Evaluation of chemical composition and antiedematogenic activity of the essential oil of Hyptis martiusii Benth

Abstract

Evaluations of the therapeutic potential of medicinal plants and their components have been the subject of many studies. Furthermore, the biological activities of various plant species have been reported in various pieces of literature. Benth (Lamiaceae), popularly known as "mad balm" is commonly found in the North, Southeast, and Northeast of Brazil. Its leaves are used ethnobiologically as antiulcerogenic, antimicrobial, antitumor and as insecticide. This study aimed to analyze the chemical composition of the essential oil of Benth (OEHM) by GC/MS as well as its possible topical activity as an antiedematogenic. This is verified by the models of ear edema induced by single (acute edema) and multiple (chronic edema) applications of croton oil topically, and systemically verified through the model of paw edema induced by carrageenan 1%. Doses of 50, 75 and 100 mg/kg OEHM were used in all tests. Chemical analysis of the oil revealed the 1,8-cineole (34.58%) and -carene (21:58%) as major components present in the essential oil. On the model of ear edema, acute and chronic OEHM in all the tested doses showed no significant antiedematogenic activity ( < 0.05). The systemic model of paw edema induced by carrageenin showed that a dose of 100 mg/kg effectively reduced swelling by 55.37% in the second hour evaluation when compared to the saline group. The anti-inflammatory systemic effect can give greater bioavailability of the components present in the essential oil and your interference in cytokines and leukotriene, thromboxane and prostaglandin biosynthesis. It is therefore concluded that OEHM presents systemic antiedematogenic activity but not topical activity at these doses.

Anti-Inflammatory Comparison of Melatonin and Its Bromobenzoylamide Derivatives in Lipopolysaccharide (LPS)-Induced RAW 264.7 Cells and Croton Oil-Induced Mice Ear Edema

“…Shin et al [ 38 ] indicated that application of croton oil increased expression of COX-1 and COX-2 and increased PGE 2 production. These mechanisms increase vascular permeability, vasodilation and swelling due to the release of histamine and serotonin, which is followed by the synthesis of leukotrienes and prostaglandins [ 39 ]. Therefore, anti-inflammatory drugs such as aspirin that inhibit COX enzymes are effective in suppressing ear edema induced by croton oil [ 40 , 41 ].…”

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

“…The essential oil of Medusantha martiusii (syn. Hyptis martiusii ), is composed predominantly by γ -3-carene ( 242 ) and 1,8-cineole ( 250 ) ( Caldas et al, 2014 ; Barbosa et al, 2017 ).…”

Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil

“…In this context, in the Lamiaceae family, there are a plethora of species with rich content in essential oils, which are used in popular medicine as an alternative treatment for diseases [2] . For example, the genus Hyptis is considered of great economic importance since it is composed of triterpenes [3] , diterpenes [4] and sesquiterpenes [5] , that are responsible for interesting antimicrobial [ 6 , 7 ], insecticide [8] , analgesic [9] , [10] , [11] , and hypnotic-sedative and antipsychotic-like activity [12] .…”