Evaluation of breast lesions by contrast enhanced ultrasound: Qualitative and quantitative analysis

Wan, Caifeng; Du, Jing; Fang, Hua; Li, Fenghua; Wang, Lin

doi:10.1016/j.ejrad.2011.03.094

Cited by 84 publications

(93 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other words, quantitative imaging techniques turn subtle invisible image information into a numeric score and by those means compare it with other digital images. Several quantitative imaging methods have been proposed, which have demonstrated to be useful for clinical purposes in breast and liver disease [21,22]. In a pioneering study, Palacio et al [9] described a new computer-based quantitative analysis model for fetal lung maturity diagnosis ("Quantitative Ultrasound Fetal Lung Maturity Analysis," quantusFLM ® ; Transmural Biotech, SL, Barcelona, Spain).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Fetal Lung Maturity by Quantitative Analysis (quantusFLM) in Women with Gestational Diabetes Mellitus

Sánchez

Mateo

et al. 2018

Fetal Diagn Ther

View full text Add to dashboard Cite

Objectives: The aim of the present study was to evaluate fetal lung maturity using the noninvasive method of quantitative ultrasound analysis of fetal lung texture (quantusFLM) in women with gestational diabetes mellitus (GDM). Methods: A total of 96 women at 36–38 weeks of gestation were enrolled. They were classified as follows: 33 GDM cases treated with diet, 30 GDM cases treated with diet plus insulin, and 33 normoglycemic women (control group). A quantitative analysis of lung texture was performed. Results: There were significant differences in the lung maturity results among groups (p = 0.004). These differences were established between the insulin-treated group of patients and both the control (p = 0.006) and diet-only (p = 0.003) groups. While none of the women in the control group or in the diet group had a high risk of immaturity, 16.7% of those treated with insulin (5/30) did (p = 0.003). There was no statistically significant correlation between HbA1c and the result of the test. Conclusions: Quantitative ultrasound study of fetal lung texture suggests that a significant percentage of pregnant women with GDM treated with insulin had fetal lung immaturity in the late preterm to early term.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Fetal Lung Maturity by Quantitative Analysis (quantusFLM) in Women with Gestational Diabetes Mellitus

Sánchez

Mateo

et al. 2018

Fetal Diagn Ther

View full text Add to dashboard Cite

show abstract

“…According to the intensity of enhancement using CEUS, contrast-enhanced images were classified into four categories: (1) no enhancement; (2) high-enhancement, in which the lesions were more highly enhanced than that of normal tissue; (3) low-enhancement, in which the lesions were less enhanced than that of normal tissue; and (4) equal-enhancement, in which lesions and normal tissues were equally enhanced [14, 16, 17]. …”

Section: Methodsmentioning

confidence: 99%

CEUS Helps to Rerate Small Breast Tumors of BI-RADS Category 3 and Category 4

Zhang

Cai

Chen

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

Purpose. The primary aim of this study was to explore if classification, whether using the BI-RADS categories based on CEUS or conventional ultrasound, was conducive to the identification of benign and malignant category 3 or 4 small breast lesions. Material and Methods. We evaluated 30 malignant and 77 benign small breast lesions using CEUS. The range of enhancement, type of enhancement strength, intensity of enhancement, and enhancement patterns were independent factors included to assess the BI-RADS categories. Results. Of the nonenhanced breast lesions, 97.8% (44/45) were malignant, while, of the hyperplasic nodules, 96.8% (30/31) showed no enhancement in our study. Category changes of the lesions were made according to the features determined using CEUS. The results showed that these features could improve diagnostic sensitivity (from 70.0 to 80.0, 80.0, 90.0, and 90.0%), reduce the negative likelihood ratio (from 0.33 to 0.22, 0.25, 0.11, and 0.12), and improve the NPV (from 88.8 to 92.2, 91.2, 96.2, and 95.5%). However, this was not conducive to improve diagnostic specificity or the PPV. Conclusion. The vast majority of nonenhanced small breast lesions were malignant and most of the hyperplasic nodules showed no contrast enhancement. As a reference, CEUS was helpful in identifying BI-RADS category 3 or 4 small breast lesions.

show abstract

“…[10][11][12] In this study, the peak signal intensity was significant only for the 15-mm ROI. The initial slope was significant in only 1 previous report, 12 but our results suggested that the initial slope was the most significant parameter. SonoVue (sulfur hexafluoride microbubbles; Bracco SpA, Milan, Italy)…”

Section: Nakata Et Al-quantitative Analysis Of Contrast-enhanced Breamentioning

confidence: 97%

“…However, the methods of ROI selection varied between studies, and previous reports have not discussed appropriate ROI selection. [10][11][12][13][14] This study was performed to investigate whether there are significant differences in kinetic parameters between benign and malignant breast lesions using different ROIs based on raw data from the same contrast-enhanced breast sonographic examinations. To our knowledge, this study is the first quantitative analysis of breast contrast-enhanced sonography using the perflubutane-based contrast agent Sonazoid, and the results were compared with previous quantitative studies using another second-generation contrast agent (SonoVue).…”

mentioning

confidence: 99%

Optimization of Region of Interest Drawing for Quantitative Analysis

Nakata

Ohta

Nishioka

et al. 2015

J of Ultrasound Medicine

View full text Add to dashboard Cite

reast cancer is the most common type of cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012, and is the second most common type of cancer overall. It represents about 12% of all new cancer cases and 25% of all cancers in women. 1 Sonography is an important modality that is frequently used in all aspects of breast imaging, including breast cancer screening, evaluation of palpable abnormalities, further characterization of lesions detected mammographically, and determining the method of percutaneous biopsy. 2 Advances in ultrasound technology include harmonic imaging, compound imaging, power Doppler imaging, faster frame rates, and higher-resolution transducers. Recently, elastography and three-dimensional sonography have also been used to evaluate breast lesions. 3 Norio Nakata, MD, Tomoyuki Ohta, MD, Makiko Nishioka, MD, Hiroshi Takeyama, MD, Yasuo Toriumi, MD, Kumiko Kato, MD, Hiroko Nogi, MD, Makiko Kamio, MD, Kunihiko Fukuda, MD Received October 16, 2014, ORIGINAL RESEARCHObjectives-This study was performed to evaluate the diagnostic utility of quantitative analysis of benign and malignant breast lesions using contrast-enhanced sonography.Methods-Contrast-enhanced sonography using the perflubutane-based contrast agent Sonazoid (Daiichi Sankyo, Tokyo, Japan) was performed in 94 pathologically proven palpable breast mass lesions, which could be depicted with B-mode sonography.Quantitative analyses using the time-intensity curve on contrast-enhanced sonography were performed in 5 region of interest (ROI) types (manually traced ROI and circular ROIs of 5, 10, 15, and 20 mm in diameter). The peak signal intensity, initial slope, time to peak, positive enhancement integral, and wash-out ratio were investigated in each ROI.Results-There were significant differences between benign and malignant lesions in the time to peak (P < .05), initial slope (P < .001), and positive enhancement integral (P < .05) for the manual ROI. Significant differences were found between benign and malignant lesions in the time to peak (P < .05) for the 5-mm ROI; the time to peak (P < .05) and initial slope (P < .05) for the 10-mm ROI; absolute values of the peak signal intensity (P < .05), time to peak (P < .01), and initial slope (P < .005) for the 15-mm ROI; and the time to peak (P < .05) and initial slope (P < .05) for the 20-mm ROI. There were no statistically significant differences in any wash-out ratio values for the 5 ROI types.Conclusions-Kinetic analysis using contrast-enhanced sonography is useful for differentiation between benign and malignant breast lesions.

show abstract

Evaluation of breast lesions by contrast enhanced ultrasound: Qualitative and quantitative analysis

Cited by 84 publications

References 15 publications

Evaluation of Fetal Lung Maturity by Quantitative Analysis (quantusFLM) in Women with Gestational Diabetes Mellitus

Evaluation of Fetal Lung Maturity by Quantitative Analysis (quantusFLM) in Women with Gestational Diabetes Mellitus

CEUS Helps to Rerate Small Breast Tumors of BI-RADS Category 3 and Category 4

Optimization of Region of Interest Drawing for Quantitative Analysis

Contact Info

Product

Resources

About