Evaluation of Brain Activity Using Near-infrared Spectroscopy in Inflammatory Bowel Disease Patients

Abstract

Depression is implicated as a risk factor for the recurrence of inflammatory bowel disease (IBD). Near-infrared spectroscopy (NIRS) and brain-derived neurotrophic factor (BDNF) are useful tools for evaluation of brain activity and a depressive state, respectively. The aim of this study was to clarify the association between brain activity or depressive symptoms and IBD using NIRS and BDNF. This study included 36 ulcerative colitis (UC) patients, 32 Crohn’s disease (CD) patients, and 17 healthy controls (HC). Center for Epidemiologic Studies Depression Scale (CES-D) scores were determined, NIRS was performed, and serum BDNF levels were measured in all subjects. NIRS showed that the mean oxygenated hemoglobin concentration was significantly lower in the frontal lobe in the UC group than in the HC group (HC 167 ± 106 vs. UC 83.1 ± 85.3, p < 0.05). No significant difference was seen between the HC and CD groups. There were also no significant differences in CED-D scores and BDNF levels among the groups. Changes in the NIRS values of the UC group may indicate decreased brain activity and a fundamental difference between UC and CD, which are often lumped together as two types of IBD.

Application of functional near-infrared spectroscopy in the healthcare industry: A review

“…135 In°ammatory bowel disease is linked with depression, and the patients with the disease also showed reduced cognitive activation in the PFC as observed via various studies on depressive disease. 136 BD patients showed lower activations in the right ventrolateral and dorsolateral PFCs and the bilateral PFC when compared to healthy persons. 137 The changes in HbO activation in MDD patients in the right inferior frontal gyrus and bilateral middle frontal gyri were associated with the extent of the disease and can be observed to distinguish di®erent impairments.…”

Near‐Infrared Spectroscopy Reveals Brain Hypoxia and Cerebrovascular Dysregulation in Primary Biliary Cholangitis

“…Using NIRS, reduced task‐induced O 2 Hb and HHb responses have been observed in several disorders, including depression and mild cognitive impairment . Of particular interest, using NIRS, one group reported decreased frontal lobe oxygenation during a verbal fluency task in patients with ulcerative colitis as well as in patients with nonalcoholic fatty liver disease but not in patients with Crohn's disease . The authors attributed these findings to altered brain activity, although it is difficult to delineate altered brain activity from altered neurovascular coupling in patients with potential cerebrovascular dysfunction …”

“…(14) Of particular interest, using NIRS, one group reported decreased frontal lobe oxygenation during a verbal fluency task in patients with ulcerative colitis as well as in patients with nonalcoholic fatty liver disease but not in patients with Crohn's disease. (31,32) The authors attributed these findings to altered brain activity, although it is difficult to delineate altered brain activity from altered neurovascular coupling in patients with potential cerebrovascular dysfunction. (8) To gain a greater understanding of how chronic immune-mediated liver inflammation impacts the brain of patients with PBC, we applied a time-frequency (coherence) analysis in conjunction with quantitative measures of hemoglobin concentration and oxygen saturation.…”

Optical biopsy methods and their prospects of application for intraoperative analysis of tissue metabolism and blood microcirculation in minimally invasive surgery

“…Этот метод широко применяется в химической и фармацевтической промышленности для исследования свойств органических и неорганических веществ, их содержания в различных объектах. В медицине данный вид спектроскопии используется для оценки оксигенации крови и лежит в основе многочисленных исследований мозговой активности в норме и патологии, при совершении каких-либо действий или эмоциональных нагрузках [25,39]. Кроме того, исследуется применение спектроскопии в ближней инфракрасной области при лапароскопических хирургических вмешательствах на органах брюшной полости [42,48].…”

“…Наряду с рассмотренной выше технологией, для визуализации кровотока в тканях почти 40 лет назад был продемонстрирован метод контрастной лазерной спекл-визуализации для неинвазивной оценки состояния микрососудистого русла в тканях сетчатки глаза [24]. В настоящее время этот метод нашел применение в хирургии для построения количественных карт кровотока [25], но пока использовать данный метод интраоперационно представляется возможным только при проведении открытых хирургических вмешательств, где сосудистая сеть более легкодоступна с поверхности [23].…”