Evaluation of cholinesterase and lipid profile levels in chronic pesticide exposed persons

Pothu, Usha Kiran; Thammisetty, Anil Kumar; Nelakuditi, Lakshmana Kumar

doi:10.4103/jfmpc.jfmpc_239_19

Cited by 14 publications

(9 citation statements)

References 47 publications

(47 reference statements)

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“…This was similar to our previous longitudinal study, which reported that conventional farmers had significantly higher total cholesterol, LDL, HDL, blood glucose, systolic and diastolic blood pressure, BMI, and waist circumference than organic farmers [9]. The current result was also similar to the study of Pothu et al [25] which reported that patients with decreased cholinesterase levels (higher OP exposure) had significantly higher serum cholesterol, triglycerides and LDL levels than those with normal cholinesterase levels (lower OP exposure).…”

Section: Discussionsupporting

confidence: 93%

Urinary Organophosphate Metabolites and Metabolic Biomarkers of Conventional and Organic Farmers in Thailand

Kongtip

Nankongnab

Kallayanatham

et al. 2021

Toxics

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Organophosphate (OP) pesticides are used by most farmers to remove insects and to increase productivity; however, questions remain on the long-term health impacts of their use. This study assessed the relationship between OP biomarker levels and metabolic biomarker parameters. Conventional farmers (n = 213) and organic farmers (n = 225) were recruited, interviewed, and had physical health examinations. Serum glucose and lipid profiles, triglycerides, total cholesterol, high-density lipoproteins (HDL), and low-density lipoproteins (LDL) were measured. The average age, gender, education, and self-reported agricultural work time, work in second jobs, smoking status, alcohol consumption, insecticide use at home, home location near farmlands and years of pesticide use were significantly different between the conventional and organic farmers. The urinary OP metabolite levels were also significantly different between the two groups. With an increase in urinary diethyl phosphate, dimethyl phosphate and dialkyl phosphate metabolites, the total cholesterol, LDL and HDL, were significantly increased for all farmers after controlling for age, gender, alcohol consumption, years of pesticide use, and home location near farmlands. The results are consistent with our previous studies which suggests that pesticide usage, especially organophosphates, may increase the risk of cardiovascular disease and stroke among Thai farmers.

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Section: Discussionsupporting

confidence: 93%

Urinary Organophosphate Metabolites and Metabolic Biomarkers of Conventional and Organic Farmers in Thailand

Kongtip

Nankongnab

Kallayanatham

et al. 2021

Toxics

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“…This also suggests a cytotoxic effect releasing more lipids because of membrane disruption. One of the important causes of increased total lipid concentrations also appears to be disruption of carbohydrate metabolism and imposition of cytotoxicity in blood cells (Pothu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effects of Purified Tick Saliva Toxins on Various Bio-Molecules in Blood Serum, Liver and Muscles of Albino Mice

Yadav,

Upadhyay

2024

American Journal of Animal and Veterinary Sciences

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In the present study, salivary toxins from Rhipicephalus microplus were isolated and purified on a Sepharose CL 6B 200 gel column at a constant flow rate with regular fractions of 5 mL/min. Pooled fractions were lyophilized and LD50 was then determined in albino mice. The LD50 value of the protein toxin of Rhipicephalus microplus was found 36.11 mg/kg body weight of albino mice. To determine physiological effects, a sub-lethal dose of Rhipicephalus microplus toxin and 40-80% 24 h LD50 of salivary toxin were injected into albino mice. In different biological assays, total serum protein, free amino acids, uric acid, cholesterol, pyruvic acid, total serum lipids and glucose levels were determined at different stages. In addition, the effects of toxins purified from tick saliva were observed on the rectus abdomens, gastrocnemius, muscles, atria and ventricles of albino rats and muscle glycogen. A significant increase in bimolecular activity was observed in the serum, liver and muscle of albino mice. The group injected with the saliva toxin showed an increase in serum protein content of 79.70% while the content of free amino acids, uric acid, cholesterol, pyruvic acid, total lipids and glucose all increased correspondingly. Toxins from tick saliva broke down glycogen stores in the liver, abdominal muscles, stomach muscles, atria and ventricles of albino mice. Toxins in tick saliva significantly reduced glycogen concentrations (67-82%) in the serum, liver, muscle and ventricles of albino mice. These effects were due to the presence of low molecular weight proteins that act on the membrane and interfere with muscle cell function in albino mice. These proteins could be used for drug development and target molecules for the generation of transmissionblocking vaccines or anti-tick vaccines.

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“…in India showed that there was a significant increase in serum cholesterol, triglyceride, and low-density lipoprotein (LDL)levels as well as a decrease in serum high-density lipoprotein (HDL) levels in the group of people exposed to organophosphate. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Associations between pesticide exposure with biomarkers of stroke risk factors in farmers

Setyopranoto,

Panggabean,

Dwianingsih

et al. 2024

JNRP

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The extensive use of pesticides may cause acute and chronic intoxication. Therefore, this study aimed to reveal the associations between pesticide exposure and serum markers for stroke risk factors in farmers. A cross-sectional study was conducted with farmers, who used chemical pesticides in Seloprojo Village, Ngablak District, Magelang Regency, Central Java Province, Indonesia. A questionnaire containing demographics, pesticide use, and aspects related to work was employed. Measurements of serum cholesterol, uric acid, glucose, cholinesterase, and fibrinogen levels were also conducted. Of the 106 subjects, 31 (29.2%) used organophosphates as chemical pesticides. There was a significant difference between organophosphate and nonorganophosphate groups in plasma fibrinogen levels. The organophosphate group had higher levels of fibrinogen (292.29 ± 67.56 mg/dL) than the non-organophosphate group (255.24 ± 38.90 mg/dL). Of the studied risk factors for stroke, there is a significant association between organophosphate exposure and increased plasma fibrinogen levels.

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Evaluation of cholinesterase and lipid profile levels in chronic pesticide exposed persons

Cited by 14 publications

References 47 publications

Urinary Organophosphate Metabolites and Metabolic Biomarkers of Conventional and Organic Farmers in Thailand

Urinary Organophosphate Metabolites and Metabolic Biomarkers of Conventional and Organic Farmers in Thailand

Effects of Purified Tick Saliva Toxins on Various Bio-Molecules in Blood Serum, Liver and Muscles of Albino Mice

Associations between pesticide exposure with biomarkers of stroke risk factors in farmers

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