Evaluation of cilazapril release profiles with the use of lignin-based spherical particles

Stanisz, Małgorzata; Kłapiszewski, Łukasz; Moszyński, Dariusz; Stanisz, Beata; Jesionowski, Teofil

doi:10.1016/j.jddst.2022.103636

Cited by 4 publications

(4 citation statements)

References 56 publications

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“…In the case of HAp, it could tend to agglomerate mostly due to hydrogen bonds, whereas in the case of Zn‐HAp carrier covered with the drug, these bonds are not so strong because the molecule is surrounded by organic molecules not prone to strong agglomeration. The zeta potential value for the material Zn‐HAp‐6MP is close to −30 mV, a value indicating that the material does not agglomerate at neutral pH and is able to form stable suspensions due to the electrostatic repulsion 28,29 . The zeta potential increases for both materials as the pH decreases.…”

Section: Resultsmentioning

confidence: 82%

“…The zeta potential value for the material Zn-HAp-6MP is close to À30 mV, a value indicating that the material does not agglomerate at neutral pH and is able to form stable suspensions due to the electrostatic repulsion. 28,29 The zeta potential increases for both materials as the pH decreases. This means that both of these materials are more likely to agglomerate in acidic environment.…”

Section: Uv-vis Spectroscopymentioning

confidence: 99%

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Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine

Jakubowski,

Majchrzycki,

Zarkov

et al. 2024

J Biomed Mater Res

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Abstract6‐Mercaptopurine (6MP) is commonly used in the treatment of acute lymphoblastic leukemia as an important agent in maintenance therapy. Despite its therapeutic benefits, 6MP has some limitations during therapy. Taking into account the disadvantages during 6MP therapy, there is a great need to create an appropriate delivery system for this drug. 6MP contains in its structure nitrogen and sulfur atoms capable of forming coordination compounds with metal ions, for example zinc. Therefore, in this work, we prepared biocompatible hydroxyapatite (HAp) doped with zinc ions, and used it as a carrier for 6MP. Doped HAp has not been used as a carrier for this drug before. The work proved that the prepared carrier‐drug system has a particle size of about 130 nm, which indicates its potential for intravenous delivery. In addition, in an acidic environment (imitating cancer cells), the carrier agglomerates allow targeted release of the drug. The drug is evenly distributed, which indicates that the doses released from it will always be comparable. The release of the drug in a neutral environment is long‐lasting in controlled doses, whereas in an acidic environment it is immediate. The obtained results indicate the high potential of the material in both slow‐release and cancer‐targeted release of 6MP.

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Section: Resultsmentioning

confidence: 82%

Section: Uv-vis Spectroscopymentioning

confidence: 99%

Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine

Jakubowski,

Majchrzycki,

Zarkov

et al. 2024

J Biomed Mater Res

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“…The drug layer does not have adhesive properties like the polydopamine layer. The zeta potential value for the material mSiO2-PDA-Zn-MERC is close to −30 mV, a value indicating that the material does not agglomerate at a neutral pH [ 51 , 52 ]. The results of the particle size distribution may seem illogical, as the samples after the sorption of the drug reduce in size.…”

Section: Resultsmentioning

confidence: 99%

Mesoporous Silica Modified with Polydopamine and Zinc Ions as a Potential Carrier in the Controlled Release of Mercaptopurine

Sandomierski,

Chojnacka,

Długosz

et al. 2023

Materials

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Mercaptopurine is one of the drugs used in the treatment of acute lymphoblastic leukemia. A problem with mercaptopurine therapy is its low bioavailability. This problem can be solved by preparing the carrier that releases the drug in lower doses but over a longer period of time. In this work, polydopamine-modified mesoporous silica with adsorbed zinc ions was used as a drug carrier. SEM images confirm the synthesis of spherical carrier particles. The particle size is close to 200 nm, allowing for its use in intravenous delivery. The zeta potential values for the drug carrier indicate that it is not prone to agglomeration. The effectiveness of drug sorption is indicated by a decrease in the zeta potential and new bands in the FT-IR spectra. The drug was released from the carrier for 15 h, so all of the drug can be released during circulation in the bloodstream. The release of the drug from the carrier was sustained, and no ‘burst release’ was observed. The material also released small amounts of zinc, which are important in the treatment of the disease because these ions can prevent some of the adverse effects of chemotherapy. The results obtained are promising and have great application potential.

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“…Some groups have investigated the use of lignin as an emulsion stabilizer, which is a feld that encompasses a large portion of the chemical industry. Research has found that not only lignin-based surfactants but also lignin nanoparticles (LNPs) perform well as emulsion stabilizers and have already been used as potential candidates for more environment-friendly stabilizers [11,12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Lignin Nanoparticles and Their Application in the Stabilization of Water-in-Water Pickering Emulsions: A New Technology for Valorization of Lignin from Sugarcane Bagasse

Pedro,

Feitosa,

Costa Filho

et al. 2024

International Journal of Chemical Engineering

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Water-in-water (w/w) emulsions can mimic biological environments, and their stability is ensured by adding nanoparticles capable of adsorbing at liquid-liquid interfaces. To enhance the properties of w/w emulsions, there is a search for new sources of nanoparticles that are attractive for the food and biomedical fields. Thus, the present study investigated the use of sugarcane bagasse lignin (a cheap, nontoxic, and biodegradable polymer) as a source of nanoparticles for Pickering emulsions with maltodextrin (MD) and polyethylene glycol 6000 (PEG 6000). The nanoparticles were prepared from alkaline lignin (ALNP) and oxidized alkaline lignin (OLNP), and their application was performed using different dosages in the w/w systems (0%, 0.1%, 0.3%, 0.5%, and 1%, wt/wt). The nanoparticles presented different sizes, with OLNPs (327.8 nm) being smaller than ALNPs (689.8 nm). The systems with OLNPs showed better emulsification indices and smaller droplet sizes than systems with ALNPs. The concentration of nanoparticles and the volume of the dispersed phase influence the stability of the studied emulsion. The most promising stabilization results were obtained at a concentration of 1% wt/wt of OLNPs with an emulsification index of up to 63%. These results, combined with the extensive availability of functional groups in lignin, make this polymer a potential candidate for advanced studies of w/w emulsions.

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Evaluation of cilazapril release profiles with the use of lignin-based spherical particles

Cited by 4 publications

References 56 publications

Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine

Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine

Mesoporous Silica Modified with Polydopamine and Zinc Ions as a Potential Carrier in the Controlled Release of Mercaptopurine

Synthesis of Lignin Nanoparticles and Their Application in the Stabilization of Water-in-Water Pickering Emulsions: A New Technology for Valorization of Lignin from Sugarcane Bagasse

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