Evaluation of carotid intima-media thickness and carotid arterial stiffness in children with adenotonsillar hypertrophy

Çiftel, Murat; Demir, Burak Furkan; Kozan, Günay; Yılmaz, Osman; Kahveci, Hasan; Kılıç, Ömer

doi:10.1007/s12519-015-0066-7

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…Our measurements are congruent with earlier reports from 5‐ to 10‐year‐old controls, 20 , 21 who demonstrated a stiffness index (beta) of 2.9 to 3.0. Arterial stiffness reflects a smaller arterial capacity to respond to pressure changes, either as a defect fetal deposition of elastin in the arterial wall, 22 or due to accelerated loss of elasticity.…”

Section: Discussionsupporting

confidence: 92%

Arterial Stiffness and Carotid Intima‐Media Thickness in Children Exposed to Smokeless Tobacco in Fetal Life

Nordenstam,

Norman,

Caidahl

et al. 2024

JAHA

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Background Arterial stiffening and increased intima‐media thickness can be seen as early as childhood and are associated with increased risk of cardiovascular events in adult life. The authors hypothesized that exposure to prenatal smokeless tobacco (Swedish snus) without additional nicotine exposure after the breastfeeding period would be associated with increased arterial stiffness and intima‐media thickening in preschool children. Methods and Results This was a longitudinal follow‐up cohort study of children aged 5 to 6 years exposed to high doses of nicotine in utero. Women exclusively using snus and unexposed controls were enrolled in early pregnancy (gestational age range, 6–12 weeks). Exposure data were collected during and after pregnancy with questionnaires from both groups. For this study, only children of women using >48 mg nicotine per day during their entire pregnancy were included in the exposure group. Outcomes were determined in 40 healthy children (21 exposed to snus in utero). Ultrasonography of the common carotid artery was used to determine carotid intima‐media thickness and calculate arterial stiffness index from the relationship between pulsatile changes in arterial diameter and arterial pressure. Children exposed to snus in fetal life had higher carotid stiffness (median 4.1 [interquartile range (IQR), 2.4–5] versus 2.9 [IQR, 2.1–3.5]; P =0.014) than tobacco‐free controls. Carotid strain (relative diameter change) was lower in children exposed to snus (mean 16% [SD, 5.7%] versus 21% [SD, 6.6%]) than in controls ( P =0.015). Carotid intima‐media thickness did not differ significantly between children exposed to snus and controls. Conclusions Exposure to snus during fetal life was associated with a stiffer carotid artery in preschool children.

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Section: Discussionsupporting

confidence: 92%

Arterial Stiffness and Carotid Intima‐Media Thickness in Children Exposed to Smokeless Tobacco in Fetal Life

Nordenstam,

Norman,

Caidahl

et al. 2024

JAHA

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“…Two pediatric studies (including a mixed child–adolescent cohort and an adolescent-only cohort) found no association between OSA and cIMT as a surrogate measure of atherosclerosis independently of obesity,328,329 but a more recent study of 40 children with adenotonsillar hypertrophy aged 5–10 years and 36 age- and BMI-matched controls found a higher cIMT in the adenotonsillar hypertrophy group 330. One study of 30 children and adolescents with primary snoring vs BMI-, age-, and sex-matched controls found a greater degree of peripheral arterial stiffness as measured by brachial–ankle PWV in those with primary snoring,329 but two subsequent studies found no association between OSA and central arterial stiffness and carotid–femoral PWV 330,331. Finally, one study of preschool-aged and school-aged children with OSA found a reduced left ventricular ejection fraction (although no clinical signs of heart failure) and that in some of the subjects, treatment of OSA improved left ventricular ejection fraction 332…”

Section: Obstructive Sleep Apnea and Cardiometabolic Riskmentioning

confidence: 95%

Role of sleep quality in the metabolic syndrome

Koren¹,

Dumin²,

Gozal³

2016

DMSO

142

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Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literature on such important issues and provide a comprehensive overview of the most salient pathophysiologic pathways underlying the links between sleep, sleep disorders, and cardiometabolic functioning.

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“…В недавнем исследовании [12] визуализационный показатель толщины комплекса интимамедиа (КИМ) у детей от 5 до 10 лет с ХТ оказался выше, чем в контрольной группе здоровых детей того же возраста, что дало возможность авторам говорить о повышенном риске развития субклинического атеросклероза в этом возрасте при анамнезе заболевания от 1 до 10 лет. Однако при этом обе группы значимо не различались по некоторым показателям СЖ.…”

Section: характеристика факторов риска у пациентов с декомпенсированн...unclassified

Tonsil problem and its cardiovascular aspects at present stage

Eremin,

Simkhes,

Evsev’eva

et al. 2023

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A comparative assessment of the characteristics of myocardial and vascular damages as well as their occurrence in patients with decompensated chronic tonsillitis (CT) sent to the hospital for planned tonsillectomy were carried out. 179 people aged 18 to 25 years were examined. Two groups were formed: group 1: patients with decompensated СT (102 people) and group 2: control – that is, persons without СТ (77 people). We used 24-hour ECG monitoring (Holter) with a set of additional diagnostic options and EchoCG to determine various characteristics of myocardial activity. The arterial wall was assessed using indicators of vascular stiffness and assessment of blood pressure balance in the vascular territories. We used hardware-diagnostic complexes DMS Advanced Technologies (Russia) and RuSkan-70P (Russia). Myocardial damage was judged by exceeding the upper limit of the permissible norm for such indicators as the number of extrasystoles per hour, the maximum rate of increase in pressure in the aorta (dP/dTmax), and the size of the heart chambers; and damage to the vascular wall was judged by similar changes for the aortic pulse wave (PWVao), aortic reverse pulse wave augmentation index (AIx ao), and ankle-brachial index (ABI). The individual profile of the main cardiovascular risk factors was also assessed. Data processing was carried out using the Statistica 10.0 software package (StatSoft Inc., USA). The results indicated the presence of a negative effect of СТ not only on the myocardium with the development of some moderate changes but also on the vascular wall. The latter violations were recorded significantly more often. Vascular disorders were characterized by increased arterial stiffness and pressure imbalance within the framework of preclinical arterio- and atherosclerosis. It is necessary to develop targeted angioprotective measures with СТ and their inclusion in the comprehensive process of managing this category of patients, including in the preoperative period. Therefore, the management of such patients should be based on the principles of effective interdisciplinary cooperation.

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Evaluation of carotid intima-media thickness and carotid arterial stiffness in children with adenotonsillar hypertrophy

Abstract: The present study revealed increased carotid intima-media thickness in children with adenotonsillar hypertrophy. The risk of subclinical atherosclerosis may be higher in children with adenotonsillar hypertrophy.

Cited by 6 publications

References 38 publications

Arterial Stiffness and Carotid Intima‐Media Thickness in Children Exposed to Smokeless Tobacco in Fetal Life

Arterial Stiffness and Carotid Intima‐Media Thickness in Children Exposed to Smokeless Tobacco in Fetal Life

Role of sleep quality in the metabolic syndrome

Tonsil problem and its cardiovascular aspects at present stage

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