hearing rehabilitation with hearing aids and cochlear implants, emerging alternatives are based on gene therapy to prevent or restore hearing permanently.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of hearing levels and vestibular function and the impact on cognitive performance in (pre)-symptomatic patients with DFNA9: protocol for a prospective longitudinal study (Rosetta study)

Gommeren,

Moyaert,

Bosmans

et al. 2023

BMJ Open

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IntroductionUntreated hearing loss is the largest potentially modifiable risk factor for dementia. Additionally, vestibular dysfunction has been put forward as a potential risk factor for accelerated cognitive decline. Patients with Deafness Autosomal Dominant 9 (DFNA9) present with progressive sensorineural hearing loss and bilateral vestibulopathy and show significantly worse results in cognitive performance compared with a cognitively healthy control group. This highlights the need for adequate treatment to prevent further cognitive decline. This study aims to determine how hearing and vestibular function evolve in (pre-)symptomatic carriers of the p.Pro51Ser mutation in theCOCHgene and how this impacts their cognitive performance and health-related quality of life.Methods and analysisA prospective, longitudinal evaluation of hearing, vestibular function and cognitive performance will be acquired at baseline, 1-year and 2-year follow-up. A total of 40 patients with DFNA9 will be included in the study. The study will be a single-centre study performed at the ORL department at the Antwerp University Hospital (UZA), Belgium. The control group will encompass cognitively healthy subjects, already recruited through the GECkO study. The primary outcome measure will be the Repeatable Battery for the Assessment of Neuropsychological Status adjusted for the Hearing-Impaired total score. Secondary outcome measures include Cortical Auditory-Evoked Potentials, vestibular assessments and health-related quality of life questionnaires. The expected outcomes will aid in the development of gene therapy by providing insight in the optimal time window for the application of gene therapy for the inner ear.Ethics and disseminationThe ethical committee of UZA approved the study protocol on 19 December 2022 (protocol number B3002022000170). All participants have to give written initial informed consent in accordance with the Declaration of Helsinki. Results will be disseminated to the public through conference presentations, lectures and peer-reviewed scientific publications.

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“…So kommt es innerhalb von nur wenigen Monaten zu einer signifikanten Verbesserung der Lebensqualität und der kognitiven Leistungsfähigkeit. Es finden sich in der aktuellen Literatur zudem Hinweise für einen über viele Jahre stabilen Zugewinn in diesen Bereichen [15,16,17,18,19,20,21,22].…”

Section: Introductionunclassified

Eine Cochlea-Implantat-Versorgung reduziert langfristig die Tinnitusbelastung bei älteren Patienten

Issing,

Loth,

Sakmen

et al. 2024

Laryngorhinootologie

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Zusammenfassung Hintergrund Tinnitus gehört bei hochgradig schwerhörigen bzw. ertaubten Patienten zu den häufigsten otologischen Komorbiditäten. Das Cochlea-Implantat (CI) kommt vermehrt auch bei älteren Patienten zur Hörrehabilitation erfolgreich zum Einsatz. Ziel dieser Nachuntersuchung war die Beurteilung der Tinnitusbelastung im Langzeitverlauf bei älteren Patienten nach Hörrehabilitation mittels CI. Material und Methode In diese prospektive longitudinale Untersuchung konnten 15 Patienten zwischen dem 72. und 92. Lebensjahr mit einem präoperativen unstillbaren Tinnitus eingeschlossen werden, die vor etwa 6 Jahren erstmalig unilateral mit einem CI versorgt wurden. Es erfolgte die Erhebung des Einsilbersprachverstehens sowie der Tinnitusbelastung mithilfe des Mini-Tinnitus-Fragebogens. Die Ergebnisse wurden mit unserer vorangegangenen Untersuchung 24, in der wir die ersten 6 Monate nach CI-Versorgung betrachteten, verglichen. Ergebnisse Sechs Jahre postoperativ kam es zu einer nicht signifikanten Zunahme des Einsilbersprachverstehens auf 61,7±26,3%, verglichen mit den Ergebnissen 6 Monate postoperativ (p=0,069). Die Belastung durch den Tinnitus zeigte sich 6 Jahre postoperativ mit 3,9±3,6 Punkten im Mittel, verglichen mit der 6-Monats-Kontrolle, stabil niedrig (p=0,689) und deutlich reduziert zum präoperativen Status mit 6,9±6,5 Punkten (p=0,016). Schlussfolgerung Die Hörrehabilitation mit CI führt bei älteren Menschen zu einer anhaltenden Verbesserung der Einsilberdiskrimination und zu einer langfristigen Reduktion der Tinnitusbelastung.

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Evaluation of Cognitive Functioning Before and After Cochlear Implantation in Adults Aged 55 Years and Older at Risk for Mild Cognitive Impairment

Cited by 10 publications

References 40 publications

TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3‐mediated A1 differentiation of astrocytes

TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3‐mediated A1 differentiation of astrocytes

Evaluation of hearing levels and vestibular function and the impact on cognitive performance in (pre)-symptomatic patients with DFNA9: protocol for a prospective longitudinal study (Rosetta study)

Eine Cochlea-Implantat-Versorgung reduziert langfristig die Tinnitusbelastung bei älteren Patienten

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