Evaluation of Childhood Health Assessment Questionnaire in Juvenile Idiopathic Arthritis: A Single Center Experience From Turkey

Gümüş, Duygu; Başaran, Özge; Çakar, Nilgün; Uncu, Nermin; Acar, Banu

doi:10.5606/archrheumatol.2015.5130

Cited by 5 publications

(4 citation statements)

References 15 publications

(22 reference statements)

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“…As CHAQ‐DI is a functional ability assessment tool, a higher CHAQ‐DI in JIA patients with active disease reflects a greater functional disability than a lower CHAQ‐DI in inactive disease. This finding is in line with that of a previous study, which reported that 82 active JIA patients had a significantly greater CHAQ‐DI than JIA patients in remission (Gümüs, Başaran, Çakar, Uncu, & Acar, ). After classifying patients according to the seven JIA subtypes, polyarthritis and systemic arthritis patients were found to have a higher CHAQ‐DI than other JIA subtypes, especially during active disease.…”

Section: Discussionsupporting

confidence: 93%

“…Patients with a higher number of active joints mostly have a higher CHAQ‐DI. A previous study revealed that JIA patients with active joint involvement had a significantly higher CHAQ‐DI compared with those without active joint involvement (Gümüs et al, ). By contrast, the study of Gueddari et al () found low correlations between CHAQ‐DI and active joint count.…”

Section: Discussionmentioning

confidence: 95%

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The correlation between the Childhood Health Assessment Questionnaire and disease activity in juvenile idiopathic arthritis

Sontichai

Vilaiyuk

2018

Musculoskeletal Care

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

The correlation between the Childhood Health Assessment Questionnaire and disease activity in juvenile idiopathic arthritis

Sontichai

Vilaiyuk

2018

Musculoskeletal Care

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“…While CHAQ is not specifically designed to differentiate between JIA subtypes, the functional limitations observed by children may vary depending on the JIA subtype. 31 In a study by Sontichai et al, 32 CHAQ was evaluated during active disease in 139 JIA patients consisting of ERA (30.9%), systemic JIA (28.1%), oligoarticular JIA (16.5%), RF-negative polyarticular JIA (15.1%), RF-positive polyarticular JIA (6.5%),and undifferentiated arthritis (2.9%). Rheumatoid factor-negative polyarticular JIA patients had the highest CHAQ, followed by systemic JIA, RF-positive polyarticular JIA, and ERA, while oligoarticular JIA had the lowest CHAQ.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Biopsychosocial Characteristics of Children with Juvenile Idiopathic Arthritis According to Common Disease Subtypes

2023

Turk Arch Pediatrics

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Objective: In this study, we assessed the functional and biopsychosocial characteristics of juvenile idiopathic arthritis (JIA) patients according to disease subtypes. Materials and Methods: Child Health Assessment Questionnaire (CHAQ), Juvenile Arthritis Disease Activity Score-71 (JADAS-71), and Juvenile Arthritis Biopsychosocial Questionnaire (JAB-Q) scales were administered to 304 JIA patients, and the subscale of JAB-Q was administered to their families. Results: The median age of JIA patients at diagnosis was 7.9 (5.5-13) years (female/male = 1.3). Most patients were under treatment (68.7%) and had inactive disease (69.3%). While there was no significant difference between JADAS-71 scores according to the JIA subtypes, total CHAQ scores in polyarticular JIA patients were higher than in systemic JIA patients ( P = .005). Enthesitis-related arthritis (ERA) patients had higher JAB-Q fatigue total scores compared to systemic JJIA patients ( P = .001). Juvenile Arthritis Biopsychosocial Questionnaire—child psychosocial status scores were higher in polyarticular JIA patients than oligoarticular and systemic JIA patients ( P = .004 and P = .003, respectively), and they had higher JAB-Q child form total scores than systemic JIA patients ( P = .006). In addition, systemic JIA patients’ parents had higher JAB-Q family total scores compared to oligoarticular JIA patients’ parents ( P = .03). Conclusion: Our results suggest that polyarticular JIA patients had higher CHAQ, JAB-Q psychosocial status, and child form total scores, and the JAB-Q fatigue score was higher in ERA patients. Also, JAB-Q—parent scores were higher in systemic JIA patients’ parents. Biopsychosocial characteristics should be evaluated in both JIA patients and their parents.

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“…HRQL is a crucial outcome measure that provides insight into the well-being of children with SCD [11]. The Childhood Health Assessment Questionnaire (CHAQ) is commonly used to assess health status in children, and the updated versions showed improved validity in a variety of musculoskeletal problems [12,13].…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of monthly high-dose vitamin D3 supplementation in children and adolescents with sickle cell disease

Hanna,

Kamal,

Fawzy

et al. 2024

Eur J Pediatr

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Little is known about the impact of vitamin D supplementation on hand grip strength (HGS) and health-related quality of life (HRQoL) in children and adolescents with sickle cell disease (SCD). We aimed to evaluate the safety and efficacy of monthly high-dose vitamin D3 supplementation and its implications on bone mineral density (BMD), HGS, and HRQoL in patients with SCD and healthy controls. The study included 42 children with SCD and 42 healthy matched controls. The study participants were supplemented with high-dose monthly oral vitamin D3. Changes in the serum level of 25(OH) vitamin D3, maximum HGS, and BMD from baseline to 6 months were assessed, and the HRQoL questionnaire and Childhood Health Assessment Questionnaire (CHAQ) were used to evaluate the functional capacity. At baseline, SCD subjects had poorer growth status indicated by negative Z scores. Suboptimal BMD was detected by significantly lower Z score, and lower HGS and worse HRQL parameters were found compared to the controls (P < 0.001). Median 25(OH) vitamin D3 was significantly lower in SCD patients compared to controls (16.5 vs. 28 ng/mL, respectively (P < 0.001)). After 6 months of vitamin D supplementation, there was significant improvement in the DEXA Z-score (P < 0.001), limitation of physical health (P = 0.02), pain scores (P < 0.001), and CHAQ grades (P = 0.01) in SCD patients. A significant improvement in HGS (P < 0.001 and P = 0.005) as well as the CHAQ score (P < 0.001 and P = 0.003) was detected in the SCD group and controls, respectively. There were no reported clinical adverse events (AEs) or new concomitant medications (CMs) during the study duration, and safe levels of Ca and 25 (OH) D3 were observed at 3 and 6 months for both groups. There was a significant positive correlation between HGS and total physical score (r = 0.831, P < 0.001) and a negative correlation with CHAQ score (r = − 0.685, P < 0.001). We also detected a significant positive correlation between vitamin D levels at 6 months and HGS (r = 0.584, P < 0.001), pain score (r = 0.446, P < 0.001), and a negative correlation with CHAQ score (r = − 0.399, P < 0.001). Conclusion: Monthly oral high-dose vitamin D supplementation was safe and effective in improving vitamin D levels, HGS, and HRQoL in SCD children and healthy subjects, and BMD scores in SCD patients. Further randomized controlled trials are warranted to assess an optimal dosing strategy and to investigate the impact on clinically significant outcomes in children and adolescents with SCD and their healthy counterparts. Trial registration: ClinicalTrials.gov, identifier NCT06274203, date of registration: 23/02/2024, retrospectively registered. What is known:• Several studies have reported a high prevalence of vitamin D deficiency and suboptimal bone mineral density (BMD) in sickle cell disease (SCD) patients.• Musculoskeletal dysfunction is reported in SCD patients with a negative impact on physical activity and health-related quality of life (HRQL).• Little is known regarding the impact of vitamin D3 supplementation in children and adolescents with SCD. What is new:• We found that monthly oral high-dose vitamin D3 supplementation was safe, tolerated, and effective in improving serum vitamin D levels, HGS, BMD scores, and HRQL in SCD patients.

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Evaluation of Childhood Health Assessment Questionnaire in Juvenile Idiopathic Arthritis: A Single Center Experience From Turkey

Cited by 5 publications

References 15 publications

The correlation between the Childhood Health Assessment Questionnaire and disease activity in juvenile idiopathic arthritis

The correlation between the Childhood Health Assessment Questionnaire and disease activity in juvenile idiopathic arthritis

Comparison of Biopsychosocial Characteristics of Children with Juvenile Idiopathic Arthritis According to Common Disease Subtypes

Safety and efficacy of monthly high-dose vitamin D3 supplementation in children and adolescents with sickle cell disease

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