Evaluation of changes in the faecal resistome associated with children's exposure to domestic animals and food animal production

Cifuentes, Sara G.; Graham, Jay P.; Loayza, Fernanda; Saraiva-Garcia, Carlos; Salinas, Liseth; Trueba, Gabriel; Cárdenas, Paúl

doi:10.1016/j.jgar.2022.09.009

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…A higher pooled estimate of antibiotic resistance (86%) and multidrug resistance (73%) was also reported in a review study in Africa [ 65 ]. Surface contamination with fecal matter, animal excreta, and water or soil sources may allow the transmission of drug-resistant bacterial populations to raw meat and carcasses, which could be transmitted to humans through consumption of animal products [ 66 – 69 ]. Additionally, the frequent contact between humans, dairy cattle, and poultry may also be a good opportunity for the bidirectional transmission of AMR bacteria such as E. coli [ 60 , 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

“…Surface contamination with fecal matter, animal excreta, and water or soil sources may allow the transmission of drug-resistant bacterial populations to raw meat and carcasses, which could be transmitted to humans through consumption of animal products [ 66 – 69 ]. Additionally, the frequent contact between humans, dairy cattle, and poultry may also be a good opportunity for the bidirectional transmission of AMR bacteria such as E. coli [ 60 , 69 , 70 ]. Hence, the frequent contact with dairy cattle and poultry products as well as the habitual consumption of raw meat and milk may be contributing factors in the acquisition of resistance bacteria.…”

Section: Discussionmentioning

confidence: 99%

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Drug resistance and extended-spectrum β-lactamase (ESBLs) - producing Enterobacteriaceae, Acinetobacter and Pseudomonas species from the views of one-health approach in Ethiopia: a systematic review and meta-analysis

Abayneh,

Zeynudin,

Tamrat

et al. 2023

One Health Outlook

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Background Although antimicrobial resistance (AMR) bacteria present a significant and ongoing public health challenge, its magnitude remains poorly understood, especially in many parts of the developing countries. Hence, this review was conducted to describe the current pooled prevalence of drug resistance, multidrug- resistance (MDR), and Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, Acinetobacter, and Pseudomonas species in humans, the environment, and animals or food of animal origin in Ethiopia. Methods PubMed, Google Scholar, and other sources were searched for relevant articles as per the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. A critical appraisal for screening, eligibility, and inclusion in the meta-analysis was made based on the Joanna Briggs Institute’s (JBI) essential appraisal tools. The meta-analysis was done on Statistical Software Package (STATA) version 17.0. Results A total of 33 research articles were included in this systematic review and meta-analysis. Escherichia coli, Klebsiella species, Acinetobacter, and Pseudomonas species were the most frequently reported bacteria from two or more sources. More than 50% of Klebsiella species and 25% to 89% of Escherichia coli from two or more sources were resistant to all analysed antibiotics, except carbapenems. Fifty-five percent (55%) to 84% of Acinetobacter species and 33% to 79% of Pseudomonas species from human and environmental sources were resistant to all analyzed antibiotics. Carbapenem resistance was common in Acinetobacter and Pseudomonas species (38% to 64%) but uncommon in Enterobacteriaceae (19% to 44%). Acinetobacter species (92%), Klebsiella species (86%), and Pseudomonas species (79%) from human sources, and Proteus species (92%), and Acinetobacter species (83%), from environmental sources, were the common multidrug-resistant isolates. About 45% to 67% of E. coli, Klebsiella, Acinetobacter, and Pseudomonas species from human and environmental sources were ESBL producers. Conclusion Our review report concluded that there was a significant pooled prevalence of drug resistance, MDR, and ESBL-producing Enterobacteriaceae, Acinetobacter, and Pseudomonas species from two or more sources. Hence, our finding underlines the need for the implementation of integrated intervention approaches to address the gaps in reducing the emergence and spread of antibiotic- resistant bacteria.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Drug resistance and extended-spectrum β-lactamase (ESBLs) - producing Enterobacteriaceae, Acinetobacter and Pseudomonas species from the views of one-health approach in Ethiopia: a systematic review and meta-analysis

Abayneh,

Zeynudin,

Tamrat

et al. 2023

One Health Outlook

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“…Despite the strong antimicrobial-selective pressure that can be expected after antibiotic use [ 47 , 94 ], the infant gut microbiota and resistome can be affected by different factors, such as the vertical transmission and perinatal factors mentioned above; it can also be due to contact with a pet or the use of antibiotics in agriculture and farms, thus affecting the ARGs levels [ 118 , 123 ]. An increment in ARGs in commensal bacteroides in the gut microbiota of healthy people in recent years was observed, but information in infants is not yet available.…”

Section: Impact Of Increased Levels Of Args On Health and Mitigation ...mentioning

confidence: 99%

Old Folks, Bad Boon: Antimicrobial Resistance in the Infant Gut Microbiome

et al. 2023

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The development of the intestinal microbiome in the neonate starts, mainly, at birth, when the infant receives its founding microbial inoculum from the mother. This microbiome contains genes conferring resistance to antibiotics since these are found in some of the microorganisms present in the intestine. Similarly to microbiota composition, the possession of antibiotic resistance genes is affected by different perinatal factors. Moreover, antibiotics are the most used drugs in early life, and the use of antibiotics in pediatrics covers a wide variety of possibilities and treatment options. The disruption in the early microbiota caused by antibiotics may be of great relevance, not just because it may limit colonization by beneficial microorganisms and increase that of potential pathogens, but also because it may increase the levels of antibiotic resistance genes. The increase in antibiotic-resistant microorganisms is one of the major public health threats that humanity has to face and, therefore, understanding the factors that determine the development of the resistome in early life is of relevance. Recent advancements in sequencing technologies have enabled the study of the microbiota and the resistome at unprecedent levels. These aspects are discussed in this review as well as some potential interventions aimed at reducing the possession of resistance genes.

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Evaluation of changes in the faecal resistome associated with children's exposure to domestic animals and food animal production

Cited by 2 publications

References 18 publications

Drug resistance and extended-spectrum β-lactamase (ESBLs) - producing Enterobacteriaceae, Acinetobacter and Pseudomonas species from the views of one-health approach in Ethiopia: a systematic review and meta-analysis

Drug resistance and extended-spectrum β-lactamase (ESBLs) - producing Enterobacteriaceae, Acinetobacter and Pseudomonas species from the views of one-health approach in Ethiopia: a systematic review and meta-analysis

Old Folks, Bad Boon: Antimicrobial Resistance in the Infant Gut Microbiome

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