Evaluation of Cardiac Glycosides in Isolated Heart Preparations Other than Papillary Muscle

Greeff, K.; Häfner, D.

doi:10.1007/978-3-642-68163-9_10

Cited by 8 publications

(3 citation statements)

References 52 publications

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“…Positive inotropic compounds, diuretics and vasodilators are the mainstay of current therapy of heart failure. Positive inotropic responses can be quantitated on isolated cardiac tissues such as the papillary muscle (Reiter 1981) and left atrium (Greeff & Hafner 1981). These tissues from rat hearts have been used to screen positive inotropic compounds (Bohm et al 1989) or to elucidate positive inotropic mechanisms (e.g.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Inotropic and Chronotropic Responses in Rat Isolated Atria and Ventricles

Brown

Sernia

Newling

et al. 1991

Clin Exp Pharma Physio

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1. The positive inotropic and chronotropic responses to adrenoceptor agonists (noradrenaline, phenylephrine), to compounds which increase cAMP by post-adrenoceptor mechanisms (forskolin, theophylline and dibutyryl cAMP) and to calcium chloride were measured in isolated rat atria and papillary muscles from both ventricles. 2. Noradrenaline produced similar maximal inotropic responses to calcium chloride in all tissues. Forskolin gave similar responses to calcium chloride in atrial but not ventricular tissues; the reverse was observed with dibutyryl cAMP. Phenylephrine and theophylline produced significantly smaller inotropic responses than calcium chloride in all tissues, especially in ventricular tissues. 3. Maximal chronotropic responses to noradrenaline, theophylline and dibutyryl cAMP were similar. Forskolin produced significantly greater responses while calcium chloride and phenylephrine produced significantly smaller responses than noradrenaline. 4. These results show that the maximal positive inotropic response of some agonists is markedly dependent on the tissue chosen. Further, chronotropic responses in right atria do not mimic inotropic responses in left atria.

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Section: Introductionmentioning

confidence: 99%

Comparison of Inotropic and Chronotropic Responses in Rat Isolated Atria and Ventricles

Brown

Sernia

Newling

et al. 1991

Clin Exp Pharma Physio

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show abstract

“…Surveys on the evaluation of cardiac glycosides have been given by Bahrmann and Greef (1981), for the use of the isolated papillary muscle by and for other isolated heart preparations by Greef and Hafner (1981). Moreover, the influence on Na + /K + -ATPase, an in vitro model specific for cardiac glycosides (Gundert-Remy and Weber 1981), is described.…”

Section: Critical Assessment Of the Methodsmentioning

confidence: 99%

“…The method is suitable for the quick determination of efficacy of digitalis-like substances and facilitates the discrimination from other positive inotropic compounds like adrenaline. Greef K, Hafner D (1981)…”

Section: Methodsmentioning

confidence: 99%