Evaluation of Causative Factors in Amlodipine Induced Pedal Edema

Abstract

Objective: To study the edema causing factors in hypertensive, amlodipine-induced pedal edema patients.Methods: The present was a prospective, observational study. A total of one hundred and twenty-four essential hypertensive patients, of either gender attending the outpatient department of cardiology and medicine, were recruited for this study. Out of the 124 patients, 62 were of the amlodipine-induced pedal edema [AIPE] group and other 62 patients were amlodipine-treated non-edema [ATNE] group. All the patients were receiving a dosage of amlodipine 5 mg/day. All recruited patients completed the study. The present study conducted at Kasturba Hospital, Manipal.Results: The vanillyl mandelic acid (VMA) (mean±SD) 7.08±2.3 mg/24 h and 4.9±1.7 mg/24 h in AIPE and ATNE groups respectively. Blood pressure (BP) and VMA was higher in AIPE group than the ATNE group (p<0.001). Pulse rate (PR), serum proteins, creatinine, sodium, osmolality, did not show any significant difference between the two study groups.Conclusion: In essential hypertensive patients with AIPE group presented with a higher VMA level than the ATNE group. The elevated catecholamine’s possibly the causative factor for AIPE.

Assesment of Clinical Effectiveness of Losartan and Amlodipine in Hypertensive Patient With Left Ventricular Hypertrophy

“…Correlation between SBP and LVMI was found to be 0.17 and 0.2 in losartan and amlodipine, respectively (Table 9); correlation between DBP and LVMI was found to be 0.21 in losartan patients and 0.41 in amlodipine patients (Table 10). The ADR events of both groups were monitored and it was observed that only patients in amlodipine group experienced ADR such as peripheral edema [22], which was comparable with ADR occurred in Rosendorff et al's [23] study.…”

A Tbx5 Nonsense Mutation in Siblings With Divergent Phenotypes Associated With Isolated Septal Defects

“…The cross-species alignment of TBX5 protein showed that the altered tryptophan residue is evolutionarily conserved throughout the vertebrates, indicating its functional importance [22]. The understanding of the genetic mutations is an important aspect in deciphering the consequential clinical phenotypes [23,24]. This study was performed to investigate the basis of this divergent phenotype related to a single gene mutation.…”