Evaluation of cinnamaldehyde and cinnamic acid derivatives in microbial growth control

Malheiro, Joana; Maillard, Jean‐Yves; Borges, Fernanda; Simões, Manuel

doi:10.1016/j.ibiod.2018.06.003

Cited by 39 publications

(41 citation statements)

References 64 publications

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“…Plant extracts are in the spotlight as a promising solution because they consist of many bioactive compounds and pharmacokinetic synergists, which can increase the pharmaceutical value of drugs [73]. Trans-cinnamic acid (TCA) is one of the active constituents in cinnamon bark and has antimicrobial activity [84]. Many groups investigated biocidal properties of cinnamon bark crude extract (Cinn) [64,65,85].…”

Section: Discussionmentioning

confidence: 99%

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“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone-iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc-and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.Pharmaceutics 2020, 12, 361 2 of 36 20,000 related deaths in the United States in 2017 only and remains to be one of the important infection-associated mortality reasons [11,12]. The formation of biofilms on biotic and abiotic surfaces [13] paved the way for biofilm antibiotic tolerance as another major health threat [14,15]. This additional problem hampers the treatment of infections, most often gives rise to chronic infections, in the worst case to therapeutic failure, severe morbidity, and mortality [4]. More than 80% of microbial infections are caused by microbial biofilm formation and pose a severe health risk because treatment with antibiotics remains ineffective [16]. The incidence of chronic wound infections is increasing globally to alarming levels [17]. Chronic wounds are marked by high bacterial colonization and infection rates, which can be treated only by novel therapeutic approaches other than the use of conventional antibiotics [18,19]. Chronic wound tissues can contain microbiomes of complex communities with coexisting fungal and bacterial colonies of different strains within biofilms [20]. According to this inter-kingdom model, fungi like Candida albicans can offer structures for other bacteria (S. aureus, P. aeruginosa, Streptococcus spp., E. faecalis, E. coli, and Acinetobacter baumannii etc.) to attach, form intricate biofilms, and increase the resistance against any ...

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Section: Discussionmentioning

confidence: 99%

“…Another antimicrobial action of trans-cinnamic acid is due to its phenolic ring, which interacts with the proteins in the cytoplasmic membranes and causes leakage of cell constituents [70]. TCA can be used as a potential food preservative to inhibit the bacterial growth [70,84].…”

Section: Discussionmentioning

confidence: 99%

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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“…Atmaram Upare et al synthesized cinnamic acid derivatives (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) (Figure 4) in which the carboxyl group was replaced with bioisostere 1,2,4-oxadiazole followed by substituting the phenyl ring of the cinnamic acid resulting in a series of novel styryl oxadiazoles. The compounds were tested in vitro at day 8 for their anti-tubercular activity against H37Ra strain of Mycobacterium tuberculosis (Table 2).…”

Section: Lunatus Aniger P Ostreatusmentioning

confidence: 99%

“…The phytochemicals and derivatives were also compared with the commonly used biocides such as sodium hypochlorite, triclosan, hydrogen peroxide, etc. Compound 27 appeared to be the most potent on all the three bacteria species, with better efficacy than sodium hypochlorite (Table 3) [16].…”

Section: Compounds %Fungal Growth In 05 Mmol/l Of Inhibitormentioning

confidence: 99%

“…Drug resistance and the absence of curative therapies with low adverse side effect profiles to control cancer, microbial growth, neurological disorders etc. has led to research on the development of therapeutic compounds based on cinnamic acid [16]. Due to the biological efficacy of derivatives of cinnamic acid, this review will report different recently synthesized derivatives of cinnamic acid and their biological activity in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Cinnamic Acid Derivatives and Their Biological Efficacy

Ruwizhi

Aderibigbe

2020

IJMS

206

100

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological efficacy of the synthesized cinnamic acid derivatives. Some of the derivatives have been reported to be more effective when compared to the standard drugs used to treat chronic or infectious diseases in vitro, thus making them very promising therapeutic agents. Compound 20 displayed potent anti-TB activity, compound 27 exhibited significant antibacterial activity on S. aureus strain of bacteria and compounds with potent antimalarial activity are 35a, 35g, 35i, 36i, and 36b. Furthermore, compounds 43d, 44o, 55g–55p, 59e, 59g displayed potent anticancer activity and compounds 86f–h were active against both hAChE and hBuChE. This review will expound on the recent advances on cinnamic acid derivatives and their biological efficacy.

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Green cinnamaldehyde and thymol modified zinc oxide with double synergistic antibacterial effects in polypropylene

Shi

Shen

Yang

et al. 2021

J of Applied Polymer Sci

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The green cinnamaldehyde (CA) and thymol (THY) separately or successively modified O-ZnO (O-ZnO-CA, O-ZnO-THY, and O-ZnO-CA-THY) were prepared after (3-aminopropyl) triethoxysilane (KH550) was grafted to the surface of ZnO (O-ZnO) and characterized by FTIR, TGA, and SEM. Polypropylene composites (PP/O-ZnO-CA, PP/O-ZnO-THY, and PP/O-ZnO-CA-THY) were prepared by melting the modified O-ZnO and PP. The antibacterial tests showed that the antibacterial rate of PP/O-ZnO-CA and PP/O-ZnO-THY against S. aureus and E. coli was obviously enhanced. It indicated an excellent synergetic antibacterial effect of O-ZnO and the little CA or THY grafted on the surface of O-ZnO. The antibacterial effect of O-ZnO-CA and O-ZnO-THY was related to the hydrophobic and hydrophilic groups contained in CA and THY. Importantly, CA and THY in O-ZnO-CA-THY exhibited another excellent synergetic antibacterial effect against both S. aureus and E. coli. The antibacterial rate of three PP composites containing 4 phr O-ZnO-CA-THY against S. aureus and E. coli reached 95% and 90%, respectively. The mechanism was regarded as that CA and THY grafted onto the same O-ZnO improved the contact probability between antibacterial agents and bacteria. Moreover, O-ZnO-CA, O-ZnO-THY, and O-ZnO-CA-THY had excellent migration resistance in the PP matrix.

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Evaluation of cinnamaldehyde and cinnamic acid derivatives in microbial growth control

Cited by 39 publications

References 64 publications

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

Cinnamic Acid Derivatives and Their Biological Efficacy

Green cinnamaldehyde and thymol modified zinc oxide with double synergistic antibacterial effects in polypropylene

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