Evaluation of C-Reactive Protein in Patients with Chronic Obstructive Pulmonary Disease

Simonovska, Ljiljana; Ahmeti, Irfan; Mitreski, Vladimir

doi:10.3889/oamjms.2015.061

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…The level of CRP showed significant correlation with the severity of clinical presentation according to GOLD classification. The higher the CRP concentration, the higher was the disease severity determined according to GOLD classification (p<0.001) [24], Simonovska also reported significant statistically difference between mean values of CRP and GOLD categories [25]. Similar result also reported by Nillawar in group of patients from India and the result was statistically difference between mean value of CRP and GOLD IV when compared with GOLD II or GOLD III with P = 0.0089 and P = 0.03 respectively [26].…”

Section: Discussionsupporting

confidence: 58%

Relationship between Chronic Obstructive Pulmonary Disease (COPD) and C- Reactive Protein (Crp)

Al Busaidi

2018

Madridge J Intern Emerg Med

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Chronic obstructive pulmonary disease (COPD) is a major worldwide health problem which leads to expiratory air-flow limitation which is often slowly progressive over the years. C-Reactive Protein (CRP) usually elevated in patients with COPD and used as a marker for inflammation. Objectives:The objective of the study to see whether CRP correlated with the severity of COPD in the form of lung function test.Method: This is a retrospective study, from patients with COPD followed up in a tertiary hospital between Jun 2011 to Dec 1016 who have both CRP measurement and spirometry in same period.Result: Total number of patient were 159 (84.2% male), mean age was 66 years, most of the patients presented with dyspnea (>73%) followed by cough (>58%) and about quarter of the patient with wheezing. Based on Global Initiative for Obstructive Lung disease(GOLD) classification; most of the patient belong to GOLD II (51.5%), then GOLD III (27%), then GOLD I (13.3) and only 8.2 belong to GOLD IV. Majority of our patients (73%) had raised CRP level (> 5 mg/L), our study showed no significant difference between CRP and GOLD stages but there is a linear negative correlation between FEV1% and CRP level and we found each unit increase of CRP level, there will be decrease of FEV1 by 0.001. This finding is novel as it hasn't been documented elsewhere. Conclusion:our study shows that there is a linear negative correlation between FEV1% and CRP level in stable COPD patients.

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Section: Discussionsupporting

confidence: 58%

Relationship between Chronic Obstructive Pulmonary Disease (COPD) and C- Reactive Protein (Crp)

Al Busaidi

2018

Madridge J Intern Emerg Med

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“…No statistically significant correlations were found between the level of CRP, the leukocyte count, and comorbidities. Simonovska et al [17] found statistically significant differences in the mean value of CRP in patients with different level of bronchial obstruction. For many years, an easily measurable and noninvasive parameter which might reflect systemic inflammation has been researched.…”

Section: Discussionmentioning

confidence: 97%

Stabil kronik obstrüktif akciğer hastalığında ortalama trombosit hacmi ve trombosit dağılım genişliğinin hastalık şiddeti ile ilişkisinin değerlendirilmesi

Uysal

2018

Archives of Clinical and Experimental Medicine

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Aim: This study was conducted to evaluate the relationship between disease severity, mean platelet volume and platelet distribution width in stable chronic obstructive pulmonary disease. Methods: The study included 120 consecutive patients with stable chronic obstructive pulmonary disease and 30 consecutive age-matched healthy subjects (control group). Patients were classified as A (mild), B (mild to moderate), C (moderate to severe) and D (severe) defined by the GOLD committee and grouped as A/B (n= 60) and C/D (n=60). Results: Platelet levels were not different among the groups. Mean platelet volume was lower in all patients than control group (p=0.001). Level of platelet distribution width was higher in all patients than control group (p=0.018). Mean platelet volume in C/D groups were significantly lower than A/B group (p=0.011) and control group (p=0.001). Mean platelet volume in A/B group were also significantly lower than control group (p=0.001). Erythrocyte sedimentation rates were higher in A/B and C/D groups than control group (p=0.007 and p=0.001, respectively). C-reactive protein levels in control group were significantly lower than C/D group (p=0.001). No statistically significant correlations were observed between mean platelet volume and forced expiratory volume in one second and forced expiratory volume in one second/forced vital capacity or between mean platelet volume and other inflammatory parameters in A/B or C/D groups. Significant positive correlations were found between erythrocyte sedimentation rate and C-reactive protein (r=0.375; p=0.003), and between mean platelet volume and platelet large cell ratio (r=0.749; p=0.001) in C and D groups. Conclusion: It was concluded that mean platelet volume could be used as a negative acute phase reactant in evaluation of disease severity of chronic obstructive pulmonary disease as C-reactive protein.

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“…They are likewise the reason for successive hospitalization, expanded medical services and economic burden and mortality related to the disease (8). Although viral and additionally bacterial diseases and air contamination are involved in the pathogenesis of acute exacerbation of COPD, the explanation for 33 percent of the acute exacerbation of the disease remain unknown (9). Chronic irritation is often considered to be the causative factor in the causation of COPD; there also has been demonstrated proof of fundamental oxidative stress, circulating inflammatory cells and raised degrees of other biomarkers like C-reactive protein.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Acute Exacerbation of COPD Among Non-smokers in Tertiary Care Hospital of Bannu KPK-Pakistan

Khan¹,

Khan²,

Khan³

et al. 2022

jwmdc

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ABSTRACT Background: chronic obstructive pulmonary disease is common disease with frequent exacerbations especially in winter season. Frequency of COPD exacerbation is more among smokers as compared to general public. Current study was done to evaluate the frequency of acute exacerbation of COPD among non-smokers. Methods: this cross-sectional descriptive study was performed at Department of medicine, DHQ hospital Bannu over a period of one year from 22-2-2021 to 22-2-2022. About 193 COPD patients aged 35 to 80 years were included in this study. Patients with other lung diseases like TB, pneumoconiosis, silicosis, pleural effusion, interstitial lung diseases, bronchiectasis and history of pneumonectomy were excluded from the study. Complete history including history of smoking, socio economic status and co morbidities was taken. Complete general physical and systemic examination including chest and cardiovascular examination was performed. Spirometry was done and findings were recorded. Results: Among 193 patients, 55.4% and 44.6% were male and female respectively. Mean age was 58.89 years ± 10.82 SD. Among these 193 patients, 88.1% were uneducated, 6.2%, 29.6%, 32.6% and 31.6% were presented with mild, moderate, severe and very severe COPD respectively. Among them, 22.3% patients were hypertensive, 14% were diabetic and 1.6% were having thyroid disease. Frequency of non-smoker (50.3%) was stratified on the basis of gender (p=0.01), age (p= 0.16), duration of COPD (p=0.001), educational status (p=0.03), spirometry findings (p=0.73), hypertension (p=0.41), diabetes mellitus (p=0.85) and thyroid diseases (p=0.55). Conclusion: Approximately half of patients with acute exacerbation of chronic obstructive pulmonary disease were non-smokers. Of these, females were more likely to be non-smokers than males.

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Evaluation of C-Reactive Protein in Patients with Chronic Obstructive Pulmonary Disease

Cited by 4 publications

References 15 publications

Relationship between Chronic Obstructive Pulmonary Disease (COPD) and C- Reactive Protein (Crp)

Relationship between Chronic Obstructive Pulmonary Disease (COPD) and C- Reactive Protein (Crp)

Stabil kronik obstrüktif akciğer hastalığında ortalama trombosit hacmi ve trombosit dağılım genişliğinin hastalık şiddeti ile ilişkisinin değerlendirilmesi

Frequency of Acute Exacerbation of COPD Among Non-smokers in Tertiary Care Hospital of Bannu KPK-Pakistan

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