Evaluation of Choroidal Thickness in Ankylosing Spondylitis Using Optical Coherence Tomography

Kola, Mehmet; Kalkişim, Ahmet; Karkucak, Murat; Türk, Adem; Çapkın, Erhan; Can, Ipek; Serdar, Omer Faruk; Mollamehmetoğlu, Süleyman; Ayar, Ahmet

doi:10.3109/09273948.2014.928734

Cited by 40 publications

(37 citation statements)

References 19 publications

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“…OCT has been used to evaluate choroid thickness in patients with a number of systemic autoimmune and inflammatory disorders (9)(10)(11)(12)(13) . Patients with active Vogt-Koyanagi-Harada disease have been shown to have markedly increased choroidal thickness, possibly related to inflammatory infiltration and increased exudation (9) .…”

Section: Discussionmentioning

confidence: 99%

“…Gungor et al reported patients with posterior ocular sarcoidosis in the absence of active ocular inflammation had decreased choroidal thickness compared to normal subjects during the quiescent phase of the disease (12) , however, the authors were unable to provide a satisfactory explanation for this finding. Kola et al reported increased choroidal thickness in patients with ankylosing spondylitis compared to healthy controls (13) . The authors proposed that chronic systemic inflammation may play an important role in the thickening of the choroid layer in patients with ankylosing spondylitis (13) .…”

Section: Discussionmentioning

confidence: 99%

“…Kola et al reported increased choroidal thickness in patients with ankylosing spondylitis compared to healthy controls (13) . The authors proposed that chronic systemic inflammation may play an important role in the thickening of the choroid layer in patients with ankylosing spondylitis (13) . However, found to no significant correlation between chorodial thickness and systemic inflammatory markers (13) .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a new method of SD-OCT, termed enhanced depth imaging (EDI), has been shown to be capable of visualizing the full thickness of the choroid (8) . Changes in choroidal thickness have previously been reported in a number of autoimmune and systemic inflammatory disorders (9)(10)(11)(12)(13) . To the best of our knowledge, studies using EDI-OCT to evaluate choroidal segment involvement in patients with IBD have yet to be reported.…”

Section: Introductionmentioning

confidence: 93%

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Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Önal¹,

Yüksel²,

Bayrakceken³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Gazi University Ethics Committee. Number N o 53 -26/01/2015. ABSTRACTPurpose: Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity. Methods: A total of 62 eyes of 31 patients with IBD [Crohn's disease (CD), n=10 and ulcerative colitis (UC), n=21] and 104 eyes of 52 healthy blood donors were included in this study. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. The Crohn's disease activity index (CDAI) and the modified Truelove Witts score were used to assess disease activity in CD and UC, respectively. Results: No significant differences in mean subfoveal, nasal 3000 µm, or temporal 3000 µm choroidal thickness measurements (P>0.05 for all) were observed between IBD patients and healthy controls. Age, smoking, CD site of involvement (ileal and ileocolonic involvement), CDAI, CD activity, and UC endoscopic activity index were all found to be significantly correlated with choroidal thickness by univariate analysis (P<0.05). Smoking (P<0.05) and the CD site of involvement (P<0.01) were the only independent parameters associated with increased choroidal thickness at all measurement locations. Conclusions: Choroidal thickness is not a useful marker of disease activity in patients with IBD but may be an indicator of ileal involvement in patients with CD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Önal¹,

Yüksel²,

Bayrakceken³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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“…1 In our study in question we examined choroidal thickness values in cases of ankylosing spondylitis. 2 That study showed that the choroid can be affected in ankylosing spondylitis.…”

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confidence: 99%

Regarding Comments by Yolcu et al. on “Evaluation of Choroidal Thickness in Ankylosing Spondylitis Using Optical Coherence Tomography”

Kola

Kalkişim

Karkucak

et al. 2015

Ocular Immunology and Inflammation

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The effect of allergic rhinitis with positive skin prick test on choroidal thickness

Yenigün

Elbay

Doğan

et al. 2017

Eur Arch Otorhinolaryngol

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Allergic rhinitis is an inflammatory disease that develops through immunoglobulin E in the rhino-ocular mucosa due to allergy. The main symptoms are runny nose, nasal congestion, sneezing and itchy nose. This study was designed to investigate the effect of allergic rhinitis on choroidal thickness. This study was planned as a case-control study. This study performed in a tertiary referral center. The study included 61 patients with allergic rhinitis and 35 healthy subjects. Patients in both groups underwent skin prick test. In allergic rhinitis patients and healthy persons; subfoveal, temporal and nasal choroidal thickness measurement was performed. The choroidal thicknesses were measured without pupil dilation using the Spectralis Optical Coherence Tomography. In the subfoveal and temporal region, choroidal tissue was followed up significantly thicker in allergic rhinitis patients statistically compared to healthy persons (p = 0.031, p = 0.049). However, no significant difference was followed up between the nasal choroidal thickness measurements statistically (p = 0.54). Runny nose (67.2%), sneeze (65.5%), stuffiness (62.2%), itching of the nose (40.9%), and nasal discharge (21.3%) complaints were observed significantly higher in the group having allergic rhinitis. The effect of allergic rhinitis on choroidal thickness were assessed and compared with the control group. Our study revealed that there was significant association between increased choroidal thickness and allergic rhinitis. Allergic sensitivity may play an important role in increased choroidal thickness.

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Evaluation of Choroidal Thickness in Ankylosing Spondylitis Using Optical Coherence Tomography

Abstract: This is the first study to evaluate effects of AS on CT. CT was high in patients with AS compared to healthy controls.

Cited by 40 publications

References 19 publications

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Regarding Comments by Yolcu et al. on “Evaluation of Choroidal Thickness in Ankylosing Spondylitis Using Optical Coherence Tomography”

The effect of allergic rhinitis with positive skin prick test on choroidal thickness

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