Evaluation of characteristics and in vitro antioxidant properties of RSV loaded hyaluronic acid–DPPC microparticles as a wound healing system

Eroğlu, İpek; Gökçe, Evren; Tsapis, Nicolas; Tanrıverdi, Sakine Tuncay; Gökçe, Göksel; Özer, Özgen

doi:10.1016/j.colsurfb.2014.12.006

Cited by 49 publications

(30 citation statements)

References 44 publications

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“…One of the areas that this kind of products can be used is wound care especially in the form of wound dressings. Wound healing is known as a natural body response when the skin is damaged [2]. It is achieved through four programmed phases which are hemostasis, inflammation, proliferation, and remodeling.…”

Section: Introductionmentioning

confidence: 99%

<i>In-vitro</i> evaluation of dexpanthenol-loaded nanofiber mats for wound healing

Tanrıverdi¹,

Suat²,

Azizoğlu³

et al. 2018

Trop. J. Pharm Res

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To prepare a novel dexpanthenol (DEX)-loaded nanofiber mats for wound healing. Methods: A novel bioactive wound dressing formulation with dexpanthenol was developed by electrospinning method. Poly (lactic-co-glycolic acid), poly (ethylene oxide) and poly (caprolactone) were used as polymers. Morphological features, swelling properties, in-vitro release behavior, and cell viability properties of the formulations were evaluated.

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Section: Introductionmentioning

confidence: 99%

<i>In-vitro</i> evaluation of dexpanthenol-loaded nanofiber mats for wound healing

Tanrıverdi¹,

Suat²,

Azizoğlu³

et al. 2018

Trop. J. Pharm Res

Self Cite

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“…Similar results were observed in other HA hydrogel and HA-containing microparticles. [49] The results further prove that HA, as an important member of the cellular matrix, is able to enhance cell spreading, migration, and proliferation. [50] In addition, the relatively stiffer surfaces of crosslinked hydrogel particles, the uneven particle sizes, and the shapes of individual particles may increase the complexity of the local topography surrounding the cells, and thus may result in complex interactions with the cytoskeleton system.…”

Section: Subacute Cytotoxicitymentioning

confidence: 63%

Semi-interpenetrating network hyaluronic acid microgel delivery systems in micro-flow

Chen

Passos

Balabani

et al. 2018

Journal of Colloid and Interface Science

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Macroscopic hydrogels are commonly used as injectable scaffolds or fillers, however they may easily obstruct blood vessels, which poses risks and limits their clinical use. In the present study, three types of hyaluronic acid (HA)-based hydrogel micro-particles with non-covalent, covalent semi-interpenetrating and conventional 3D molecular networks, have been designed, fabricated and characterized. The micro-particles are spherical, biconcave or irregular in shape and their diameter ranged between 2.5 and 3.5 µm; their suspensions exhibit a tuneable viscosity, shear-thinning behaviour, dynamic stability and dispersity in microfluidic flow as a result of their specific particulate nature, providing thus a well-controlled injectable platform. Hydrogel particle suspensions also demonstrate an enhanced safety profile, in terms of the dispersity, cell safety, and hemocompatibility. In addition, Rhodamine 6G has successfully been loaded and released from the particles as a model for drug delivery. Functionalisation of hydrogel microparticles using synthetic polymers has been proven to be a cost-effective way to achieve desirable rheological properties and flow dynamic stability with improved physicochemical properties and biocompatibility in vitro, showing promise as a multifunctional biomedical material for various advanced surgical devices and therapies.

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“…It was shown that inhibiting oxidative stress in wounds can enhance the wound healing process. Therefore, antioxidant agents exhibit encouraging results in the wound healing process [ 6 ]. Radicals such as reactive oxygen species (ROS) play an important role in healing processes and in carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Natural Formulations Provide Antioxidant Complement to Hyaluronic Acid-Based Topical Applications Used in Wound Healing

et al. 2020

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Hyaluronic acid (HA) promotes wound healing, and, accordingly, formulations based on HA have been widely used in regenerative medicine. In addition, naturally derived compounds, e.g., plant-based extracts and vitamin E, have exhibited antioxidant activity. In this study, a formulation containing hyaluronic acid, vitamin E, raspberry extract, and green tea was developed for potential topical applications, targeting wound healing. Rheological analysis was performed along with antioxidant and biological studies. The rheological characterization showed that the HA-based formulation is a thixotropic platform and possesses higher mechanical properties than the control formulation. To evaluate the wound healing potential of the formulation, an in vitro “wound healing” assay was carried out using human derived fibroblasts (HDF) with a cell-free gap on the tissue culture dish. The formulation showed better wound healing ability than the control formulation.

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Evaluation of characteristics and in vitro antioxidant properties of RSV loaded hyaluronic acid–DPPC microparticles as a wound healing system

Cited by 49 publications

References 44 publications

<i>In-vitro</i> evaluation of dexpanthenol-loaded nanofiber mats for wound healing

<i>In-vitro</i> evaluation of dexpanthenol-loaded nanofiber mats for wound healing

Semi-interpenetrating network hyaluronic acid microgel delivery systems in micro-flow

Natural Formulations Provide Antioxidant Complement to Hyaluronic Acid-Based Topical Applications Used in Wound Healing

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