Evaluation of Clotting and Fibrinolytic Activation after Protracted Physical Exercise

Prisco, Domenico; Paniccia, Rita; Bandinelli, Brunella; Fedi, Sandra; Cellai, Anna Paola; Liotta, Agatina Alessandrello; Gatteschi, Luca; Giusti, Betti; Colella, Andrea; Abbate, Rosanna; Gensini, Gian Franco

doi:10.1016/s0049-3848(97)00293-4

Cited by 73 publications

(56 citation statements)

References 34 publications

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“…26 Moreover, in this study, a significant increase in the blood fibrinogen level in female athletes' blood samples was seen following an acute exhausting aerobic training session by both groups. These findings are in agreement with the reports by Ahmadizad et al and Prisco et al 27,28 In contrast, the findings of some researchers (e.g., Rankinen et al 29 ) were not similar to our results. These differences in fibrinogen may be due to the differences in the type and severity of the protocol.…”

Section: Discussionsupporting

confidence: 88%

The Effect of Acute Training and Circadian Rhythm on Blood Hemostasis in Female Athletes

Mahmoodinezhad¹,

Shakerian²,

Ghalavand³

et al. 2016

Int J Basic Sci Med

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Background: Circadian rhythm and physical activity are factors that influence the homeostasis of blood. This study aimed to investigate the effect of exhaustive exercise in the morning and evening on the blood hemostasis in female athletes. Methods: In the present quasi-experimental study, 30 female athletes aged 18-25 were selected by convenience sampling method and randomly divided into two groups (morning and afternoon exercises). The standard Bruce protocol test was used. In the present study, platelets, fibrinogen, and thromboplastin time were measured as indicators of blood coagulation before and after testing. Paired t-test and covariance analysis were used to analyze the measured indices and P ≤ 0.05 was considered significant. Results: An acute exhausting aerobic training session in both groups significantly increased platelet and fibrinogen levels, but a significant decrease was observed in thromboplastin time. Considering the training time, significant difference was observed in the blood thromboplastin time in the morning in comparison with the afternoon. Conclusion: According to the results of this study, the circadian rhythm and acute exhausting aerobic training are effective factors on the blood coagulation and a training session in the morning compared with the evening training has a greater effect on the blood coagulation.

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Section: Discussionsupporting

confidence: 88%

The Effect of Acute Training and Circadian Rhythm on Blood Hemostasis in Female Athletes

Mahmoodinezhad¹,

Shakerian²,

Ghalavand³

et al. 2016

Int J Basic Sci Med

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“…Fibrinogen level also did not change in both protocols used in the present study, suggesting that fibrinogen is not consumed in our experimental conditions. The end products of fibrinolysis, fibrin degradation products (FDP), and D-D, products of the breakdown of activated factor 8 (fibrin stabilizing factor) have been reported to increase after heavy endurance exercises of different types (Arai et al, 1990;Molz et al, 1993;Prisco et al, 1998). However, in the present study, FDP and D-D did not significantly change.…”

Section: Discussioncontrasting

confidence: 81%

Effects of KAATSU training on haemostasis in healthy subjects

Nakajima

Takano

Kurano

et al. 2007

Int. J. KAATSU Ttaining Res.

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Purposes: The KAATSU training is performed under the reduction of muscle blood flow by a speciallydesigned belt (KAATSU belt), which induces blood pooling in capacitance vessels by restricting venous return. However, no prior studies have examined the effects of KAATSU training on haemostasis. The purpose of the present study was to investigate acute effects of KAATSU training on haemostasis including fibrinolytic responses in healthy subjects. Methods: Two protocols have been performed. (1) 6 healthy men (mean age= 48 ± 5 yr) performed KAATSU (160 mmHg) of both thighs for 15 minutes and then KAASTU training combined with low-intensity leg and foot aerobic exercises for ~10 minutes in hypobaric chamber, which mimics 8000 feet in airflight. (2) Another 7 men (mean age=30 ± 4 yr) performed leg press exercises (30 % 1 RM) with and without KAATSU of both thighs 24 h after bed rest. Blood samples were taken at rest, immediately after KAATSU, and exercises with or without KAATSU, and after exercise. For the investigation of blood fibrinolysis, determinations of tissue-type plasminogen activator (tPA) activity or antigen, plasminogen activator inhibitor (PAI)-1 activity or antigen, fibrin degradation product (FDP) and D-dimer were used. Prothrombin time (PT) and platelet counts were also measured. Results: (1) In hypobaric chamber, KAATSU by itself significantly increased tPA activity, while PAI-1 activity was unchanged. Furthermore, immediately after the exercise, tPA activity increased significantly. (2) During the exercises combined with KAATSU 24 h after bed rest, tPA antigen significantly increased, compared with control exercises, but PAI-1 antigen was unchanged. In both cases, KAATSU training did not induce fibrin formation as assessed by fibrin D-dimer and FDP. Conclusions: This study indicates that potentially favorable changes occur in fibrinolytic factors after KAATSU and KAATSU training in healthy subjects.

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“…Evidence to support an augmented pro-thrombotic state secondary to exercise following myocardial infarction in adults is complex with studies demonstrating activation of both coagulation and fibrinolytic systems for periods of up to 24 hours after exercise and for periods of up to 3 months after myocardial infarction. [11][12][13] Given the demographics of our study population, exercise induced platelet and coagulation activation was likely to be greater than that of the fibrinolytic system. The lack of stent thrombosis despite this effect suggests that an exercise induced pro-thrombotic state requires the presence of established major risk factors for stent thrombosis before thrombosis is precipitated.…”

Section: Discussionmentioning

confidence: 99%

Early exercise stress testing is safe after primary percutaneous coronary intervention

Kanthan

Tan

Zecchin

et al. 2012

European Heart Journal: Acute Cardiovascular Care

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Background: The optimal timing of exercise stress testing post primary percutaneous coronary intervention is uncertain with anecdotal evidence suggesting an increased risk of acute myocardial infarction and/or death if performed too early. This has translated into a delayed return to normal life activities following an acute myocardial infarction resulting in an increase in socio-economic burden. Aims: We hypothesize that early (within 7 days of primary percutaneous coronary intervention) exercise stress testing is safe. Methods: A prospective study of consecutive patients enrolled into the Cardiac Rehabilitation Program at a tertiary referral centre that underwent primary percutaneous coronary intervention, and who were able to perform a treadmill stress test were recruited. Timing of exercise stress testing was within 7 days post primary percutaneous coronary intervention and outcomes of death, acute myocardial infarction and other major adverse cardiac event were assessed 24 hours post exercise stress testing. Results: Recruited patients (n=230) aged between 29 and 78 (mean age 56 ± 10 years) with 191 being males (83%) and 39 being females (17%). While 28 patients had a positive stress test (12.2%), there were no deaths, acute myocardial infarction or any other major adverse cardiac event within 24 hours of performing the exercise stress testing. Mean METS achieved were 8.1 ± 2.3. Conclusions: Early exercise stress testing after primary percutaneous coronary intervention appears safe.

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Evaluation of Clotting and Fibrinolytic Activation after Protracted Physical Exercise

Cited by 73 publications

References 34 publications

The Effect of Acute Training and Circadian Rhythm on Blood Hemostasis in Female Athletes

The Effect of Acute Training and Circadian Rhythm on Blood Hemostasis in Female Athletes

Effects of KAATSU training on haemostasis in healthy subjects

Early exercise stress testing is safe after primary percutaneous coronary intervention

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