Evaluation of cerebral blood flow by single-photon emission computed tomography in young Asian Indians with hypertension

Abstract

The objective of the study was to investigate abnormalities of regional cerebral blood flow (rCBF) in young (age 33.076.3 years; range 21-45 years) non-diabetic and normolipidemic Asian Indians with hypertension. The rCBF was assessed with single-photon emission computed tomography (SPECT) in patients with hypertension (n ¼ 33) and healthy controls (n ¼ 20). The SPECT findings were normal in 41 subjects and showed abnormalities of cerebral perfusion in 10 subjects, all of which were hypertensive patients. These observations are extremely important for a vast number of young hypertensive patients in India. To prevent cerebrovascular accidents in future, patients with hypertension and decreased rCBF should be carefully monitored and their hypertension should be strictly controlled. These subjects may also be researched as potential candidates for preventive antiplatelet therapy.

Olmesartan, an Angiotensin II Receptor Blocker, Restores Cerebral Hypoperfusion in Elderly Patients With Hypertension

“…11 Previous studies have noted brain hypoperfusion in hypertensive subjects, even those subjects with no neurologic symptoms. 1,2 The most vulnerable CBF regions in persons with hypertension vary. The reduction in regional CBF is most marked in the frontal and temporal lobes 1 or in the upper frontal, posterior parietal, and occipital regions.…”

“…Cerebral blood flow (CBF) is disturbed in hypertensive patients with no previous history of stroke. [1][2][3] Angiotensin II receptor blockers (ARBs) are used widely to treat hypertension. Recently, the protective effects of ARBs on target organs also have received attention.…”

Vascular health risks and fMRI activation during a memory task in older adults

“…Additionally, hypertension has been associated with reduced regional cerebral blood flow in healthy adults at rest (Meyer et al, 1985; Sinha et al, 2005). One previous study that used 15 O-water tracer PET to measure regional cerebral blood flow found that hypertensive participants had reduced overall cerebral blood flow compared with normotensive participants (Jennings, 2003).…”

Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND)

“…Inconsistency in results possibly arises due to differences in the use of subjective visual rating scales to assess the extent of pathology across groups, regional focus of disease (global versus focal), in addition to differences in enrolment criteria and the type and severity of vascular disease across imaging cohorts. Indeed, different vascular disease factors are associated with varying types and levels of pathology: hypertension has been associated with reduced cerebral blood flow [83] and an increased risk of periventricular white matter lesions [84,85]; lower arterial oxygen saturation and chronic obstructive pulmonary disease have been associated with cerebral white matter lesions, but not lacunar infarcts [86]; diabetes has been associated with cortical and hippocampal atrophy [87,88], white matter lesions [89] and lacunar infarcts [89]; and current smoking status, diabetes and hypertension are associated with both neurodegenerative (that is, decreased brain volume) and vascular (that is, lacunar infarcts and white matter lesions) changes [90]. …”