Evaluation of cardiac functions with Doppler echocardiography in children with Down syndrome and anatomically normal heart

Al‐Biltagi, Mohammed; Serag, Amany R.; Hefidah, Mohammed M.; Mabrouk, Maaly M.

doi:10.1017/s1047951112000613

Cited by 26 publications

(31 citation statements)

References 21 publications

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“…Our study agreed with the results of these reports, which indicated a significantly higher heart rate in Down syndrome subjects than in normal children (21)(22)(23). This finding is considered to be due to the autonomic cardiac dysfunction occurring at the central brain stem site as a result of a genetic disorder (24).…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 58%

“…2017; 27(1):e5735. 3 ventricular diastolic function compared with that of normal children in other reports (21,22). In other studies, these ratios were reported to be lower in their Down syndrome subjects than in their control group.…”

Section: Discussionmentioning

confidence: 60%

“…In a similar study conducted by Al-Biltagi, these rates were reported to be 1.57 and 1.04, respectively (21). Both these ratios were lower than those of normal subjects in other reports that found a similar difference (21,22). This weakened rightsided diastolic performance may be due to defective cardiac autonomic performance, cardiac hypertrophy by inhibited calcineurin signaling, or cardiac muscle fiber dysfunction (13,(26)(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 77%

“…They believed that this higher ejection fraction is due to the reduced afterload and not to the intrinsic abnormalities of the myocardium. Al-Biltagi et al reported a relatively similar ejection fraction in their Down syndrome subjects (68.1%), and it was significantly higher than that of their normal group subjects (21).…”

Section: Discussionmentioning

confidence: 80%

See 4 more Smart Citations

Evaluation of Left Ventricle Systolic and Diastolic Functions by Tissue Doppler Echocardiography in Children with Down Syndrome

et al. 2017

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 80%

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Evaluation of Left Ventricle Systolic and Diastolic Functions by Tissue Doppler Echocardiography in Children with Down Syndrome

et al. 2017

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Assessing Cognitive Improvement in People with Down Syndrome: Important Considerations for Drug-Efficacy Trials

Fernandez

Reeves

2015

Cognitive Enhancement

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Experimental research over just the past decade has raised the possibility that learning deficits connected to Down syndrome (DS) might be effectively managed by medication. In the current chapter, we touch on some of the work that paved the way for these advances and discuss the challenges associated with translating them. In particular, we highlight sources of phenotypic variability in the DS population that are likely to impact performance assessments. Throughout, suggestions are made on how to detect meaningful changes in cognitive-adaptive function in people with DS during drug treatment. The importance of within-subjects evaluation is emphasized.

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Speckle Tracking and Myocardial Tissue Imaging in Infant of Diabetic Mother with Gestational and Pregestational Diabetes

et al. 2014

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The aim of this study was to evaluate the myocardial changes in infants of diabetic mother either with gestational or pregestational diabetes and its relation to maternal diabetic control. The study included 45 infants of diabetic mother (IDMs) and 45 healthy newborn as a control group. IDMs were then categorized into 2 subgroups: twenty infants of mother with pregestational diabetes and twenty-five infants of mothers with gestational diabetes. The studied groups underwent measurement of the maternal and neonatal glycated Hb % (HbA1c), conventional echocardiography, tissue Doppler imaging (TDI) and two-dimensional speckle tracking imaging (STI). The weight, the rate of complications, and the rate of cesarean section were significantly higher in the IDMs group than in the control group. Significant positive correlation was present between the levels of HbA1c of IDMs and HbA1c of their mothers (P < 0.05). A significant deterioration of both systolic and diastolic functions measured by both conventional echocardiography and TDI was present in IDMs with both pre-gestational and gestational diabetes compared with the control group. Also, the septal/posterior wall ratio (SW/PW) was significantly higher in pregestational (1.86 ± 0.3) and gestational (2 ± 0.4) groups than in the control group (1 ± 0.06). Two-dimensional STI showed that the cardiac torsion was significantly impaired in pre-gestational (9.66 ± 2.5) and gestational (8.66 ± 3.9) groups when compared with the control group (5.4 ± 2.4) [P < 0.0001]. It also showed that the global strain was significantly impaired in pre-gestational (-10.4 ± 3.2) and gestational (-13.1 ± 4.7) groups when compared with the control group (-19 ± 2) [P < 0.0001]. However, no significant differences were present among the two patients' subgroups in echocardiographic data except for a significant decrease of E'/A' ratio and S wave at tricuspid annulus derived by TDI and impaired global strain derived by STI in infants of mothers with pre-gestational DM than those with gestational DM [P = 0.02]. SW/PW and cardiac torsion were significantly higher in infant of diabetic mother than the normal newborn and on the contrary systolic function and global strain were significantly lower in IDMs especially in infants of mother with pre-gestational diabetes. All the previous TDI findings did not show any significant correlation to neither maternal nor fetal HbA1c. Also, there was no significant correlation between cardiac torsion and the rest of TDI data neither in IDMs group nor in the control group. TDI and two-dimensional STI were efficient and sensitive tools able to early detect cardiac dysfunction in IDMs even in the absence of morphologic cardiac changes.

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Evaluation of cardiac functions with Doppler echocardiography in children with Down syndrome and anatomically normal heart

Cited by 26 publications

References 21 publications

Evaluation of Left Ventricle Systolic and Diastolic Functions by Tissue Doppler Echocardiography in Children with Down Syndrome

Evaluation of Left Ventricle Systolic and Diastolic Functions by Tissue Doppler Echocardiography in Children with Down Syndrome

Assessing Cognitive Improvement in People with Down Syndrome: Important Considerations for Drug-Efficacy Trials

Speckle Tracking and Myocardial Tissue Imaging in Infant of Diabetic Mother with Gestational and Pregestational Diabetes

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