Evaluation of calciotropic hormones in cats with odontoclastic resorptive lesions

Abstract

Results did not indicate associations between iPTH, PTHrP, or fT4 and development of ORLs. In affected cats, the importance of high serum 25-OHD and low urine specific gravity has not been determined.

Dental Health and Diet

“…Although limited data are available, a positive association has also been reported between resorptive lesions and feeding noncommercial (homemade) diets, cat treats, table foods, and diets containing low amounts of calcium or high amounts of vitamin D. [80][81][82] The increased use of acid sprays as a coating on dry cat foods and of urine-acidifying diets for the prevention of struvite urolithiasis in cats led to speculation that some commercial cat foods may reduce the oral pH and promote an environment that is favorable for tooth demineralization. A study that examined risk factors for the development of odontoclastic lesions in 145 adult cats reported that the two most important factors associated with resorptive lesions were increasing age and feeding a cat food that contained low levels of magnesium.…”

“…Neither the type of diet fed (soft versus hard) nor the number of feedings provided per day was associated with the development of dental lesions. 82,87 Studies that are designed to examine the potential relationship between dietary levels of vitamin D and the development of FORL are needed. To examine this theory, a study was conducted to determine whether the pH of a cat food and that of a cat's tooth surfaces after eating are correlated.…”

Tooth Resorption and Vitamin D3 Status in Cats Fed Premium Dry Diets

“…It was suggested that a higher prevalence of TR in cats was associated with a higher vitamin D 3 (25-OH-D) serum concentration (although within the normal reference range). 5 However, another study found no statistically significant difference in 25-OH-D concentrations between cats with TR and those without TR. 6 The purpose of this study was to measure the serum 25-OH-D concentrations of a colony of domestic cats, and to evaluate any possible correlation with the prevalence of TR.…”

<b>Estudo retrospectivo das afecções orais em 754 felinos domésticos (<i>Felis catus</i>) atendidos no Laboratório de Odontologia Comparada da Universidade de São Paulo</b>

“…Tem como sinal clínico perda progressiva do tecido dentário, causada pela reabsorção de sua parte mineral (REITER et al, 2005), existindo, com frequência, casos com reabsorção total de uma das raízes, muitas vezes, visível somente ao exame radiográfico (WIGGS; LOBPRISE, 1997;GIOSO, 2007;VIEGAS;SANTOS, 2014).…”

“…Em geral, ocorre na porção cervical do dente, visualmente semelhante à cárie, embora de etiologia distinta. Há lesões que se iniciam no interior do dente, junto à polpa e progridem para o exterior, destruindo completamente o elemento dentário (GIOSO, 2007;LOBPRISE, 2010).Tem como sinal clínico perda progressiva do tecido dentário, causada pela reabsorção de sua parte mineral (REITER et al, 2005), existindo, com frequência, casos com reabsorção total de uma das raízes, muitas vezes, visível somente ao exame radiográfico (WIGGS; LOBPRISE, 1997;GIOSO, 2007;VIEGAS;SANTOS, 2014).A maior parte dos gatos não apresenta sinais clínicos evidentes; os proprietários podem reportar dificuldade do paciente para comer ração dura, recusa em beber água fria e movimentos repetitivos da mandíbula (reflexo de abertura da mandíbula) (LOBPRISE, 2010).Apesar de existirem muitos fatores associados à LRDF, a sua etiopatogenia permanece indeterminada (WIGGS; LOBPRISE, 1997;DUPONT;DEBOWES, 2002;GIOSO, 2007;LOBPRISE, 2010;MESTRINHO et al, 2013). Alguns autores levantaram hipóteses: estresse da mastigação, inflamação, agentes infecciosos (Actinomyces sp, FIV, FeLV, Calicivírus), desordens do sistema imune, desordem no sistema regulador de cálcio, superfície ácida da ração de gatos, vômitos e alterações de pH.…”