Evaluation of Cardiac Effect in Acute Organophosphate Poisoning

Abstract

Aim The aim of this study is to investigate the cardiac effects in acute organophosphate poisonings with the emergency approach. Material and Methods Patients over the age of 15 with cholinergic toxic syndrome symptoms who applied to the Emergency Medicine Department due to organophosphate poisoning were prospectively included in the study. The type and level of organophosphate were analyzed. Creatine kinase, creatine kinase MB isoenzyme, troponin T, pseudocholinesterase were measured. Rhythm, rate, PR distance, corrected QT interval, ST-T changes, right and left bundle branch block, right and left axis deviation were evaluated in ECG. Results Forty-six patients (27 female, 19 male), were included in the study. The 6th hour creatine kinase, creatine kinase MB and Troponin T values of the patients were significantly higher than values at the time of admission. A positive and statistically significant correlation was found between the creatine kinase values at the time of admission and the pseudocholinesterase values of the patients. A positive correlation was found between creatine kinase -MB and pseudocholinesterase values at the time of admission. Similarly, a positive correlation was found between Troponin-T and pseudocholinesterase. After taking Diazinon, Chlorpyrifos and Cypermethrin, sinus tachycardia was observed at the time of admission. After carbofuran intake, the ECG rhythm at admission was normal, and sinus tachycardia was observed at the 6th hour. It was determined that the QT interval was long at the time of admission after taking Chlorpyrifos. After diazinon and cypermethrin intake, the QT interval was evaluated as long at the 6th hour. Left bundle branch block was observed after cypermethrin intake. Conclusion Organophosphate compounds are one of the important causes of poisoning. The results of this study, which examines cardiac enzymes and ECG changes after organophosphate poisoning, will provide important contributions to the literature.