Evaluation of Clinical, Serum Biochemical and Oxidant-antioxidant Profiles in Dairy Cows with Left Abomasal Displacement

Aly, Mahmoud; Saleh, Nahed; Allam, Tamer; Keshta, Hany G.

doi:10.3923/ajava.2016.242.247

Cited by 9 publications

(17 citation statements)

References 16 publications

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“…and antioxidant species (superoxide dismutase, glutathione peroxidase, vitamin E, selenium, etc.) separately [18,19,21] or total antioxidant status [32,33]. Contrary to Durgut et al [23], significantly different d-ROMs and BAP levels were found in cows with LDA and healthy controls in our study.…”

Section: Discussioncontrasting

confidence: 91%

“…The results showed a significant elevation of d-ROMs and OSi and a significant reduction of BAP in LDA cows, confirming that LDA is linked to shifts in oxidative status [18,19,20,23].…”

Section: Discussionmentioning

confidence: 63%

“…Hasanpour et al [18] used other methods rather than the ones used in the current work and concluded that the antioxidant status in cows with DA was lower than that of healthy controls, similarly to the findings of our study. Aly et al [19] observed a significant elevation in the serum levels of H 2 O 2 , nitric oxide and malondialdehyde, and a significant reduction in serum catalase and glutathione reductase activities in LDA cows, confirming the induced imbalance in oxidative status linked to LDA. Unfortunately, the fact that most of the reported investigations used different analytical techniques makes it difficult to compare the data.…”

Section: Discussionmentioning

confidence: 96%

“…A few studies have evaluated the relationship between LDA and oxidative status, mostly through the determination of single parameters of oxidation and the determination of antioxidant status separately, with contrasting results [18,19,20]. Hasanpour et al [18], Mamak et al [21] and Aly et al [19] found significant elevation in oxidation parameters, accompanied with a decrease in the antioxidant capacity in cows with LDA. Maden et al [22] and Durgut et al [23] found no significant difference in oxidants and antioxidants between healthy and LDA-affected cows.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Oxidative Stress in Dairy Cows with Left Displacement of Abomasum

Fiore

Spissu

Sechi

et al. 2019

Animals

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Simple SummaryThe present study evaluated oxidative and antioxidant status in dairy cows with Left Displacement of the Abomasum (LDA), an economically important postpartum disease in cattle. The oxidant capacity of plasma measured with a test fo reactive oxygen metabolites, the d-ROMs test, was significantly higher and the plasma biological antioxidant potential (BAP), measured with the BAP test was lower in the LDA group compared with the control group. Oxidative status was assessed using an arbitrary index obtained from the ratio between d-ROMs and BAP and the results showed that cows with LDA experience an imbalance between oxidants and antioxidants.AbstractLeft Displacement of the Abomasum (LDA) is a condition that occurs in high-producing postpartum dairy cows and it causes economic losses. Studies performed in the last decade indicate that adult dairy cows experience oxidative stress. Increasing interest in the role of oxidative status in ruminant medicine has emphasized the need to develop reliable methods to assess it. A few studies have evaluated the relationship between LDA and oxidative status, mostly through the determination of single parameters of oxidation and the determination of antioxidant status separately, with contrasting results. The aim of this study was to assess the oxidative status by the measurement of Reactive Oxygen Metabolites with d-ROMs and Biological Antioxidant Potential BAP and the calculation of the Oxidative Status index in 74 multiparous dairy cows with LDA. Each case was matched with a control herdmate. The amount of free oxygen radicals in plasma samples was determined using the d-ROMs test, the concentration of antioxidants was measured using the BAP test and the Oxidative Status index was also calculated. The concentration of d-ROMs was significantly higher in the study group compared to the control group (179 ± 37.7 U CARR and 158 ± 23.0 U CARR, respectively), while the concentration of BAP was significantly lower in the study group than in the control group (2156 ± 98.1 µmol/L vs. 2558 ± 108.5 µmol/L). The Oxidative Status index value was significantly higher in cows with LDA than in healthy cows (8.3 ± 1.51 vs. 6.2 ± 0.76). The results of this study indicated that an inbalance between oxidants and antioxidants occurred in cattle with LDA.

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Section: Discussioncontrasting

confidence: 91%

“…The results showed a significant elevation of d-ROMs and OSi and a significant reduction of BAP in LDA cows, confirming that LDA is linked to shifts in oxidative status [18,19,20,23].…”

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Evaluation of Oxidative Stress in Dairy Cows with Left Displacement of Abomasum

Fiore

Spissu

Sechi

et al. 2019

Animals

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“…Although there is paucity of data in the recent literature that indicate pancreatic damage associated with LDA in cows, severe histopathological pancreatic lesions including fatty pancreas and pancreatitis were found in dairy cows with abdominal fat necrosis and obesity (Tani et al 2017). Only serum amylase has previously been studied in cows affected with LDA (Aly et al 2016). While in this study, there were no changes in serum amylase concentrations, Aly et al (2016) reported a significant increase in the activity of this enzyme in dairy cows affected with LDA (Aly et al 2016).…”

Section: Discussioncontrasting

confidence: 58%

Alterations of pancreatic functions and lipid profiles in dairy cows with left displacement of the abomasum

Ismail¹,

Am²,

Al-Rawashdeh³

et al. 2019

Vet. Med. - Czech

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The objectives of this study were to determine the serum activities of the pancreatic enzymes amylase, lipase, trypsinogen 1 and trypsinogen 2, serum concentrations of total cholesterol, high density lipoprotein, low-density lipoprotein and triglycerides and serum inflammatory indicators, namely C-reactive protein and procalcitonin, in Holstein-Friesian dairy cows with left displacement of the abomasum (LDA). A total of 60 cows (30 LDA-affected and 30 healthy) were included in the study. Laboratory analyses were performed using commercially available ELISA kits and chemical reagents according to the manufacturers’ recommendations. There was a significant increase (P ≤ 0.05) in the activities of lipase, trypsinogen 1 and trypsinogen 2 in LDA-affected cows compared to healthy cows. Amylase concentrations, however, remained unchanged. The serum concentrations of total cholesterol and high-density lipoprotein were significantly (P ≤ 0.05) increased in LDA-affected cows while the concentrations of low-density lipoprotein and triglycerides were significantly (P ≤ 0.05) decreased compared to healthy cows. Procalcitonin and C-reactive protein concentrations were significantly (P ≤ 0.05) increased in LDA-affected cows compared to healthy cows. This study indicates that displacement of the abomasum may be associated with significant pathological effects in the pancreas that may affect cows in the post-operative period.

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