Evaluation of chalcones derivatives in lipid peroxidation reduction induced by Fe2+/EDTA in vitro

Silva, Jadyellen Rondon e; Souza, Anderson de Oliveira; Anjos, Italo Curvelo dos; Pádua, Geilly Mara Silva de; Vieira, Lucas Campos Curcino; Gai, Bibiana Mozzaquatro

doi:10.33448/rsd-v12i1.39541

Cited by 1 publication

(3 citation statements)

References 15 publications

(15 reference statements)

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“…The obtained data align with previous reports regarding the poor ability of chalcone derivative compounds to scavenge free radicals [ 58 ]. According to the literature, utilization of DPPH for the antiradical assessment of chalcone–sulfonamide hybrids presented a range of results depending on the moiety.…”

Section: Resultssupporting

confidence: 91%

“…Additionally, the other compounds 4, 6, 7, and 8 were unable to react with the ABTS radical. The obtained data align with previous reports regarding the poor ability of chalcone derivative compounds to scavenge free radicals [58]. According to the literature, utilization of DPPH for the antiradical assessment of chalcone-sulfonamide hybrids presented In DPPH and ABTS assays, the results indicated a limited capacity of the tested chalcone derivatives to scavenge free radicals.…”

Section: Antioxidant Activitysupporting

confidence: 89%

“…The β-carotene bleaching method is used in vitro to determine lipid peroxidation based on the loss of the yellow color of β-carotene due to the reaction with linoleic acid and subsequent oxidation in an emulsion. This rate of β-carotene bleaching can be slowed down in the presence of antioxidants, and according to the literature, chalcones have the potential to reduce lipid peroxidation [ 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

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New Chalcone Derivatives Containing 2,4-Dichlorobenzenesulfonamide Moiety with Anticancer and Antioxidant Properties

Bułakowska,

Sławiński,

Hering

et al. 2023

IJMS

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Chalcones and their derivatives, both natural and synthetic, exhibit diverse biological activities. In this study, we focused on designing and synthesizing (E)-2,4-dichloro-N-(4-cinnamoylphenyl)-5-methylbenzenesulfonamides 4–8 with the following two pharmacophore groups: 2,4-dichlorobenzenesulfonamide and chalcone. The obtained compounds displayed notable anticancer effects on various human cancer cells, such as cervical HeLa, acute promyelocytic leukemia HL-60, and gastric adenocarcinoma AGS, when assessed with the MTT test. The activity of all compounds against cancer cells was significant, and the obtained IC50 values were in the range of 0.89–9.63 µg/mL. Among all the tested compounds, derivative 5 showed the highest activity on the AGS cell line. Therefore, it was tested for cell cycle inhibition, induction of mitochondrial membrane depolarization, and activation of caspase-8 and -9. These results showed that this compound strongly arrested the cell cycle in the subG0 phase, depolarized the mitochondrial membrane, and activated caspase-8 and -9. Similar to the anticancer effects, all the obtained compounds 4–8 were also assessed for their antioxidant activity. The highest antiradical effect was demonstrated for derivative 5, which was able to inhibit DPPH and ABTS radicals. All examined compounds showed dose-dependent activity against neutrophil elastase. Notably, derivatives 7 and 8 demonstrated inhibitory properties similar to oleanolic acid, with IC50 values of 25.61 ± 0.58 and 25.73 ± 0.39 µg/mL, respectively. To determine the antibacterial activity of derivatives 4–8, the minimum bacteriostatic concentration (MIC) values were estimated (>500 µg/mL for all the tested bacterial strains). The findings demonstrate the substantial potential of sulfonamide-based chalcone 5 as a promising drug in anticancer therapy.

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Section: Resultssupporting

confidence: 91%

Section: Antioxidant Activitysupporting

confidence: 89%