Evaluation of clinical and endoscopic toxicity after external beam radiotherapy and endorectal brachytherapy in elderly patients with rectal cancer treated in the HERBERT study

Rijkmans, E.C.; Triest, Baukelien van; Nout, Remi A.; Kerkhof, Ellen M.; Buijsen, Jeroen; Rozema, Tom; Franssen, J.H.; Velema, Laura A.; Laman, M.S.; Cats, Annemieke; Marijnen, Corrie A.M.

doi:10.1016/j.radonc.2017.12.023

Cited by 21 publications

(16 citation statements)

References 46 publications

(27 reference statements)

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“…Therefore, in addition to the oncological outcome, this study provides detailed quality of life and functional outcome. Similar to other studies reporting on functional outcome after external-beam radiotherapy and intracavity irradiation, a decrease in bowel function and quality of life was observed in the first period after treatment [22,33]. The present study shows that this was generally restored to baseline levels at six months.…”

Section: Discussionsupporting

confidence: 91%

“…Although functional outcome following high-dose-rate brachytherapy is reported in detail [22], most studies on contact X-ray brachytherapy provide little detail on functional outcome. Especially in older or inoperable patients, who are not necessarily treated with curative intent, the functional outcome and quality of life are highly important.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Contact x-ray brachytherapy for older or inoperable rectal cancer patients: short-term oncological and functional follow-up.

Custers

Geubels

Huibregtse

et al. 2022

European Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Contact x-ray brachytherapy for older or inoperable rectal cancer patients: short-term oncological and functional follow-up.

Custers

Geubels

Huibregtse

et al. 2022

European Journal of Surgical Oncology

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“…Patients received 13 fractions of 3 Gy EBRT followed by three weekly HDREBT applications of 5, 6, 7 or 8 Gy per fraction six weeks after EBRT. Details of the study design and methods have been described previously [6,8].…”

Section: Methodsmentioning

confidence: 99%

Predictive factors for response and toxicity after brachytherapy for rectal cancer; results from the HERBERT study

Rijkmans

Marijnen

Triest

et al. 2019

Radiotherapy and Oncology

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Radiotherapy and Oncologyj o u r n a l h o m e p a g e : w w w . t h e g r e e n j o u r n a l . c o m 0.0-3.2 Volume cumulative dose § Volume EQD2 60 Gy a/b = 3 (cc) 102.9 26.2-203.1 Volume EQD2 60 Gy a/b = 10 (cc) 61.9 16.9-123.6 Volume EQD2 75 Gy a/b = 3 (cc) 50.0 13.7-104.4 Volume EQD2 75 Gy a/b = 10 (cc) 33.0 9.0-70.3 Abbreviations: HDREBT, High dose rate endorectal brachytherapy. EQD2, equivalent dose in 2 Gy fractions. Gy/#, Gy per brachytherapy fraction. * Based on delineation on diagnostic MRI. y Based on diagnostic endoscopy and MRI. à Based on HDREBT planning-CT. § Volume derived from isodose lines (including applicator) corresponding to a cumulative dose of 60 and 75 Gy.

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“…With a median follow-up of 30 months, 60% of the cohort achieved cCR, with a 2-year freedom from local progression in Unintended consequences of treating early rectal cancers with chemoradiotherapy Review 55% and regrowth in only 30%. Toxicities were high with late grade 2 and ≥3 proctitis occurring in 48 and 40%, respectively [109].…”

Section: Chronic Painmentioning

confidence: 99%

Unintended Consequences of Treating Early Rectal Cancers for Complete Clinical Response with Chemoradiotherapy

2020

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The aim was to examine the current trend in rectal cancer, which is to extend ’watch-and-wait’ to earlier-stage tumors, not normally treated with chemoradiotherapy, to define the up-side and down-side regarding quality of life (QOL) and anorectal/sexual/urinary function from this approach. We reviewed the literature regarding a ‘watch-and-wait’ strategy after neoadjuvant chemoradiotherapy. The primary outcome measure was complete clinical response. Secondary measures included colostomy rate, functional outcomes and QOL. There is a trend to use chemoradiotherapy in earlier tumors using dose-escalation of radiation and/or additional chemotherapy, resulting in high rates of complete clinical response, which may impact adversely on QOL if radical surgery is subsequently required. Focusing on organ-preservation as the primary goal of treatment rather than overall functional outcomes and QOL for the whole population, may not provide patients with sufficient information for optimal decision-making.

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Evaluation of clinical and endoscopic toxicity after external beam radiotherapy and endorectal brachytherapy in elderly patients with rectal cancer treated in the HERBERT study

Abstract: Acknowledgments: We kindly thank Karen Neelis and Yvette van der Linden for the inclusion of patients and Mirjam Laman and Inge van Ruiten for their contribution in the brachytherapy treatment.

Cited by 21 publications

References 46 publications

Contact x-ray brachytherapy for older or inoperable rectal cancer patients: short-term oncological and functional follow-up.

Contact x-ray brachytherapy for older or inoperable rectal cancer patients: short-term oncological and functional follow-up.

Predictive factors for response and toxicity after brachytherapy for rectal cancer; results from the HERBERT study

Unintended Consequences of Treating Early Rectal Cancers for Complete Clinical Response with Chemoradiotherapy

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