“…Detective quantum efficiency (DQE), which is a function of MTF, NPS, and system gain, is the most commonly used metric to quantify the overall performance of X-ray imaging systems [ 4 , 5 , 6 ]; however, DQE cannot reflect entire imaging chains, such as image processing and correction [ 7 ]. In contrast, a more practical approach to quantifying overall image quality of a radiograph is to use contrast-detail phantoms [ 8 , 9 , 10 , 11 , 12 ]. Previously, an emerging metric, termed as mutual information (MI), was shown to successfully quantify the overall image quality of a digital radiograph with the use of a linear step-wedge phantom [ 13 , 14 ].…”