Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection

Silva, Raúl Alejandro; Talio, María Carolina; Luconi, Marta Olga; Fernández, Liliana Patricia

doi:10.1016/j.jpba.2012.06.031

Cited by 22 publications

(15 citation statements)

References 21 publications

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“…Therefore, a wide range of new technologies for chiral separation has been developed, among them carbon nanotechnology. Silva et al [43] have recently used a microcolumn packed with SWCNT as chiral selector for separation of carvedilol enantiomers, a β -blocker, with fluorescent detection. Yu et al [12] have developed a chiral stationary phase of MWCNT cross-linked with hydroxypropyl- β -cyclodextrin for enantioseparation of racemic clenbuterol, a bronchodilator, with-high-resolution factor.…”

Section: Applications Of Carbon Nanotubes In Pharmacy and Medicinementioning

confidence: 99%

Carbon Nanotubes: Applications in Pharmacy and Medicine

Pham-Huy

Dramou

et al. 2013

BioMed Research International

398

230

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Carbon nanotubes (CNTs) are allotropes of carbon, made of graphite and constructed in cylindrical tubes with nanometer in diameter and several millimeters in length. Their impressive structural, mechanical, and electronic properties are due to their small size and mass, their strong mechanical potency, and their high electrical and thermal conductivity. CNTs have been successfully applied in pharmacy and medicine due to their high surface area that is capable of adsorbing or conjugating with a wide variety of therapeutic and diagnostic agents (drugs, genes, vaccines, antibodies, biosensors, etc.). They have been first proven to be an excellent vehicle for drug delivery directly into cells without metabolism by the body. Then other applications of CNTs have been extensively performed not only for drug and gene therapies but also for tissue regeneration, biosensor diagnosis, enantiomer separation of chiral drugs, extraction and analysis of drugs and pollutants. Moreover, CNTs have been recently revealed as a promising antioxidant. This minireview focuses the applications of CNTs in all fields of pharmacy and medicine from therapeutics to analysis and diagnosis as cited above. It also examines the pharmacokinetics, metabolism and toxicity of different forms of CNTs and discusses the perspectives, the advantages and the obstacles of this promising bionanotechnology in the future.

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Section: Applications Of Carbon Nanotubes In Pharmacy and Medicinementioning

confidence: 99%

Carbon Nanotubes: Applications in Pharmacy and Medicine

Pham-Huy

Dramou

et al. 2013

BioMed Research International

398

230

View full text Add to dashboard Cite

show abstract

“…The chirality is believed to arise from the spiral alignment (either left- or right handed) of the hexagonal rings along the nanotube axis [46, 47]. Thus far, only limited attempts have been reported in recent years involving capillary electrophoretic [48, 49] and flow injection analysis systems [50]. …”

Section: Resultsmentioning

confidence: 99%

Facile preparation of octadecyl monoliths with incorporated carbon nanotubes and neutral monoliths with coated carbon nanotubes stationary phases for HPLC of small and large molecules by hydrophobic and π–π interactions

Mayadunne

Rassi

2014

Talanta

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Two approaches for incorporating carbon nanotubes into monolithic columns for HPLC are described in this report. They pertain to the investigation of carbon nanotubes either (i) as entities to modulate solute retention on monolithic columns bearing well defined retentive ligands or (ii) as entities that constitute the stationary phase responsible for solute retention and separation. Approach (i) involved the incorporation of carbon nanotubes into octadecyl monolithic columns while approach (ii) concerns the preparation and evaluation of an ideal monolithic support and coating it with carbon nanotubes to yield a real “carbon nanotube stationary phase” for the HPLC separation of a wide range of solutes. First, an octadecyl monolithic column based on the in situ polymerization of octadecyl acrylate and trimethylolpropane trimethacrylate was optimized for use in HPLC separations of small and large solutes (e.g., proteins). To further modulate the retention and separation of proteins, small amounts of carbon nanotubes were incorporated into the octadecyl monolith column. In approach (ii), an inert, relatively polar monolith based on the in situ polymerization of glyceryl monomethacrylate (GMM) and ethylene glycol dimethacrylate (EDMA) proved to be the most suitable support for the preparation of “carbon nanotube stationary phase”. This carbon nanotube “coated” monolith proved useful in the HPLC separation of a wide range of small solutes including enantiomers. In approach (ii), a more homogeneous incorporation of carbon nanotubes into the diol monolithic columns (i.e., GMM/EDMA) was achieved when hydroxyl functionalized carbon nanotubes were incorporated into the GMM/EDMA monolithic support. In addition, high power sonication for a short time enhanced further the homogeneity of the monolith incorporated with nanotubes. In all cases, nonpolar and π interactions were responsible for solute retention on the monolith incorporated carbon nanotubes.

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“…In this experimental condition, the obtained EF was 20, providing evidence about the improvement in the sensitivity of the proposed methodology for the MWCNTs. Nanomaterial activation was realised by oxidation (Osorio et al 2008;Tang & Xu 2011;Silva et al 2012) using different chemical substances. The chemical functionalisation by mean HNO 3 (2 mequiv.…”

Section: Resultsmentioning

confidence: 99%

Quantification of caffeine in dietary supplements and energy drinks by solid-surface fluorescence using a pre-concentration step on multi-walled carbon nanotubes and Rhodamine B

Talio

Acosta

Alesso

et al. 2014

Food Additives & Contaminants: Part A

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A new method for the determination of caffeine, a non-fluorescent analyte, based on the enhancement of the fluorescence of Rhodamine B dye on a membrane filter modified with multi-walled carbon nanotubes is proposed. The method comprises pre-concentration of caffeine on a solid support by chemofiltration in buffered solution onto multi-walled carbon nanotubes previously oxidised and dispersed in cationic surfactant admicelles. The effect of experimental parameters, including the nature of the buffer and pH, the nature of the solid support, filtration flow rate, dye and carbon nanotube concentration, and the nature of the surfactant and concentration were investigated by means univariation assays. Under optimum experimental conditions, the pre-concentration system gave detection and quantification limits of 0.3 and 1.1 µg l(-1), respectively. A wide linear range was achieved varying from concentrations of 1.1 to 9.7 × 103 µg l(-1) (r(2) = 0.999). Satisfactory recovery values were obtained using the method of standard addition, confirming the feasibility of this method for caffeine determination in energising dietary supplements and energy drinks.

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Evaluation of carbon nanotubes as chiral selectors for continuous-flow enantiomeric separation of carvedilol with fluorescent detection

Cited by 22 publications

References 21 publications

Carbon Nanotubes: Applications in Pharmacy and Medicine

Carbon Nanotubes: Applications in Pharmacy and Medicine

Facile preparation of octadecyl monoliths with incorporated carbon nanotubes and neutral monoliths with coated carbon nanotubes stationary phases for HPLC of small and large molecules by hydrophobic and π–π interactions

Quantification of caffeine in dietary supplements and energy drinks by solid-surface fluorescence using a pre-concentration step on multi-walled carbon nanotubes and Rhodamine B

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