Evaluation of chemotherapy-induced toxicity and health-related quality of life amongst early-stage breast cancer patients receiving Chinese herbal medicine in Malaysia

Liew, Ai Ch'i; Peh, Kok Khiang; Tan, Boon Seang; Zhao, Wei; Tangiisuran, Balamurugan

doi:10.1007/s00520-019-04724-1

Cited by 13 publications

(8 citation statements)

References 41 publications

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“…Consistent with previous occurrence rates of between 33% 1 and 60%, 1,3 47.2% of patients in our study reported CIN. In addition, similar to other studies, 8,28 more than 16% of our patients reported that their CIN was severe or very severe and more than 20% reported high levels of distress. Taken together, these findings confirm that despite the administration of combination antiemetic regimens, in 74% of the patients with CIN, this unrelieved symptom remains a significant clinical problem in the week before the patient’s next cycle of chemotherapy.…”

Section: Discussionsupporting

confidence: 91%

Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer

et al. 2022

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BackgroundUnrelieved chemotherapy-induced nausea (CIN) is a significant problem for patients with breast cancer (BC).ObjectiveIn a sample of patients with BC who were assessed before their second or third cycle of chemotherapy, study purposes were to evaluate for the occurrence, severity, frequency, and distress associated with CIN; evaluate for differences in demographic and clinical characteristics and gastrointestinal (GI) symptom occurrence rates between patients who did and did not report CIN; and determine which demographic, clinical, and symptom characteristics were associated with the occurrence of CIN.MethodsPatients completed demographic and clinical questionnaires and the Memorial Symptom Assessment Scale for nausea and common GI symptom assessments. Univariate analyses evaluated for differences in demographic and clinical characteristics and GI symptom occurrence between patients who did and did not report CIN. Multiple logistic regression analysis evaluated for characteristics associated with CIN.ResultsOf the 532 patients with BC, 47.2% reported CIN occurrence. Characteristics associated with CIN group membership were poorer functional status, receipt of chemotherapy on a 14-day cycle, and higher occurrence rates of 5 GI symptoms (ie, dry mouth, vomiting, constipation, change in the way food tastes, and lack of appetite; all P < .001).ConclusionsUnrelieved CIN is a common symptom in patients with BC. This study is the first to demonstrate that 5 co-occurring GI symptoms were associated with CIN occurrence.Implications for PracticeThis study identified new risk factors for CIN occurrence in patients with BC. Clinicians may be able to initiate additional interventions to alleviate CIN.

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Section: Discussionsupporting

confidence: 91%

Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer

et al. 2022

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“…Pooled data on comparative analyses of CHM + chemotherapy and chemotherapy alone revealed that CHM had greater beneficial effects on several indicators, including WBC, NEU, Hb, and PLT counts, as well as KPS, but not G-CSF dosage. The CHM + chemotherapy group was non-inferior to the PBO + chemotherapy group for the incidence of neutropenia, supporting the findings of Liew et al (2019) and Mok et al (2007) ; CHM did not reduce hematologic toxicity associated with chemotherapy. The CHM + chemotherapy group was superior to the WM + chemotherapy group in terms of improvement of the WBC counts, KPS score, infection amount, G-CSF use rate, and incidence of leukopenia.…”

Section: Discussionsupporting

confidence: 67%

Chinese Herbal Medicine for Chemotherapy-Induced Leukopenia: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Wang

et al. 2021

Front. Pharmacol.

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Aim: We conducted a systematic review of high-quality randomized controlled trials (RCTs) to assess the efficacy and safety of Chinese herbal medicine (CHM) for the treatment of chemotherapy-induced leukopenia (CIL).Methods: Eight electronic databases were searched from the date of inception to November 4, 2020 for high-quality RCTs that met the requirements of at least four key domains of the Cochrane risk of bias (RoB) tool. RevMan 5.3 was applied for the meta-analysis.Results: Fourteen RCTs involving 1,053 patients were included. The pooled results showed that CHM + chemotherapy exerted greater beneficial effects on white blood cell (WBC), neutrophil (NEU), hemoglobin (Hb), and platelet (PLT) counts in addition to the Karnofsky performance scale (KPS) score, but showed no significant difference on granulocyte colony-stimulating factor (G-CSF) dosage compared with chemotherapy alone. Placebo (PBO) + chemotherapy and CHM + chemotherapy groups showed no significant differences in terms of reduction of the incidence of neutropenia. CHM + chemotherapy was superior to Western medicine (WM) + chemotherapy in improving the WBC count, KPS, infection amount, G-CSF use rate, and incidence of leukopenia. In addition, no severe adverse events were observed in the 14 RCTs.Conclusion: CHM in combination with chemotherapy could effectively improve the clinical symptoms of CIL when compared with chemotherapy alone or Western medicine + chemotherapy, except when comparing with PBO + chemotherapy. While CHMs were generally safe for clinical use and exerted no severe side effects in the 14 RCTs, high-quality RCTs with larger sample sizes are essential to reduce study heterogeneity.

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“…Our data suggest that TCM diet can play a more comprehensive role as a therapy for alleviating side effects in patients undergoing chemotherapy (and/or radiotherapy). A prospective, non-randomized longitudinal study (Liew et al, 2019) indicated that Chinese herbs could reduce fatigue, nausea, and anorexia in breast cancer patients, but did not decrease chemotherapy-associated hematologic toxicity. It might due to the reason that it was a non-randomized controlled study, and too few cases, which may have an impact on the results.…”

Section: Discussionmentioning

confidence: 99%

Traditional chinese medicine diet paratherapy for alleviating toxicity in chemotherapy and radiotherapy in cancer patients: a meta-analysis

et al. 2021

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Evaluation of chemotherapy-induced toxicity and health-related quality of life amongst early-stage breast cancer patients receiving Chinese herbal medicine in Malaysia

Cited by 13 publications

References 41 publications

Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer

Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer

Chinese Herbal Medicine for Chemotherapy-Induced Leukopenia: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Traditional chinese medicine diet paratherapy for alleviating toxicity in chemotherapy and radiotherapy in cancer patients: a meta-analysis

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