Evaluation of characteristics of the craniofacial complex and dental maturity in girls with central precocious puberty

Lee

Maxillofac Plast Reconstr Surg

et al. 2020

Background: Dental studies of precocious puberty have focused on examination of jaw and dentition growth. The aim of the study was to analyze the relationship between precocious puberty and maxillary dental developmental abnormalities (DDAs). Methods: This retrospective study was conducted on the Korean patients in whom dental panoramic and hand-wrist radiographs had been taken before they were 15 years of age. The maxillary DDAs were assessed as mesiodens, congenital missing teeth, peg-shape lateral incisors, or impacted teeth. The chronological ages of the control group members were within the normal range of the hand-wrist bone age. Others with a peak luteinizing hormone of ≥ 5 and < 5 IU/L were allocated to central precocious puberty (CPP) and peripheral precocious puberty (PPP), respectively. Results: Of the enrolled 270 patients, 195, 52, and 23 were allocated to the control, CPP, and PPP groups, respectively. The maxillary DDAs were significantly more prevalent in the CPP group than in the other groups. Among those with maxillary DDA, the mesiodens predominated. Age-and sex-adjusted multivariate analysis revealed maxillary DDA (odds ratio, 3.36; 95% CI, 1.60-7.05) and especially mesiodens (odds ratio, 5.52; CI, 2.29-13.28) to be significantly associated with CPP. Conclusions: Maxillary DDAs were significantly more prevalent in the CPP group than in the PPP or control groups. Among the many types of maxillary DDAs, mesiodens was significantly associated with CPP and may be considered a predictor of the development of CPP.

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of maxillary dental developmental abnormality with precocious puberty: a case-control study

Lee

Maxillofac Plast Reconstr Surg

et al. 2020

“…In idiopathic precocious puberty, Roberts et al found that dental ages were delayed in relation to their chronological age in children [27]. Conversely, the recent study by Lee et al revealed early maturation of the mandibular teeth in girls with central precocious puberty [28]. As far as delayed puberty is concerned, Gaethofs et al observed significant retardation of dental maturation in boys with CDGP.…”

Section: The Role Of Developmental Age Assessment In Girls With Delaymentioning

confidence: 99%

Application of auxological methods, including dental age estimation, in the assessment of delayed puberty in girls in gynecological practice

et al. 2019

Developmental gynecology uses methods practiced in auxology -the science of human ontogenetic development. An important and jointly used concept in gynecology and auxology is the concept of developmental age, which, unlike calendar age, is a measure of the biological maturity of the organism, indicating the stage of advancement in the development of certain features or body systems. Developmental age assessment methods include: a) morphological (somatic) age -body height and weight, b) secondary sex characteristics -breast in girls, genitalia (penis and testes) in boys, and pubic hair in both sexes, c) bone age -hand and wrist x-ray, and d) dental age. An important marker of developmental age is also age at menarche, treated as a late indicator of puberty in girls. All of these methods are useful in the context of assessing regularity and disorders of puberty, such as delayed puberty. The paper discusses developmental age assessment methods that can be used to diagnose delayed puberty as well as the causes of delayed puberty in girls. It should be emphasized that in assessing the process of physical development of a given individual, the cooperation of specialists in the field of developmental gynecology, pediatrics, auxology, dentistry, endocrinology, and dietetics would be the most desirable.

“…The control group included 48 normal healthy girls (mean age, 8.6 ± 0.7 years) who visited the Department of Orthodontics for orthodontic treatment and had no history of hormone treatment or growth problems. Based on data from previous studies, 7,14 the numbers of girls in each group were determined via G* Power ver. 3.1.9.2 (Dusseldorf University, Dusseldorf, Germany), with a pvalue < 0.05 indicating statistical significance.…”

Section: Study Sample and Designmentioning

confidence: 99%

“…Generally, the onset of sexual maturation before the age of 8 years in girls and 9 years in boys is considered abnormal. 6,7 Precocious puberty is classified as either central (GnRH-dependent) or peripheral (GnRH-independent), and central precocious puberty (CPP) accounts for approximately 80% of the cases.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cephalometric characteristics and skeletal maturation of the cervical vertebrae and hand-wrist in girls with central precocious puberty

et al. 2020

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This study aimed to evaluate the differences in cephalometric characteristics and skeletal maturation in girls with central precocious puberty (CPP) via lateral and hand-wrist radiographs. We also aimed to identify the indicators that are most effective for determining skeletal maturity in these patients. Methods: The study included 70 Korean girls (mean age, 8.5 ± 0.5 years) diagnosed with CPP at the Department of Pediatrics, and 48 normal healthy age-matched girls who visited the Department of Orthodontics and had no history of hormone treatment or growth problems. Skeletal maturation was evaluated using lateral cephalometric and hand-wrist radiographs using cervical vertebrae maturation indicators (CVMI) and skeletal maturity indicators (SMI). Results: The mean mandibular plane angle was smaller in the CPP group than in the control group (35.8 o ± 4.9 o vs. 39.0 o ± 6.5 o), resulting in greater posterior facial height (p = 0.003). SMI was significantly greater in the CPP group (3.5 ± 1.4 vs. 2.0 ± 1.0) than in the control group (p = 0.001) and was significantly associated with CPP (r = 0.492; p = 0.001), whereas CVMI was not. Conclusions: In comparison with the control group, the CPP group exhibited a smaller mandibular plane angle, greater posterior facial height, and greater skeletal maturation. SMI may be more suitable than CVMI for determining skeletal maturation in CPP. Hand-wrist radiography is recommended in addition to lateral cephalogram for predicting growth in girls with CPP.