Evaluation of changes in oxyhemoglobin during Shiritori task in elderly subjects including those with Alzheimer‧s disease

Kato, Yusuke; Yamanaka, Shōji; Morita, Kenichi; Inoue, M.; Ishii, Yukihiro; Sato, M.; Yamashita, Yuuji; Okawa, Junji; Uchimura, Naohisa

doi:10.1111/psyg.12226

Cited by 12 publications

(14 citation statements)

References 37 publications

(48 reference statements)

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“…Based on above preprocessing methods, two parameters – mean change of HbO concentration (MHbO) and the slope of the HbO change (SPHbO) – were derived for each of the four groups. As suggested by previous studies, change in HbO concentration generally indicates the metabolic activity of local neurons, which is tied to functional activity and may take more than 10-sec to reach a significant activation level ( Khan et al, 2014 ; Kato et al, 2017 ). We therefore computed the MHbO from each brain region using a 3–12 s window.…”

Section: Methodsmentioning

confidence: 81%

Early Detection of Alzheimer’s Disease Using Non-invasive Near-Infrared Spectroscopy

Rui²,

Chen³

et al. 2018

Front. Aging Neurosci.

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Mild cognitive impairment (MCI) is a cognitive disorder characterized by memory impairment, wherein patients have an increased likelihood of developing Alzheimer’s disease (AD). The classification of MCI and different AD stages is therefore fundamental for understanding and treating the disease. This study aimed to comprehensively investigate the hemodynamic response patterns among various subject groups. Functional near-infrared spectroscopy (fNIRS) was employed to measure signals from the frontal and bilateral parietal cortices of healthy controls (n = 8), patients with MCI (n = 9), mild (n = 6), and moderate/severe AD (n = 7) during a digit verbal span task (DVST). The concentration changes of oxygenated hemoglobin (HbO) in various subject groups were thoroughly explored and tested. Result revealed that abnormal patterns of hemodynamic response were observed across all subject groups. Greater and steeper reductions in HbO concentration were consistently observed across all regions of interest (ROIs) as disease severity developed from MCI to moderate/severe AD. Furthermore, all the fNIRS-derived indexes were found to be significantly and positively correlated to the clinical scores in all ROIs (R ≥ 0.4, P < 0.05). These findings demonstrate the feasibility of utilizing fNIRS for the early detection of AD, suggesting that fNIRS-based approaches hold great promise for exploring the mechanisms underlying the progression of AD.

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Section: Methodsmentioning

confidence: 81%

Early Detection of Alzheimer’s Disease Using Non-invasive Near-Infrared Spectroscopy

Rui²,

Chen³

et al. 2018

Front. Aging Neurosci.

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“…In this study, the hemoglobin concentration peaked at 96 h, followed by a decrease, although it was still significantly higher than in the control group. In addition to carrying oxygen, hemoglobin can store energy and maintain osmotic pressure and antibacterial activity (Wang et al, 2013;Kato et al, 2017). Therefore, with sudden changes of salinity, because S. subcrenata lacks a specific immune system, it has to rely on the innate immunity of blood cells and humoral factors to enhance its resistance in response to external environmental stress.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sudden Drop in Salinity on Osmotic Pressure Regulation and Antioxidant Defense Mechanism of Scapharca subcrenata

Zhang

Liu

et al. 2020

Front. Physiol.

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Salinity is an important ecological factor that impacts the growth and survival of aquatic organisms. The salinity of seawater in coastal and estuarine areas is often subject to dynamic changes because of seasonal rainfall and continental runoff. Thus, the current study investigated the effects of sudden changes in salinity on the survival rate and osmotic pressure regulation mechanisms of bottom-sowing seedlings of the economically important ark shell, Scapharca subcrenata. By simulating the sudden changes that occur in seawater salinity after rainstorms, the results showed that the osmotic pressure of the hemolymph and Na + , K + , Ca 2+ , and Cl − concentrations first decreased and then increased. When the salinity decreased from 30 to 14 , hemoglobin, soluble total protein, taurine, and total free amino acid gradually increased; maximum levels of hemoglobin, soluble total protein, and taurine occurred once the salinity increased to 22 at 96 h. After 96 h, the total free amino acid content increased until 144 h. The reactive oxygen species (ROS) content and total antioxidant capacity (T-AOC) peaked at 96 h, whereas the expression levels of Mn-superoxide dismutase (MnSOD) and catalase (CAT) increased earlier, indicating that, with continuous ROS generation, antioxidant defense mechanisms were activated to avoid oxidative damage. Expression levels of cathepsin C (CTSC), cathepsin D (CTSD), heat shock protein 20 (HSP20), and heat shock protein 70 (HSP70) were significantly higher than in the control group at 48 h (salinity level 14); the expression levels of HSP20, heat shock protein 90 (HSP90), MnSOD, and glutathione peroxidase (GP x) remained high, indicating that they were still required for osmotic pressure regulation to maintain the dynamic balance between the generation and removal of ROS as the salinity level increased. These results not only add to our basic understanding of the aquatic ecology of S. subcrenata, but also provide a theoretical ground for improving the survival rate of bottom-sowing, propagation, and release of S. subcrenata seedlings.

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“…As a method of NIRS measurement, we chose a single‐event‐related design. This is a method to apply short stimulations one by one in a control state, and multiple and weak stimulations are required compared with the block design . Although it removes artifacts on analysis, there is a merit in that waveforms can be precisely analyzed one by one, and it is considered to be able to capture brain activity more sensitively.…”

Section: Methodsmentioning

confidence: 99%

“…This is a method to apply short stimulations one by one in a control state, and multiple and weak stimulations are required compared with the block design. 32 Although it removes artifacts on analysis, there is a merit in that waveforms can be precisely analyzed one by one, and it is considered to be able to capture brain activity more sensitively. Each subject performed the task while sitting on a chair in the examination room, which blocked sounds or unnecessary visual stimuli.…”

Section: Task Designmentioning

confidence: 99%

Comparison of changes in the oxygenated hemoglobin level during a ‘modified rock‐paper‐scissors task’ between healthy subjects and patients with schizophrenia

Sato

Yamanaka

Morita

et al. 2018

Psychiatry Clin Neurosci

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Evaluation of changes in oxyhemoglobin during Shiritori task in elderly subjects including those with Alzheimer‧s disease

Cited by 12 publications

References 37 publications

Early Detection of Alzheimer’s Disease Using Non-invasive Near-Infrared Spectroscopy

Early Detection of Alzheimer’s Disease Using Non-invasive Near-Infrared Spectroscopy

Effects of Sudden Drop in Salinity on Osmotic Pressure Regulation and Antioxidant Defense Mechanism of Scapharca subcrenata

Comparison of changes in the oxygenated hemoglobin level during a ‘modified rock‐paper‐scissors task’ between healthy subjects and patients with schizophrenia

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