Evaluation of Changes in the Expression Pattern of EDIL3 in Different Grades of Endometrial Cancer

Opławski, Marcin; Dziobek, Konrad; Zmarzły, Nikola; Grabarek, Beniamin Oskar; Tomala, Barbara; Leśniak, Ewa; Adwent, Iwona; Januszyk, Piotr; Dąbruś, Dariusz; Boroń, Dariusz

doi:10.2174/1389201020666190408112822

Cited by 4 publications

(6 citation statements)

References 43 publications

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“…Proteins in the ECM are a focal component of the tumour microenvironment [ 19 ]. Significant changes in the basement membrane are observed during carcinogenesis.…”

Section: Resultsmentioning

confidence: 99%

Changes in the Extracellular Matrix in Endometrial and Cervical Cancer: A Systematic Review

Padežnik

Oleksy

Cokan

et al. 2023

IJMS

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Endometrial and cervical cancers are the two most common gynaecological malignancies and among the leading causes of death worldwide. The extracellular matrix (ECM) is an important component of the cellular microenvironment and plays an important role in developing and regulating normal tissues and homeostasis. The pathological dynamics of the ECM contribute to several different processes such as endometriosis, infertility, cancer, and metastasis. Identifying changes in components of ECM is crucial for understanding the mechanisms of cancer development and its progression. We performed a systematic analysis of publications on the topic of changes in the extracellular matrix in cervical and endometrial cancer. The findings of this systematic review show that matrix metalloproteinases (MMP) play an important role impacting tumour growth in both types of cancer. MMPs degrade various specific substrates (collagen, elastin, fibronectin, aggrecan, fibulin, laminin, tenascin, vitronectin, versican, nidogen) and play a crucial role in the basal membrane degradation and ECM components. Similar types of MMPs were found to be increased in both cancers, namely, MMP-1, MMP-2, MMP-9, and MMP-11. Elevated concentrations of MMP-2 and MMP-9 were correlated with the FIGO stage and are associated with poor prognosis in endometrial cancer, whereas in cervical cancer, elevated concentrations of MMP-9 have been associated with a better outcome. Elevated ADAMTS levels were found in cervical cancer tissues. Elevated disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) levels were also found in endometrial cancer, but their role is still unclear. Following these findings, this review reports on tissue inhibitors of ECM enzymes, MMPs, and ADAMTS. The present review demonstrates changes in the extracellular matrix in cervical and endometrial cancers and compared their effect on cancer development, progression, and patient prognosis.

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“…Proteins in the ECM are a focal component of the tumour microenvironment [ 19 ]. Significant changes in the basement membrane are observed during carcinogenesis.…”

Section: Resultsmentioning

confidence: 99%

Changes in the Extracellular Matrix in Endometrial and Cervical Cancer: A Systematic Review

Padežnik

Oleksy

Cokan

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…It is known that EDIL3, which is associated with various inflammatory pathologies, has recently played a role in many cancers including hepatocellular carcinoma, colorectal cancer, bladder cancer, and pancreatic adenocarcinoma [5][6][7][8][9]22]. In addition, it has been reported that EDIL3 is defined as a new angiogenic factor and induces endothelial cell growth of tumor cells with high expression and regulates angiogenesis, which can promote the formation of new blood vessels [21].…”

Section: Discussionmentioning

confidence: 99%

“…This protein is a molecular marker for embryonic endothelial cells and is rarely expressed after birth. However, it has been demonstrated that EDIL3/DEL1 was expressed in numerous types of cancer including colon cancer, bladder cancer, hepatocellular carcinoma [5][6][7][8][9]. Overexpressed EDIL3/ DEL1 expression causes tumor growth and metastasis through stimulation of neovascularization [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Identification of relationships among EDIL3, angiogenesis and inflammation in colorectal cancer: In-silico analysis

Sagkan,

Bali

2021

Ann Clin Anal Med

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Aim: The relationship between inflammation and the development of colorectal adenocarcinoma has been described for a number of years. In this cancer, chronic inflammation causes cellular damage and DNA mutations responsible for the proliferation of transformed cells. Epidermal growth factor-like repeats and discoidin I-like domains 3 (EDIL3/DEL-1) were anti-inflammatory protein, especially in epithelial cells. Our study, it was aimed to clarify the link of among IL-17A, EDIL3/DEL1, and the main angiogenic factor VEGFA/B in colorectal cancer. Materials and Methods: We investigated EDIL3, IL-17, and VEFGA/B mutations profile and levels of m-RNA expressions in 594 colorectal cancer patients using bioinformatics analysis for the revealing relationship among these molecules. Additionally, PolyPhen-2 and SNAP tools were used to predict and confirm the pathogenicity of the detected mutations. Results: In colorectal cancer patients, the IL-17 and EDIL3 expressions were inversely correlated but the low correlation coefficient was statistically significant. EDIL3 and VEGFB m-RNA levels were found to be statistically significantly lower in the patient group than in the healthy group. Furthermore, 10 mutations were identified in the EDIL3. The study predicted the potential pathological effect of eight mutations in the EDIL3. Discussion: Low expression of EDIL3 might contribute to anti-inflammation, supporting extravasation of leukocytes to inflammatory area by increased IL-17 expression. Although further studies to clarify the mechanisms explaining the role of EDIL3 in tumor angiogenesis in terms of VEGF gene, and the interaction between IL-17 and EDIL3 are required, the results indicate that EDIL3 may be a good novel molecular target gene in inflammatory pathways for colorectal cancer.

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“…It also enhances the tumorigenic, metastatic, and angiogenic potential through TGF-β and ERK signaling in hepatocellular carcinoma [ 32 ]. In addition, it is increased in endometrial, colon, bladder, and pancreatic cancers [ 33 – 36 ]. Del-1 appears to be negatively correlated with some types of cancers.…”

Section: Elevated Levels and Progression-promoting Effects Of Del-1 In Cancermentioning

confidence: 99%

Regulatory role of local tissue signal Del-1 in cancer and inflammation: a review

Zhong

2021

Cell Mol Biol Lett

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Developmental endothelial locus-1 (Del-1) is a secretory, multifunctional domain protein. It can bind to integrins and phosphatidylserine. As a local tissue signal, it plays a regulatory role in the cancer microenvironment and inflammation. Del-1 has destructive effects in most cancers and is associated with the progression and invasion of some cancers. In contrast, Del-1 also plays a protective role in inflammation. Del-1 regulates inflammation by regulating the generation of neutrophils in bone marrow, inhibiting the recruitment and migration of neutrophils and accelerating the clearance of neutrophils by macrophages. Del-1 and IL-17 are reciprocally regulated, and their balance maintains immune system homeostasis. Del-1 is expected to become a new therapeutic target for inflammatory disorders such as multiple sclerosis.

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Evaluation of Changes in the Expression Pattern of EDIL3 in Different Grades of Endometrial Cancer

Cited by 4 publications

References 43 publications

Changes in the Extracellular Matrix in Endometrial and Cervical Cancer: A Systematic Review

Changes in the Extracellular Matrix in Endometrial and Cervical Cancer: A Systematic Review

Identification of relationships among EDIL3, angiogenesis and inflammation in colorectal cancer: In-silico analysis

Regulatory role of local tissue signal Del-1 in cancer and inflammation: a review

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