Evaluation of Choroidal Thickness in Children With Iron Deficiency Anemia

Şimşek, Ali; Tekin, Mehmet; Bilen, Abdurrahman; Karadağ, Ayşe Sevgi; Bucak, İbrahim Hakan; Turğut, Mehmet

doi:10.1167/iovs.15-18713

Cited by 20 publications

(13 citation statements)

References 29 publications

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“…Egzersiz, gebelik, erkek cinsiyet, sildenafil kullanımı, prediyabetik retinopati, çocukluk çağı obesitesinin koroid kalınlığını artırdığı bildirilmiştir (12)(13)(14)(15)(16)(17) . Konjestif kalp yetersizliği, karotis stenozu, sigara, kahve, ileri yaş, çocuklarda demir eksikliği anemisi, diyabetik makülar ödem ve proliferatif diyabetik retinopatinin eşlik ettiği diyabetin koroid kalınlığını azalttığı bildirilmiştir (7,(18)(19)(20)(21)(22) . Yüksek myopiye neden olan aksiyel uzunluk artışı ve yaşa bağlı koroidal atrofi koroid kalınlığını azaltan oküler nedenlerdir (23,24) .…”

Section: Discussionunclassified

Effect of diastolic heart dysfunction due to hypertrophic cardiomyopathy on choroidal thickness

Bayramoğlu¹,

Özbay²,

Sayın³

2018

İKSST

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Section: Discussionunclassified

Effect of diastolic heart dysfunction due to hypertrophic cardiomyopathy on choroidal thickness

Bayramoğlu¹,

Özbay²,

Sayın³

2018

İKSST

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“…IDA is the most frequent and treatable anemia worldwide (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). The prevalence of IDA is higher in women, especially in premenopausal women and uncommon in adults (1, 2, 14).…”

Section: Discussionmentioning

confidence: 99%

“…of hypoxia, detrimental effects can be seen in various systems of the body including ocular structures through enhancement of effects of ischemia (5). Several studies have shown the effect of iron deficiency on ocular structures, especially focused on the posterior segment of eye (6)(7)(8)(9)(10). However, a recent study evaluating the anterior segment focusing on endothelial cells showed significant changes at IDA (9).…”

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confidence: 99%

The Evaluation of Corneal and Lenticular Parameters in Iron Deficiency Anemia

Kızıltoprak¹

2021

Beyoglu Eye J

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Anemia which is defined as blood hemoglobin (Hb) or hematocrit concentration below the lower limit of the normal range is a major and widespread public health problem (1). Iron deficiency anemia (IDA) is the most common cause of anemia among children, women of childbearing age, and pregnant women worldwide (1-3).The Hb that comprises iron plays an essential role in transporting oxygen from the lungs to the other tissues. Iron also plays important additional roles in the central nervous system, including normal myelination, neurotransmitter synthesis, and neurometabolism (4). In iron deficiency, hypoxia is inevitable as the blood has no longer enough capacity to transport the oxygen to the entire body. As a consequence Objectives:The aim of this study was to investigate the effects of iron deficiency anemia on corneal and lenticular densitometry. Methods: Thirty-two patients with iron deficiency anemia and 38 healthy participants were enrolled. The Pentacam HR imaging system (Oculus Optikgeräte GmbH, Wetzlar, Germany) was used to record keratometry, corneal densitometry (12mm corneal diameter), lens densitometry measurements. Endothelial parameters were evaluated using specular microscopy. Results:The corneal densitometry values in the anterior 0-2 mm and 2-6 mm zone were significantly higher in the iron deficiency anemia group than in the control group (p=0.044 and p=0.021, respectively). There was a statistically significant difference in the mean values of the standard deviation and maximum lens densitometry measurements of the iron deficiency anemia group when compared with the control group (p=0.012 and p=0.011, respectively). There were statistically significant correlations between the anterior 2-6 mm zone corneal densitometry and ferritin, iron, and total iron binding capacity (r=-0.275, r=-0.243, r=0.240, respectively). However, ferritin, iron, and total iron binding capacity showed no significant correlation with the lens densitometry values (p>0.05 for all). Conclusion: Iron deficiency anemia had several effects on corneal and lenticular densitometry measurements. Evaluation of the corneal and lenticular changes at an ophthalmology clinic might be recommended for patients with iron deficiency anemia.

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“…We planned our study of a continuous response variable from independent control and experimental subjects with one control(s) per experimental subject. In a previous study 12 the response within each subject group was normally distributed with standard deviation 39.77. If the true difference in the experimental and control means was 30.54, we needed to study at least 28 experimental subjects and 28 control subjects to be able to reject the null hypothesis that the population means of the experimental and control groups are equal with probability (power) 0.8.…”

Section: Sample Size Calculationsmentioning

confidence: 99%

“…In recent studies, central corneal thickness (CCT) and choroidal thickness were found to be decreased in children with sickle cell anemia and iron deficiency anemia (IDA). 11 , 12 In the present study, the CCT, specular microscopic measurements, the thickness of retinal nerve fiber layer (RNFL), and the thickness of ganglion cell-inner plexiform layer (GC-IPL) were compared between the females with IDA, combined IDA and vitamin B12 anemia (B12DA), and healthy females.…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Ophthalmic Findings in Women Patients With Iron and Vitamin B12 Deficiency Anemia

Coşkun

Sevencan

2018

Trans. Vis. Sci. Tech.

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PurposeTo determine whether there are differences in the central corneal thickness (CCT), retinal nerve fiber layer (RNFL), and ganglion cell-inner plexiform layer (GC-IPL) in women with iron deficiency anemia (IDA) and vitamin B12 deficiency anemia (B12DA).MethodsThe patients were divided and evaluated in three groups as IDA (group 1), combined IDA-B12DA (group 2), and healthy females (group 3). Each group constituted 35 subjects. CCT, endothelial cell density (CD), the coefficient of variation (CV), and hexagonality (HEX) values were evaluated. Superior, nasal, inferior, and temporal retinal nerve fiber analysis were done, and mean thickness of GC-IPL complex was also evaluated.ResultsCCT was found to be less (thin CCT) in group 2 as compared to group 1 and group 3 (P = 0.016 and P = 0.013, respectively). While CD measurements did not vary significantly between the groups, CV value was found to be lower in the control group as compared to that in the other groups (P = 0.001 and P = 0.002, respectively). HEX and the thicknesses of all RNFL and GC-IPL were lower in both the anemic groups as compared to the control group (P = 0.012 and P = 0.013, respectively); however, no significant difference was determined between the anemia groups.ConclusionsIt should be noted that anemia is a common clinical picture particularly seen in women, and there may be a tendency toward corneal and retinal disorders in these patients. The present study found that presence in the patients with IDA and with combined IDA-B12DA may have influenced endothelial functions; also the patients with anemia had significantly thinner CCT than healthy controls.Translational RelevanceOptical coherence tomography and specular microscopy measurements may provide important data for early diagnosis and treatment of both corneal and retinal diseases according to the type of anemia in anemic women.

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Evaluation of Choroidal Thickness in Children With Iron Deficiency Anemia

Abstract: The patients with IDA had significantly thinner choroidal thicknesses than those of the healthy children. Choroidal thinning in childhood may be an early sign of deterioration in the ocular blood circulation, without any risk of atherosclerosis in advanced age in the patients with IDA.

Cited by 20 publications

References 29 publications

Effect of diastolic heart dysfunction due to hypertrophic cardiomyopathy on choroidal thickness

Effect of diastolic heart dysfunction due to hypertrophic cardiomyopathy on choroidal thickness

The Evaluation of Corneal and Lenticular Parameters in Iron Deficiency Anemia

The Evaluation of Ophthalmic Findings in Women Patients With Iron and Vitamin B12 Deficiency Anemia

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