Evaluation of c-KIT protein expression in canine mammary tumors

Salvador, R; Raposo, Talita Mm; Fonseca‐Alves, Carlos Eduardo; Terra, Erika Maria; Varallo, Giovanna Rossi; Laufer-Amorim, Renée

doi:10.1186/1753-6561-7-s2-p63

Cited by 2 publications

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“…In dogs with mammary tumors, c-KIT exhibits a controversial role in tumorigenesis [15,16,17]. In general, c-KIT is expressed in normal mammary glands.…”

Section: Introductionmentioning

confidence: 99%

“…In general, c-KIT is expressed in normal mammary glands. During cancer progression, tumor cells lack c-KIT expression [15,16,17]. Regarding PDGFR, one previous study evaluated gene expression in CMT [17], and no previous study demonstrated PDGFR expression in CMT.…”

Section: Introductionmentioning

confidence: 99%

“…In humans and dogs, the development of metastasis is the major cause of cancer-related deaths [6,15]. The PDGFR and PDGF signaling pathway is responsible for intratumoral lymphogenesis, promoting nodal metastasis [21], and the VEGF/VEGFR pathway induces neovasculogenesis [22].…”

Section: Introductionmentioning

confidence: 99%

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Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Negative Model of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis

Anjos

Vital

Lainetti

et al. 2019

Veterinary Sciences

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Canine mammary tumors (CMT) represent the most common cancer in noncastrated female dogs. Interestingly, triple-negative tumors are the most common molecular subtype in female dogs. In this study, we proposed to evaluate the expression of vascular endothelial growth factor receptor 2 (VEGFR-2), Platelet-derived growth factor receptor (PDGFR), and microvascular density (MVD) in a group of metastatic and nonmetastatic triple-negative CMT and compare the expression based on clinical parameters. Twenty-six female dogs with triple-negative mammary tumors were divided into three groups: nonmetastatic tumors (NMT) (n = 11), tumors with lymph node metastasis (LNM) (n = 10), and tumors with lung metastasis (LM) (n = 5). We observed increased VEGFR-2 expression in LNM compared with NMT and a positive correlation between tumor grade and VEGFR-2 expression. A positive correlation was noted between VEGFR-2 and PDGFR expression. Regarding microvascular density (MVD), we identified a higher number of vessels in primary tumors with lymph node metastasis and lung metastasis compared with tumors with no metastasis. The primary tumors with lung metastasis exhibited an increased MVD compared with carcinoma with lymph node metastasis. Overall, our results suggest a deregulation of VEGFR-2 and PDGFR and high MVD in metastatic tumors, indicating a role for angiogenesis in tumor progression.

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“…In dogs with mammary tumors, c-KIT exhibits a controversial role in tumorigenesis [15,16,17]. In general, c-KIT is expressed in normal mammary glands.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Negative Model of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis

Anjos

Vital

Lainetti

et al. 2019

Veterinary Sciences

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show abstract

Section: Introductionmentioning

confidence: 99%

Deregulation of VEGFR-2 and PGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis

Anjos¹,

Vital²,

Lainetti³

et al. 2018

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Canine mammary tumors (CMT) are the most common cancer in noncastrated female dogs. Interestingly, triple-negative tumors are the most common molecular subtype in female dogs. In this study, we proposed to evaluate the expression of VEGFR-2, PDGFR and microvascular density (MVD) in a group of metastatic and nonmetastatic triple-negative CMT and compare the expression based on clinical parameters. Twenty-six female dogs with triplenegative mammary tumors were divided into three groups: nonmetastatic tumors (NMT) (N=11), tumors with lymph node metastasis (LNM) (N=10) and tumors with lung metastasis (LM) (N=5). We observed increased VEGFR-2 expression in LNM compared with NMT and a positive correlation between tumor grade and VEGFR-2 expression. A positive correlation was noted between VEGFR-2 and PDGFR expression. Regarding microvascular density (MVD), we identified a higher number of vessels in primary tumors with lymph node metastasis and lung metastasis compared with tumors with no metastasis. The primary tumors with lung metastasis exhibited an increased MVD compared with carcinoma with lymph node metastasis. Overall, our results suggest a deregulation of VEGFR-2 and PDGFR and high MVD in metastatic tumors, indicating a role for angiogenesis in tumor progression. Key-words: angiogenesis. metastasis. mammary neoplasm. 1. Misdorp, W. Tumors of the mammary gland. In Tumors in Domestic Animals, 4th ed.; Meuten, D.J., Eds.; Iowa State Press: Ames, IA, USA, 2002, pp. 575-606. 2. Sorenmo, K.U.; Worley, D.R.; Goldschmidt, M.H. Tumors of the Mammary Gland. In Withrow & MacEwen's Small Animal Clinical Oncology, 5th ed.; Withrow S.J., Vail D.M., Page R.L., Eds.; Elsevier: St Louis, MO, USA, 2013, pp. 538-556. 3. DE NARDI, A.B.; RODASKI, S.; SOUSA, R.S.; COSTA, T.A.; MACEDO, T.R.; RODIGHERI, S.M.; RIOS, A.; PIEKARZ, C.H. Prevalência de neoplasias e modalidades de tratamentos em cães, atendidos no hospital veterinário da Universidade Federal do Paraná. Arch Vet Sci. 2002, 7, 15-26; http://dx.doi.org/10.5380/avs.v7i2.3977 4. Santos, I.F.C.; Cardoso, J.M.M.; Oliveira, K.C.; Laisse, C. J. M.; Bessa, S.A.T. Prevalência de neoplasias diagnosticadas em cães no Hospital Veterinário da Universidade Eduardo Mondlane, Moçambique. Arq Bras Med Vet Zootec. 2013, 65, 773-782; http://dx.doi.org/10.1590/S0102-09352013000300025 5. Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, R.L.; Torre, L.A.; Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018, 68, 394-424; https://doi.org/10.3322/caac.21492 PTEN and VEGF in canine mammary gland tumours. Vet Res Commun. 2008, 32, 463-72; https://doi.org/10.1007/s11259-008-9049-7 12. Santos, A.; Lopes, C.; Gärtner, F.; Matos, A.J. VEGFR-2 expression in malignant tumours of the canine mammary gland: a prospective survival study. Vet Comp Oncol. 2016, 14, 83-92; https://doi.org/10.1111/vco.12107 13. Cristofanilli, M.; Morandi, P.; Krishnamurthy, S.; Reuben, J.M.; Lee, B.N.; Francis, D.; Booser, D.J.; Gree...

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Evaluation of c-KIT protein expression in canine mammary tumors

Cited by 2 publications

References 0 publications

Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Negative Model of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis

Deregulation of VEGFR-2 and PDGFR Expression and Microvascular Density in a Triple-Negative Model of Canine Malignant Mammary Tumors with Lymph Node or Lung Metastasis

Deregulation of VEGFR-2 and PGFR expression and microvascular density in a triple-negative model of canine malignant mammary tumors with lymph node or lung metastasis

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