Evaluation of chitosan/γ-poly(glutamic acid) polyelectrolyte complex for wound dressing materials

Poly-γ-glutamic acid: production, properties and applications

“…The complex presented sufficient moisture content and showed good mechanical properties, which would allow the dressing to be easily removed from the wound surface without destroying renewed tissues. Tsao et al (2011) Biological adhesive A mixture of gelatin and c-PGA aqueous solution which resulted in the formation of a hydrogel in the presence of water-soluble carbodiimide demonstrated better lung adhesion and air-leak sealing than conventional fibrin glue. Otani et al (1999) Calcium absorption Administration of c-PGA increased calcium absorption in the intestine in post-menopausal women by inhibition of the formation of an insoluble calcium complex with phosphate.…”

“…A polyelectrolyte complex (PEC) comprising chitosan as a cationic polyelectrolyte and c-PGA as an anionic polyelectrolyte was designed by Tsao et al (2011) for wound dressing. Results showed that the chitosan/c-PGA PECs exhibit adequate moisture content, with c-PGA reducing the risk of dehydration compared with regular chitosan.…”

Polyelectrolyte complex materials from chitosan and gellan gum

“…Many studies have been devoted to the preparation of wound dressing from polysaccharides based polyelectrolyte complex (PEC) techniques 95,310,[364][365][366] .…”

Novel Chitin and Chitosan Materials in Wound Dressing

“…The membranes based on chitosan/alginate could be used on highly exuding wounds and prevented the bacterial infections (Rodrigues, Sanchez, Da Costa, & Moraes, 2008). A polyelectrolyte complex (PEC), which consists of chitosan as a cationic and -poly (glutamic acid) ( -PGA) as an anionic polyelectrolyte, was developed as a wound dressing material (Tsao et al, 2010). The physical and chemical properties of the chitosan/ -PGA PECs were fully investigated.…”

“…Histological examinations revealed that, more than 50% of re-epithelialization and regeneration of the wound are achieved by dressing it with the chitosan/ -PGA PECs. On the basis of wound-healing efficacy, chitosan/ -PGA PECs can be potentially applied as a wound dressing material (Tsao et al, 2010). A membrane composed of an alginate layer and a chitosan layer with sustained antimicrobial efficacy was prepared (Dong et al, 2010).…”