Abstract:The objective of this study was to assess the performance of chick embryo motoneuron cultures for the study of neurotoxicants. The response of motoneurons to the cytotoxic effects of picrotoxin, strychnine, bulbocapnine, and the naturally occurring excitatory amino acids, N-methyl D-aspartate (NMDA) and L-glutamate was studied by using a colorimetric viability assay using a vital dye. Selective cellular responses other than cell death were evaluated using a spectrofluorometric assay based on the response of an… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.