Evaluation of Clinical Utility of Detecting Circulating Tumor Dna Mutation Gene Locus Tp53 Rs28934571 Using Real Time PCR and Droplet Digital PCR in Egyptian Hepatocellular Carcinoma Patients
SAFEYA MAGHRABY,
AMANY IBRAHIM,
IMAN MONTASSER
et al.
Abstract:Liver cancer has been known to be the sixth cause of cancer worldwide. In Egypt, it is the fourth cause of cancer and the second -related mortality. The P53 is considered the guardian of the genome to prevent accumulation of oncogenic mutations that lead to malignant tumor.The study compared the circulating tumor DNA (ctDNA) by targeting hotspot mutation gene locus TP53 rs28934571 (c.747G>T) in normal persons, chronic liver disease patients, and in hepatocellular carcinoma (HCC) ones to evaluate its diagnostic… Show more
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