Evaluation of Circulating Cardiovascular Biomarker Levels for Early Detection of Congenital Heart Disease in Newborns in Sweden

Clausen, Henning; Norén, Elisabeth; Valtonen, Salla; Koivu, Aki; Sairanen, Mikko; Liuba, Petru

doi:10.1001/jamanetworkopen.2020.27561

Cited by 6 publications

(4 citation statements)

References 60 publications

(122 reference statements)

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“…In this pilot study, we demonstrated the feasibility of using targeted metabolomics to identify biomarkers for cardiometabolic health among mothers with a CHD-affected pregnancy. Since CHD is a rare condition with various subtypes, it is challenging to obtain a large patient base in a single biomarker study [10,79,80]. Nevertheless, our assessment adds to a growing body of literature indicating that mothers of children with birth defects may be at risk for adverse health conditions.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Signatures and Subsequent Maternal Health among Mothers with a Congenital Heart Defect-Affected Pregnancy

et al. 2022

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Congenital heart defects (CHDs) are the most prevalent and serious of all birth defects in the United States. However, little is known about the impact of CHD-affected pregnancies on subsequent maternal health. Thus, there is a need to characterize the metabolic alterations associated with CHD-affected pregnancies. Fifty-six plasma samples were identified from post-partum women who participated in the National Birth Defects Prevention Study between 1997 and 2011 and had (1) unaffected control offspring (n = 18), (2) offspring with tetralogy of Fallot (ToF, n = 22), or (3) hypoplastic left heart syndrome (HLHS, n = 16) in this pilot study. Absolute concentrations of 408 metabolites using the AbsoluteIDQ® p400 HR Kit (Biocrates) were evaluated among case and control mothers. Twenty-six samples were randomly selected from above as technical repeats. Analysis of covariance (ANCOVA) and logistic regression models were used to identify significant metabolites after controlling for the maternal age at delivery and body mass index. The receiver operating characteristic (ROC) curve and area-under-the-curve (AUC) are reported to evaluate the performance of significant metabolites. Overall, there were nine significant metabolites (p < 0.05) identified in HLHS case mothers and 30 significant metabolites in ToF case mothers. Statistically significant metabolites were further evaluated using ROC curve analyses with PC (34:1), two sphingolipids SM (31:1), SM (42:2), and PC-O (40:4) elevated in HLHS cases; while LPC (18:2), two triglycerides: TG (44:1), TG (46:2), and LPC (20:3) decreased in ToF; and cholesterol esters CE (22:6) were elevated among ToF case mothers. The metabolites identified in the study may have profound structural and functional implications involved in cellular signaling and suggest the need for postpartum dietary supplementation among women who gave birth to CHD offspring.

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Section: Discussionmentioning

confidence: 99%

Metabolomics Signatures and Subsequent Maternal Health among Mothers with a Congenital Heart Defect-Affected Pregnancy

et al. 2022

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“…La detección posnatal temprana de cardiopatía congénita se puede mejorar a través de protocolos de examen clínico estandarizados, pero la evaluación de recién nacidos con cardiopatía congénita requiere experiencia clínica debido a la transición de la circulación fetal a la posnatal en los recién nacidos. En este contexto, algunos recién nacidos con hipoxemia, incluso menor debido a retrasos en la adaptación de la circulación fetal o aquellos con enfermedad pulmonar primaria, inevitablemente tendrán resultados de detección positivos, entonces la evaluación neonatal inmediata y la evaluación ecocardiográfica subsiguiente serán primordiales 65 .…”

Section: S(1) 15unclassified

Consenso formal basado en la evidencia y opinión de expertos en inmunoprofilaxis con palivizumab en pacientes con cardiopatía congénita

2024

RCCAR

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“…Congenital heart disease (CHD) is the most common congenital defect in neonates,with a birth prevalence of approximately 8 per 1,000 worldwide [ 1 , 2 ]. CHD refers to children aged 0–3 who have anatomical changes or insufficiency in the development of heart and large blood vessels during embryonic development [ 1 , 3 , 4 ]. Infants with CHD often have more nutritional difficulties, including [ 5 ] malabsorption, decreased energy intake or increased energy damand caused by infections and/or increased metabolism [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…CHD refers to children aged 0–3 who have anatomical changes or insufficiency in the development of heart and large blood vessels during embryonic development [ 1 , 3 , 4 ]. Infants with CHD often have more nutritional difficulties, including [ 5 ] malabsorption, decreased energy intake or increased energy damand caused by infections and/or increased metabolism [ 4 ]. So the proportion of infants with CHD who suffer from malnutrition is higher than normal infants [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Reliability and validity of the FFQ and feeding index for 7-to 24-month-old children after congenital heart disease surgery

Lei

Liu

et al. 2022

BMC Pediatr

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Background Congenital heart disease (CHD) is the most common congenital defect in neonates. Infants with CHD often have more nutritional difficulties, but currently, there is no unified Food Frequency Questionnaire (FFQ) for infants and young children aged 7–24 months in China. Therefore, we designed this study to assess the reliability and validity of the FFQ and feeding index for 7-to 24-month-old children after congenital heart disease surgery. Methods From July to October 2018, infants and young children aged 7–24 months after congenital heart disease surgery in Guangzhou were selected. Participants were categorized into two groups, in the first group (n = 95), the FFQ was completed twice at intervals of 7–10 days to assess reproducibility. In the second group (n = 98), participants accomplished both the FFQ and the 24-h diet records from 3 consecutive days to assess validity. The score of the Infant and Child Feeding Index (ICFI) and its qualified rate were caculated. Intraclass correlation coefficients (ICC) and Spearman correlation coefficient (SCC) were calculated for reliability and validity, respectively. Results The average intraclass correlation coefficients and spearman correlation coefficient of the FFQ were 0.536 and 0.318, all with statistical significance except the frequency of meat added. The ICFI of the first group was 8.61 (± 3.20), the qualified rate was 0.06% (6/95). The intraclass correlation coefficients of the ICFI ranged from 0.374 to 0.958; and the spearman correlation of the ICFI was -0.066 to -0.834. Conclusions The FFQ possesses satisfactory reliability and moderate validity. The reliability of the ICFI is acceptable, but the validity results are quite different, indicating that the questionnaire is limited in the evaluation of the ICFI.

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Evaluation of Circulating Cardiovascular Biomarker Levels for Early Detection of Congenital Heart Disease in Newborns in Sweden

Abstract: This diagnostic study assesses the use of dried blood samples to detect prohormone brain-type natriuretic peptide for diagnosis of congenital heart disease in neonates in Sweden.

Cited by 6 publications

References 60 publications

Metabolomics Signatures and Subsequent Maternal Health among Mothers with a Congenital Heart Defect-Affected Pregnancy

Metabolomics Signatures and Subsequent Maternal Health among Mothers with a Congenital Heart Defect-Affected Pregnancy

Consenso formal basado en la evidencia y opinión de expertos en inmunoprofilaxis con palivizumab en pacientes con cardiopatía congénita

Reliability and validity of the FFQ and feeding index for 7-to 24-month-old children after congenital heart disease surgery

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