Evaluation of CD43 Expression in Non-Hematologic Malignancies

Batdorf, Bjorn; Kroft, Steven H.; Hosking, Paul; Harrington, Alexandra M.; Mackinnon, Alexander C.; Olteanu, Horatiu

doi:10.1093/ajcp/142.suppl1.244

Cited by 2 publications

(2 citation statements)

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“…In controversy to the above study, the haploid efficiency of a transcriptional repressor of c-Myc gene, FUSE-binding protein (FBP)-interacting repressor (FIR) resulted in the alternative splicing of PKM2 by inhibiting hnRNPAI expression [85]. Apart from these signaling molecules, some co-stimulatory molecules found on T-cell surface like CD43 also affect PKM2 expression and proliferation, activation and migration of T cells [86]. CD43 and TCR cosignaling stimulates the phosphorylation of Y105 of PKM2 and Y705 of Signal transducer and activator of transcription 3 (STAT3) transducer molecules resulting in the activation of MEPK5/ERk5 pathway which activates nuclear localization kappa B (NF-kB), Myc as well as Bcl-2-associated death promoter (BAD) phosphorylation promoting the survival [87].…”

Section: T Cellsmentioning

confidence: 93%

“…CD43 and TCR cosignaling stimulates the phosphorylation of Y105 of PKM2 and Y705 of Signal transducer and activator of transcription 3 (STAT3) transducer molecules resulting in the activation of MEPK5/ERk5 pathway which activates nuclear localization kappa B (NF-kB), Myc as well as Bcl-2-associated death promoter (BAD) phosphorylation promoting the survival [87]. Abnormal expression of this protein is also observed in some non-hematologic neoplasms such as lung, colon, and salivary gland cancers [86]. Even the siRNA silencing of CD43 increased the vulnerability of breast and lung cancer cells to NK cells and apoptosis [88,89].…”

Section: T Cellsmentioning

confidence: 99%

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Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment

Rihan

Nalla

Dharavath

et al. 2019

Cancer Microenvironment

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Metabolic reprogramming is a newly emerged hallmark of cancer attaining a recent consideration as an essential factor for the progression and endurance of cancer cells. A prime event of this altered metabolism is increased glucose uptake and discharge of lactate into the cells surrounding constructing a favorable tumor niche. Several oncogenic factors help in promoting this consequence including, pyruvate kinase M2 (PKM2) a rate-limiting enzyme of glycolysis in tumor metabolism via exhibiting its low pyruvate kinase activity and nuclear moon-lightening functions to increase the synthesis of lactate and macromolecules for tumor proliferation. Not only its role in cancer cells but also its role in the tumor microenvironment cells has to be understood for developing the small molecules against it which is lacking with the literature till date. Therefore, in this present review, the role of PKM2 with respect to various tumor niche cells will be clarified. Further, it highlights the updated list of therapeutics targeting PKM2 pre-clinically and clinically with their added limitations. This upgraded understanding of PKM2 may provide a pace for the reader in developing chemotherapeutic strategies for better clinical survival with limited resistance.

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Section: T Cellsmentioning

confidence: 93%

Section: T Cellsmentioning

confidence: 99%

Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment

Rihan

Nalla

Dharavath

et al. 2019

Cancer Microenvironment

View full text Add to dashboard Cite

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Expresión de CD43, piruvato cinasa II y hexocinasa II en carcinoma epidermoide cervicouterino

Alcántara-Quintana

Gallegos-García

Terán-Figueroa

2019

IyCUAA

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El cáncer cervicouterino (CaCu) es la segunda causa de muerte en México. La infección por el virus del papiloma humano es una condición necesaria durante el proceso de carcinogénesis. Una de las características del CaCu es que presenta un metabolismo alterado, las células tienden a captar más eficientemente la glucosa y aumentar la glucólisis. La glucosilación aberrante es un sello distintivo de algunos tipos de cáncer, que refleja cambios, como la expresión alterada de glucosiltransferasas y glucosidasas. Por tanto, el objetivo del presente trabajo fue describir el patrón de expresión de las proteínas CD43, piruvato cinasa II, y hexocinasa II en tejido cervical sano, tejido con cáncer cervicouterino y en lineas celulares de CaCu. Hasta el momento se encontró una mayor expresión de las proteínas al compararse con los tejidos sanos. Sin embargo, aun faltarían estudios para demostrar si pueden utilizarse como factor pronóstico para las pacientes conCaCu epidermoide.

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Evaluation of CD43 Expression in Non-Hematologic Malignancies

Cited by 2 publications

References 0 publications

Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment

Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment

Expresión de CD43, piruvato cinasa II y hexocinasa II en carcinoma epidermoide cervicouterino

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