Evaluation of Clinical Features of Patients Diagnosed with MIS-C

Özel, Abdulrahman; Erol, Meltem; Onan, Sertaç Hanedan; Gayret, Özlem Bostan; Barlas, Ülkem Koçoğlu; Mandel, Selen; Tosun, Volkan

doi:10.4274/bmb.galenos.2021.05.064

Cited by 1 publication

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionsupporting

confidence: 88%

“…Seven (28%) of these patients had a history of confirmed COVID-19, while all the others had a history of contact with COVID-19. The mean time from exposure to COVID-19 infection to symptom onset was 4.5 weeks, comparable to the study of Ozel et al 19 In the study by Alkan et al 11 with 36 MIS-C patients from Turkey, fever (100%), mucocutaneous (69.4%) and gastrointestinal symptoms (66.6%), neurological findings (38.8%), and cardiovascular involvement (83.3%) were reported. Similar results were found in the study by Dufort et al with fever (100%), gastrointestinal manifestations (80%), and rashes (60%) as the most common clinical findings in 95 patients with confirmed MIS-C. 4 In our study, similar to available literature, clinical findings included fever (100%), mucocutaneous (64%) and gastrointestinal symptoms (64%), neurological findings (16%), and cardiovascular involvement (68%).…”

Section: Discussionsupporting

confidence: 81%

“…In other studies, rates of PICU care have varied widely between 25 and 80%. 4 16 19 25 One (4%) patient included in our study died; low mortality rates have been reported in other studies. 26 27…”

Section: Discussionsupporting

confidence: 48%

“…In other studies, rates of PICU care have varied widely between 25 and 80%. 4,16,19,25 One (4%) patient included in our study died; low mortality rates have been reported in other studies. 26,27 Cardiac involvement is a common and serious condition in pediatric MIS-C. 7 Although the mechanisms of myocardial involvement are unclear, it is thought to be caused due to the inflammatory response triggering myocyte injury and viral invasion of myocytes.…”

Section: Discussionsupporting

confidence: 47%

“…16 Ozel et al reported that all patients diagnosed with MIS-C tested positive for anti-SARS-CoV-2 IgG and that time from exposure to COVID-19 to symptom onset was 4.9 weeks. 19 Although seropositivity is unnecessary for MIS-C diagnosis, it can further support the diagnosis. All patients in our study had anti-SARS-CoV-2 IgG antibodies, whereas only two patients were RT-PCR-positive.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Multisystem Inflammatory Syndrome in Children (MIS-C) with COVID-19: A Single-Center Experience

Köle

Yükselmiş

Genç

et al. 2022

J Pediatr Infect Dis

View full text Add to dashboard Cite

Objective Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory syndrome associated with multiorgan damage that occurs following coronavirus disease 2019 (COVID-19). Research on clinical and laboratory findings, and imaging studies, aiming to predict the progression to severe disease state is limited. This study recruited patients with MIS-C who presented with mild or severe symptoms from a single center in Turkey and evaluated factors related to their symptoms. Methods This retrospective study included 25 pediatric patients with mild and severe presentations of MIS-C. We explored the differences in demographic and clinical data on clinical severity to understand their possible diagnostic and prognostic values. Results Patients with MIS-C had cardiovascular symptoms (68%), gastrointestinal symptoms (64%), dermatologic/mucocutaneous findings (64%), lung involvement (36%), and neurological symptoms (16.0%). About 45.1% of patients with MIS-C had manifestations that overlapped with Kawasaki disease. Eleven patients (44%) were admitted to the intensive care unit, and one (4%) patient died. Grouping based on clinical severity did not differ statistically in terms of gender, age, height, weight, body mass index, and duration of hospital stay. Procalcitonin and ferritin levels correlated with disease severity. The receiver operating characteristic curve for D-dimer gave the highest value of area under the curve, among other biomarkers. The cutoff value for D-dimer was determined as more than 6780. Conclusions Although COVID-19 is usually mild in children, some can be severely affected, and clinical severity in MIS-C can differ from mild to severe multisystem involvement. This study shows that procalcitonin, ferritin, and D-dimer levels may give us information about disease severity.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 81%