Evaluation of CEM43°CT90 Thermal Dose in Superficial Hyperthermia

Bruijne, Maarten de; Holt, Bronno van der; Rhoon, Gerard C. van; Zee, Jacoba van der

doi:10.1007/s00066-010-2146-x

Cited by 47 publications

(46 citation statements)

References 28 publications

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“…Clinical studies have shown that tumour control realised by adjuvant hyperthermia is correlated with the target temperatures that can be achieved and especially the minimum temperature T 90 is important for clinical outcome [4,[40][41][42]. For temperatures above 43…”

Section: Discussionmentioning

confidence: 99%

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A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia

Kok

Crezee

2017

International Journal of Hyperthermia

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Background: Superficial hyperthermia is applied in combination with radiotherapy for e.g. melanoma and recurrent breast cancer, using both capacitive and radiative systems. In this paper, numerical simulations are applied to address the question which technique yields the most favourable heating characteristics. Methods: A 434 MHz contact flexible microstrip applicator (CFMA type 4H, size 19.6 Â 19.6 cm 2 ) and a capacitive system consisting of two circular electrodes with diameter 15 and 25 cm were modelled. The water bolus of the CFMA was filled with deionised water and for capacitive heating both saline and deionised water were modelled. Specific absorption rate (SAR) and temperature simulations were performed for a perfused muscle-equivalent phantom and phantoms with a 1 cm thick superficial fat layer, assuming cylindrical target regions. Subsequently, a real patient model with a chest wall recurrence was studied with the target assumed to have muscle-like properties, fat properties or heterogeneous properties as derived from the CT Hounsfield Units. Results: Phantom simulations showed that high SAR peaks occur around the bolus edges with capacitive heating. Power absorption below the fat layer is substantially higher for radiative heating and unless the target region is limited to the fat layer, radiative heating yields better target coverage in terms of SAR and temperature. Patient simulations showed that the T 90 for radiative heating was 0.4-1.1 C higher compared with capacitive heating. Conclusions: Radiative heating yields more favourable SAR and temperature distributions for superficial tumours, compared with capacitive heating, especially within heterogeneous tissues. Higher tumour temperatures are achieved without occurrence of treatment limiting hot spots.

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Section: Discussionmentioning

confidence: 99%

“…the thermal dose realised in the target region [4]. The goal temperature during hyperthermia is typically 43 C [5] and the thermal dose achieved is therefore usually expressed as the number of equivalent minutes at 43 C, calculated using the CEM43 formula [6,7].…”

Section: Introductionmentioning

confidence: 99%

A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia

Kok

Crezee

2017

International Journal of Hyperthermia

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“…Additionally the CEM43°CT90 represents the thermal isoeffect dose expressed in cumulative equivalent minutes at a reference temperature of 43°C. The formulation for CEM43°CT90 used in this study has been used extensively and has been previously described [7,8,[9][10][11].…”

Section: Hyperthermiamentioning

confidence: 99%

Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients

Linthorst

Baaijens

Wiggenraad

et al. 2015

Radiotherapy and Oncology

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“…Temperature probes are preferentially placed in the target volume or in the vicinity of the target volume in order to acquire tumor-related temperatures. To preserve healthy tissue and possible risk organs, other probes are placed appropriately, including a record of the systemic temperature [2,4,8].…”

Section: Quantities and Unitsmentioning

confidence: 99%

Quality assurance for clinical studies in regional deep hyperthermia

et al. 2011

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Evaluation of CEM43°CT90 Thermal Dose in Superficial Hyperthermia

Abstract: In this retrospective study, no clear CEM43 degrees CT90 thermal dose targets or associations with clinical endpoints could be established.

Cited by 47 publications

References 28 publications

A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia

A comparison of the heating characteristics of capacitive and radiative superficial hyperthermia

Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients

Quality assurance for clinical studies in regional deep hyperthermia

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